Radiopharm II

Question 1

According to the package insert what is the recommended maximum sodium pertechnetate activity and volume limits that should be used when compounding a Tc99m Sestemabi kit?

Answer 1

150 mCi Tc99m in a 1-3 ml volume

Question 2

According to the package insert what is the recommended maximum sodium pertechnetate activity and volume limits that should be used when compounding a Tc99m Tetrofosmin kit?

Answer 2

240 mCi Tc99m in a 4-8ml volume for the initial 10ml version and if using 30 ml formulation up to 2 Ci at no more than 80mCi/ml concentration

Question 3

Condition in which coronary flow decreases to a level below that needed to meet oxygen demand?

Answer 3

Myocardial ischemia

Question 4

[_____], [_____] myocardium can be restored to health by medical and surgical intervention.

Answer 4

Ischemic, viable

Question 5

What is the correct QC procedure for tetrofosmin?

Answer 5

One strip in 35:65 acetone: dichloromethane, cut strip in 3 sections, count each, bound drug in middle section

Question 6

QC procedure for Sestamibi?

Answer 6

One strip in ethanol, cut in half, count each, bound drug at solvent front and contaminants at origin

Question 7

Correct kit prep for Sestamibi?

Answer 7

1. Add tech in 1-3 ml volume
2. Boil
3. Add saline
4. Do QC

Question 8

Correct myoview kit prep?

Answer 8

1. Add tech and saline in one syringe with conc. Less that 80mCi/ml
2. Incubate at room temp for 15 mins
3. Do QC

Question 9

NOT an advancement of using tech over thallous chloride?

Answer 9

More rapid redistribution of the Tc99m agents

Question 10

NOT an advancement of using tech over thallous chloride?

Answer 10

Thallium has a higher energy and will show fewer attenuations

Question 11

Normal Sestamibi distribution?

Answer 11

Kidneys
Intestines
Bladder
Gallbladder wall
Tumor

Question 12

Sestamibi target organ

Answer 12

Upper intestinal wall

Question 13

Thallium target organ

Answer 13

Testes and thyroid

Question 14

Tertrofosmin distribution

Answer 14

Gallbladder wall
Intestines
Bladder wall
Kidneys

Question 15

Drugs that decrease Tl 201

Answer 15

Digitalis
Adriamycin
Furosomide
Propranolol

Question 16

Drugs that increase Tl 201

Answer 16

Dexamethasone
Sodium bicarbonate
Isoproterenol

Question 17

Tl 201 is used closer to its calibration time beca

Answer 17

The contaminants will be <2%

Question 18

Which drug redistributes

Answer 18

Thallous Chloride

Question 19

Tl 201 target

Answer 19

Myocardial tissue

Question 20

Which pharmaceutical has the highest extraction efficiency

Answer 20

Thallium

Question 21

What percent of Tl 201 localizes

Answer 21

3-4%

Question 22

What percent of Sestamibi or Tetrofosmin localize

Answer 22

1.2%

Question 23

T or F: Tl 201 is considered a cold spot marker

Answer 23

TRUE

Question 24

How does Tl 201 localize

Answer 24

Through a potassium analog

Na-K-ase pump

Question 25

How do tc99m agents localize

Answer 25

They stay trapped in the circulatory compartments.

Question 26

How does Tl 201 decay

Answer 26

Electron capture

Question 27

Other name for Lexiscan

Answer 27

Regadenoson

Question 28

According to the package insert when will Thallium EXPIRE

Answer 28

6 days following calibration

Question 29

When will Tetrofosmin expire following compounding

Answer 29

12 hours

Question 30

What mCi vial does Cardiolite come in

Answer 30

5ml vial

Question 31

What mCi vial does tetrofosmin come in

Answer 31

30 mCi vial

Question 32

After administration of 30mCi tetrofosmin dose, how much of the dose activity will localize in the myocardium?

Answer 32

<500 uCi

Question 33

Mechanism of localization for Tc99m agents

Answer 33

They appear to diffuse across cell membranes where they become fixed to cellular components