Radiation Therapy and Aggressiveness of Cancers Flashcards by 873093 AP

Q

What are late effects of radiation therapy?

A

Infertility, cardiac toxicity, second cancers.

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Q

What is the median survival for Stage IV NSCLC?

A

12-14 months

All-comers, being treated with just chemotherapy, chemo + IO, Targeted therapies

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Q

What does performance status indicate?

A

A patient’s level of functioning and ability to care for themselves.

Indicator of how well a patient may tolerate cancer treatments, and plays a role in prognosticating.

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Q

What is prognosis of advanced NSCLC when no treatment is pursued?

Non-Small Cell Lung Cancer

A

Less than 6 months

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Q

Highly v. Lesser Aggressive Cancer

Pancreatic cancer

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Metastatic NSCLC without targetable molecular drivers, low PDL-1 expression

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Metastatic triple negative breast cancer

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Glioblastoma

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Extensive stage SCLC – initial rapid response to treatments but overall, not curable

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Advanced Stage Melanoma

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Angiosarcoma or certain high-grade soft tissues sarcomas

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Esophageal/Stomach cancers

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Cholangiocarcinoma

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

High grade ovarian cancer (high-grade serous carcinoma)

A

Highly Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Castrate sensitive prostate cancer

A

Less Aggressive

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Q

Highly v. Lesser Aggressive Cancer

Breast Cancer with ER+/PR+ hormone expression

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A

Less Aggressive

Q

Highly v. Lesser Aggressive Cancer

Thyroid cancer (papillary/follicular subtypes)

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A

Less Aggressive (can eventually develop to moderate aggressiveness due to resistance to therapies)

Q

Highly v. Lesser Aggressive Cancer

Basal Cell Carcinoma

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A

Less Aggressive

Q

Highly v. Lesser Aggressive Cancer

Carcinoid tumors

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A

Less Aggressive

Q

Highly v. Lesser Aggressive Cancer

Low-grade meningiomas

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A

Less Aggressive

Q

Highly v. Lesser Aggressive Cancer

GI stromal tumors (GIST, low risk subtype)

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A

Less Aggressive

Q

What are acute side effects of radiation therapy to the abdomen?

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A

Nausea, Vomiting, Diarrhea

Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.

Q

What are acute side effects of radiation therapy to the head & neck?

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A

Mucositis, Pain

Q

What are acute side effects of radiation therapy to the Thorax?

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A

Esophagitis

Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.

What are acute side effects of radiation therapy to the Pelvis?

Bowel / Bladder changes ## Footnote Tissues swell during the treatment, so can have side effects related to edema. These are all temporary, improves once the tissue swelling goes down and healing occurs.

What are acute side effects to radiation therapy?

Fatigue, pain ## Footnote Depends on location radiation is being delivered for other focal symptoms.