Random Flashcards
(22 cards)
What is the commonest inherited bleeding disorder?
Von-Willebrand disorder
Target cells, Howell-Jolly bodies, pappenheimer bodies are features on a blood film that would be seen in what condition?
Hyposplenism
Target cells and ‘pencil’ poikilocytes are blood films finding typical of what?
Iron deficiency anaemia
‘Tear-drop’ poikilocytes is a blood film finding typical of what?
Myelofibrosis
What are the 2 empirical antibiotics for neutropenic sepsis?
IV piperacillin and tazobactam
What is a myeloma a cancer of?
Plasma cells
What proteins are commonly found in the urine of someone with myeloma?
Bence Jones proteins
What may be seen on xray/MRI in someone with myeloma?
Osteolytic lesions, rain drop skull
What may be seen on a peripheral blood smear in someone with myeloma?
Rouleaux formation (stacking of blood cells on top of eachother)
Name 2 features of myeloma
- Hypercalcaemia
- Renal impairment
- Anaemia
- Increased infections
- Bone pain especially back
- Thrombocytopenia which increases bleeding risk
What mutation is associated with polycythaemia vera?
JAK2
Pigmented gallstones are associated with which cause of anemia?
Sickle cell anaemia
After a blood transfusion reaction, what is the most concerning sign implying a serious infection?
Hypotension
What blood profile is considered the universal donor?
AB Rh negative
What is given to patients with polycythaemia vera to decrease chances of clots forming?
Aspirin
Name 3 features of polycythaemia vera
- Pruritus especially after hot bath
- Hypertension
- Low ESR
- Splenomegaly
- Increased thrombosis risk
What is the management of idiopathic thrombocytopenic purpura?
Steroids
A sudden anaemia and low reticulocyte count in sickle cell anaemia indicates what infection?
Parvovirus
How is sickle cell anaemia diagnosed?
Hb electrophoresis
What paraprotein (Ig) is most commonly found in multiple myeloma?
IgG
What medication should be prescribed before starting chemo to reduce the likelihood of tumour lysis syndrome?
Rasburicase or allopurinol
Generally what’s the transfusion threshold re. platelets?
<70g\L in fit individuals, <80 in px with IHD
