Random Flashcards by Lisa Mullaney

Entities causing hemoglobinuria

Copper toxicity in sheep
Zinc toxicity
Acer rubrum
Leptospirosis
Babesia

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Stain for leptospirosis; location of leptospires

Warthin-Starry; PCT

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Leptospirosis virulence factors

Invasive motility (flagella)
LPS
Len (leptospiral endostatin-like) proteins (LigA, Plasma factor H, LipL32)
Hemolysin
Biofilm

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Where does Ehrlichia live?

Within monocytes

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Causes of white spotted kidney in the dog

Canine herpesvirus 1 (puppies)
Leishmania spp.
Borrelia burgdorferi
Hepatozoon canis
Canine adenovirus 1

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Causes of white spotted kidney in pigs

PRRSv
PCV2

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Causes of white spotted kidney in cattle

Calves- e.coli, salmonella, brucells, lepto
Malignant catarrhal fever
Theileriosis
Lumpy skin disease

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Cause of white spotted kidney in horses

Equine infectious anemia

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Causes of white spotted kidney in sheep

Sheep pox
Small animal lentivirus (maedi-visna)

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What breed has more severe Ehrlichia canis?

GSD

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Morph in kidney with ehrlichiosis

Plamacytic nephritis
Glomerular amyloidosis

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What unusual finding has been reported in canine leptospirosis?

Exudative glomerulonephritis

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Clostridium perfrigens type D toxins

Alpha toxin
Epsilon toxin**- toxic to endothelium and tubular epithelium

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Other organ affected in pulpy kidney disease

Brain (perivascular proteinaceous edema)

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Salmon bacteria

Renibacterium salmoninarum

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Most susceptible type of salmon to Renibacterium

Pacific

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Most resistant type of salmon to Renibacterium

Atlantic

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Histologic lesion with Renibacterium

Granulomas, macrophages contain coccobacilli

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Key histo feature with erysipelothrix rhusiopathiae

Embolic nephritis

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Pathology caused by Erysipelothrix (6 different systems)

Sepsis
Cutaneous
Polyarthritis
Endocarditis
Discospondyitis
Embolic nephritis

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Cause of pyelonephritis in pigs

Actinobaculum suis

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Erysipelothrix virulence factors

Neuraminidase
Capsular polysaccharide
Invasins
Surface proteins
SOD
Catalase

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Morphologic characteristics of Candida

Narrow based budding yeast
Parallel wall, sepatate hyphae
Pseudohyphae

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Aspergillus virulence factors

Beta glucan
Melanin
Ochratoxin A**- causes renal disease in pigs

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Aspergillus morphologic features

Septate Parallel walls Dichotomous acute angle branching

Who gets Cloisonne kidney?

Goats

What do Basenjis get?

Fanconi-like syndrome (PCT disorder with paradoxical glucosuria)

What is the key histo finding with Fanconi-like syndrome?

Marked hypertrophy and karyomegaly of tubular epithelium

Key histo finding with Cloisonne kidney

Gray/brown pigmentation of BM of PCT

Key histo finding with membranous glomerulonephritis

Spikes and holes (subepithelial ICs)

Who gets membranous glomerulonephritis?

Cats

Who gets proliferative glomerulonephritis

Horses

Who gets membranoproliferative glomerulonephritis?

Hereditary in pigs C3 deficiency in Finnish Landrace sheep and Brittany spaniels

Key histo findings with membranoproliferative GN?

Double-contoured BM "tram tracks" associated with intramembranous or subendothelial ICs

PTH effects on Ca/P

Increases Ca resorption, decreases P resorption Increases bone resorption, decreases bone deposition Overall, increases Ca, decreases P Increases calcitriol (by increased 1alpha hydroxylase aka vit D production by kidney), thereby increased GI absorption of Ca and phos

Calcitriol effects on Ca/P

Increases Ca and Phosphorus overall Increases bone resorption Increases absorption of Ca and Phos in GI

Most common amyloid in domestic species

What mice are resistant to AA amyloid?

A/J mice

What breeds get familial AA amyloidosis?

