Raise Prolactin Flashcards by Shehla Hina

Q

Which drugs

A

Phenothiazines:

Prochlorperazine
Promethazine
Fluphenazine

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Q

Which drug

A

Metoclopramide

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Q

Which drug

A

Domperidone

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Q

Any similarity

A

Yes they all are antiemetics and can cause extra pyramidal effects - acute dystonia (hours to days), parkinsonism, akathisia, tardive dyskinesia

Tx of acute dystonia : anticholinergics - procyclidine

Acute dystonia happens due to increased acetylcholine due to low dopamine. Acetylcholine can cause excessive shaking. Anticholingic tackles this.

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