Rabies Test Flashcards

(31 cards)

1
Q

What kind of virus is Rabies?

A

Enveloped RNA
Rhabdovirus Family
Lyssa virus genus

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2
Q

What kind of dz is Rabies?

A

Acute viral neurological dz that affects all mammals

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3
Q

What are the clinical signs of Rabies?

A
Encephalitis
Behavior change
Wound licking
Aggressive
Progressive paralysis
Death
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4
Q

Is Rabies Zoonotic? Reportable?

A

Yes, yes

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5
Q

What is Rabies resistance like?

A

Virus dies w/in 2 hours in dried saliva

Will survive in nervous tissue 24-48 hours at room temp

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6
Q

How does Rabies spread?

A
  1. Bites
  2. Non-bite exposure (scratches, abrasions, open wounds)
  3. Aerosol
    Virus NOT passed in blood, feces, urine
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7
Q

Does Rabies have a vector? Reservoir?

A

No, yes

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8
Q

What are the most susceptible species?

A

Raccoons
Bats
Skunks
Wild canids

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9
Q

What are the intermediate species?

A
Dogs 
Cats
Cows
Horses
Sheep
Goats
Humans
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10
Q

What are the most resistant species?

A

Primitive mammals (opossum)
Rodents
Squirrels
Rabbits

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11
Q

Is there a vaccine? If so, what kinds are available?

A

Yes
Parenteral: Humans and several other species
Oral: Licensed for use in wild species
*Given @ 3-4 months of age, boost 1 year after, and then yearly or every 3 years

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12
Q

Who is vaccinated?

A

Dogs, cats, and ferrets
Livestock
Horses if interstate transport

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13
Q

How do we stop transmission of Rabies?

A
  1. Vx domestic animals
  2. Remove strays/unwanted animals
  3. Regulate interstate/international movement
  4. Adjunct procedures
  5. Limit exposure to wildlife
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14
Q

What are some adjunct procedures in place?

A
Id
Licensure
Canvasina
Citations
Animal control
Public education
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15
Q

What if an unvaccinated domestic animal is exposed?

A

Euthanize immediately or put in ISO for 6 months

Vx immediately after exposure

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16
Q

What if a vaccinated domestic animal is exposed?

A

Revaccinate immediately

Observe on house arrest for 45 days

17
Q

What if an unvaccinated livestock is exposed?

A

Slaughter/euthanize

Stay away from milk and meat

18
Q

What if a human is exposed?

A

Clean wound
Notify local health department and family Dr.
Go to ER
*Even if previously vaccinated, still have to have post-exposure tx

19
Q

What if the animal that bit a human is healthy?

A

Confine and observe for 10 days
DO NOT VX
If signs occur: euthanize and submit head
If stray: euthanize and submit head

20
Q

What are the stages of infection for Rabies?

A
  1. Prodromal
  2. Excitative or Furious
  3. Paralytic or Dumb
  4. Death
21
Q

What does the Prodromal stage consist of?

A

Lasts about 2-3 days
Change in behavior or temperament
Pupils dilate, nictitating membrane visible, lick bite site

22
Q

What does the Excitative or Furious stage consist of?

A

Hypersensitivity to external stimuli, sounds, photophobia
Bite everything, very aggressive
Wander and roam

23
Q

What does the Paralytic or Dumb stage consist of?

A

2-4 days after first clinical sign appears
Ataxic or paralyzed- ascending paralysis
Have dropped jaw, drool, change in vocal sounds
Act like choking

24
Q

When does Death occur?

A

2-7 days after clinical signs appear
Die due to paralysis of respiratory muscles
Dz shuts down brain centers

25
What are the pathognomic signs of Rabies?
Change in behavior CNS signs Bite/scratch from wild animals
26
What is the incubation period of Rabies?
Varies: 2 days-1 year | Shedding of virus may occur 3-7 days before clinical signs appear
27
What is the best choice of testing for Rabies?
IFA Fewer false negatives Detects rabies before clinical signs appear Detects rabies in all species
28
What sample is needed for a Rabies test?
Brain tissue (intact)
29
What are other testing method for Rabies?
Histopathology Look for negri bodies (intracellular inclusions) in neurons Negri bodies don't appear until neurological signs appear Not commonly found in cats/ other species More false negatives *New rapid saliva screening test Not good or reliable
30
How do we ship the head?
DO NOT freeze or preserve head Double bag Leak proof container Label as biohazard/rabies sample
31
What is the Rabies tx in humans?
Post exposure prophylaxis (PEP) 1. Wash wound 2. Human diploid cell vaccine (HDCV) 3. Rabies immune globulin (RIG) (passive immunity) *Humans have CSF testing for live patients