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Flashcards in Radiobiology 2 Deck (11)
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1

What does BED mean?

ratio of a and b in linear quadratic model to quantify fractionation sensitivity.

2

What does EQD2?

Equivalent total dose in 2 Gy

3

What is accelerated repopulation?

Treatment with any cytotoxic agent can trigger surviving cells in a tumour to divide faster than before

4

What happens if treatment is too long?

may compromise late fractions and trigger rapid repopulation

5

What the four types of fractionation?

Standard
Hyperfractionation
Hypofractionation
Accelerated fractionation

6

What are the advantages to prolonging treatment?

Spare early reactions and allow reoxygenation in tumours

7

What can excessive prolongation due?

Decrease the acute reactions and without sparing late reactions

Allows cells to proliferate during treatment

8

What is the rationale for Hyperfractionation?

Increase cell redistribution and re oxygenation
-Possible lower OER
-Different sparing of late reacting normal tissues

9

What is the accelerated treatment criteria?

reduce repopulation

10

What are unscheduled Interruptions?

Machine and staff availiability
-Public holidays
-Transport problems
-Medical problems
-social circumstance

11

Considerations for retreatment?

Dose and volume
Chemotherapy
]Time elapsed since treatment
Tissues and organs involved.
Can cause hotspots and coldspots