Shar pei (medullary) Abyssinians (medullary, glomerular) Siamese (liver, kidney)

Key histo findings in chronic progressive nephropathy (rats)

Chronic changes in all parts of nephron, metastatic mineralization (only in rats, not mice)

Rat breeds predisposed to chronic progressive nephropathy

Sprague-Dawley Fischer 344

Key histo findings with diabetic nephropathy

Glomerulosclerosis Glycogen change Lipid emboli and fat vacuoles in mesangium

Key histo findings with glomerular lipidosis

Foam cells in mesangium (microvacuoles in cystoplasm)

Key histo finding in gout

Urate tophi (pathognomonic)

Key histo findings with renal dysplasia/progressive juvenile nephropathy (6)

Fetal glomeruli Primitive mesenchyme Blind ending collecting ducts Persistent metanephric ducts Adenomatoid epithelial proliferation Osseous metaplasia (rare)

Who gets Gilbert syndrome (congenital hyperbilirubinemia)

Southdown sheep

Aspergillus virulence factors

Ochratoxin-A (causes renal dz in pigs) Beta glucan Melanin

Key histo findings with hypertensive arteriosclerosis

Glomerulosclerosis Proliferative arteriosclerosis (onion skinning) Hyaline arteriosclerosis

Who gets autosomal dominant polycystic kidney disease?

Bull terriers Persian cats

Who gets autosomal recessive polycystic kidney disease?

West Highland and Cairn terriers Perendale sheep

Autosomal dominant PCKD is linked to

PKD-1 and PKD-2 genes

Autosomal recessive PCKD is linked to

PKHD1 gene

Lab animal prone to renal congenital cysts

BALB/C mice

Key histo feature with Chediak-Higashi Syndrome

Large, PAS positive granules in leukocytes, platelets, hepatocytes, renal tubular epithelium, neurons, endothelial cells, melanocytes

Cause of Chediak-Higashi Syndrome

Autosomal recessive defect of LYST or Beige gene causes abnormal lysosomal trafficking

What histo finding occurs with Gilbert's syndrome?

Progressive fibrosing interstitial nephritis

Cause of Gilbert's syndrome

Type III photosensitization

What type of GN is associated with Borrelia? Other histo findings?

Membranoproliferative GN; tubular changes, lymphoplasmacytic interstitial nephritis

Where does leptospira interrogans hide?

PCT

Leptospirosis virulence factors

Invasive motility (flagella) LPS Len (Leptospiral endostatin-like) proteins (LigA, plasma factor H, LipL32) Hemolysin Biofilms

Key histo with lepto

Acute- Neutrophilic tubulointerstitial nephritis Chronic- lymphoplasmacytic tubulointerstitial nephritis

Key histo with Ehrlichia canis

Plasmacytic nephritis***

Cytotoxic venom

Vipers

Neurotoxic venom

Elapids

Hemotoxic venom

Colubrids

Key histo with snake envenomation

Dilated and ruptured glomerular capillaries (mesangiolysis) Tubular degeneration and necrosis

What is the toxin that causes acquired alpha mannosidosis?

Swainsonine

What plants have endophyte that produces swainsonine

Broomweed (Sida carpinifolia) Astragalus Oxytropis Swainsona

Who gets alpha mannosidosis?

Angus, Murray, Galloway cattle Persian cats

Who gets beta mannosidosis?

Salers cattle Nubian goats GSDs (MANBA gene defect)

Key histo with mannosidosis

Marked cytoplasmic vacuolation of PCTs

Normal finding in macaques

Syncytial cells in renal collecting tubules

Where does chronic polypoid cystitis occur?

Cranioventral wall of bladder

Who gets nephroblastomas?

Swine, chickens, fish Cats and dogs less often

Paraneoplastic syndrome in dogs with nephroblastoma

polycythemia,

Tumor in german shepherd dogs

Ectopic nephroblastoma in thoracolumbar spinal cord of young dogs

Key histo features of nephroblastoma

Epithelial- blastemal cells Mesenchymal- loose spindle cell stroma/ fibrous, mucoid, adipose, cartilage, bone Primitive glomeruli Abortive tubules

Renal cell carcinoma most common primary renal tumor in

Dogs, cattle, horses

RCC has a low metastatic rate in one species, which is it?

Cattle

What breed gets renal cyst/adeno- carcinoma and nodular dermatofibrosis due to mutation in Birt-Hogg-Dube gene?

GSD

RCC is virally induced by

Ranid herpesvirus-1 Avian erythroblastosis

What lab breed is predisposedto RCC ?

Longs-Evan (Eker) rats

What paraneoplastic syndromes does RCC cause?

Polycythemia; hypertrophic osteopathy if pulmonary metastasis

Infectious causes of ICGN in dogs

Canine adenovirus 1 Dirofilaria immitis Borrelia burgdorferi Leishmania infantum Babesia gibsoni

What breed gets canine familial glomerulonephritis

Bernese Mountain dog

Infectious causes of ICGN in horses

Streptococcus equi Herpesvirus Equine infectious anemia

Infectious causes of ICGN in cats

Feline leukemia virus and hematopoeitic tumors

Noninfectious causes of ICGN

Heavy metal toxicosis (gold)

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