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VMPM > Rabies > Flashcards

Rabies Flashcards

1
Q

Virion

A

Helical symmetry
Enveloped
G proteins

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2
Q

Not- endemic

A

Australia (bat lyssavirus)
New Zealand
Great Britain
Ireland
Hawaii
Japan

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3
Q

N, P, M, G, L

A

N - Nucleoprotein gene
P - Cofactor of Polymerase
M - Inner virion protein used in budding
G - Glycoprotein that forms trimers - spikes
L - RNA - dependent - RNA - Polymerase

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4
Q

CNS

A

Minimal Histological sings
Negri bodies

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5
Q

Deaths

A

55K wordwide
2 in US

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6
Q

Canine Rabies

A

Eliminated in 1970s

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7
Q

Wildlife species

A

Raccoons
Bats
Skunks
Fox

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8
Q

Not common in

A

Rodents
Squirrels
Swine

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9
Q

Stability

A

Cool
Moist
Alkaline pH

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10
Q

Cold Chain

A

4C
50% glycerol in saline

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11
Q

Classification

A

Rhabdo - Lyssavirus

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12
Q

Genotypes

A

Based on N protein

7 Genotypes
-Classical
-Lagos - No human disease
-Mokola
-Duvenhage
-European bat lyssavirus 1 and 2
-Australina bat lyssavirus

4 Proposed
-Aravan
-Irkut
-Khujand
-West Caucasian Bat

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13
Q

Serogroup

A

Only ONE major Serogroup

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14
Q

Variants

A

Distinguished by G and G-L, N
Panel of monoclonal AB to N

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15
Q

Biotypes

A

Variants associated with Specific species
Highly adapted to species

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16
Q

Animal Variants

A

3 skunk
3 fox
1 coyote
1 racoon
2 bat
1 mongoose (PR)
Zero Dog

17
Q

Cycle

A
  1. Enter myocytes via nAchR
  2. Rep in myocytes -> Motor neuron NCAM
  3. Axonal Movement to CNS
  4. Limbic System - Furious - > Neocortex - Dumb
  5. Centrifugal spread to peripheral nerves
18
Q

Centrifugal spread from CNS

A

Salivary glands
Cornea
Internal organs
Nerve bundles in sensory hairs
Body Fluids
Death by respiratory arrest/paralysis

19
Q

Saliva

A

In saliva 10 days before overt signs (10 day quarantine)
Furious form may or may not be manifested

20
Q

Incubation

A

2 - 3 weeks up to 6 months or years

21
Q

Death

A

2 - 14 days after onset

22
Q

Additional signs

A

Can’t swallow
Pytalism (salivation)
Protrusion nictitating membrane
Hyperesthesia
Self Mutilation
Pica
Vocalization
Racoon - incoordination

23
Q

Histologically

A

Eosinophilc cytoplasmic inclusions
Negri bodies
Ammons horn

24
Q

Diagnosis

A

Presumptive - abnormal behavior
Definitive - FAT
Mouse inoculation MIT
VI using BHK
PCR - Negative not meaningful

25
Q

Control

A

Animal control
Vaccination of wildlife
Vaccination of domestic

26
Q

Exposure

A

10 day quarantine
Kill and submit to lab
Treatment if RV not ruled out

VMPM (14 decks)

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