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1
Q

underlying cause of pemphigus

A

antibodies to desmogleins

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2
Q

underlying process of pemphigoid

A

antibodies to hemidesmosomes

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3
Q

desmogleins

A

adhesion molecule between epithelial cells in the skin

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4
Q

igg deposition between cells in epidermis

A

pemphigus

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5
Q

chicken wire appearance

A

pemphigus

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6
Q

igg antibodies to basement membrane

A

pemphigoid

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7
Q

negative nikolsky sign

A

pemphigoid

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8
Q

which diseases show koebners phenom

A

psoriasis
vitilgio
lichen planus

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9
Q

first line in acne

A

topical retinoid adn topic antibiotic

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10
Q

what is not recommended in acne

A

corticosteroids

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11
Q

hemidesmosomes proteins in pemphigoid

A

bp180 and bp230

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12
Q

investigatin for contact dermatitis

A

patch test

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13
Q

first line managemrnt for dh

A

dapsone

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14
Q

acne first line treatment

A

Topical Benzoyl Peroxide and Adapalene combination

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15
Q

side effect of isotretinoin

A

skin fragility

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16
Q

what is nail pitting assoc with

A

psoriais
exzema
alopecia

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17
Q

5 ps for lichen planus

A

Purple
Pruritic
Papular
Polygonal
Planar (flat topped)

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18
Q

ladder of meds for acne

A

topical treatments, abx, retinoida

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19
Q

withdrawl of steroids is a recognised trigger of what

A

psoriaiss

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20
Q

classification for ceullulitis

A

eron clasification

Class 1 (systemically well, no comorbidities), Class 2 (systemically unwell/poorly controlled comorbidities), Class 3 (SIRS/very poorly controlled comorbidities), Class 4 (septic shock/life-threatening infection).

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21
Q

treatment for pregnant owman with cellulitis

A

erythromycin.

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22
Q

what is tractin alopecia due to

A

hairstyles

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23
Q

alopecia

A

localised non scarring alopecia

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24
Q

whole scalp alopecia name

A

sotalis allopecia

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25
trichotillomania causes
self induced pcikign hair out
26
where is tinea captis seen in
areas of poverty
27
what is tinea captis
fungal infection on scalp
28
what is kerion
immune repsonse to fungal infecion on scalp severe
29
lanugo hair type
fine long hairs covering the foetus shed about one month before birth
30
vellus hair type
fin eshort hair covering much of body surfaces replaces lanugo hairs before birth
31
terminal hair type
long coarse hairs e.g scalp growth influenced by androgen levels
32
autoimmune cause of hair loss
alopecia areata
33
first line t5reatment for alopecia areata
potent or super potent topical corticosteroid - clobetasol, dermovate
34
drugs linked to bullous pemphigoid
Spironolactone, Furosemide, Sulfasalazine, Penicillins, Beta-blockers, Antipsychotics and Enoxaparin.
35
first line treatment for rosacea
ivermectin
36
scaly plaques
squamous cell
37
visible telangiectasia
basal cell carcinoma
38
what setting does a marjolin ulcer occur in
squamous cell carcinoma in the history or traumatised skin
39
type of melanoma on shins
superficial spreading
40
melanoma on nail bed
subungal
41
melanoma on palms, soles and nail beds
acral lenitngiuso
42
melanoma most commonly found on trunk and most aggressive
nodular
43
melanoma most common in elderly due to orolonged sun exposure
lentigo
44
biggest risk factor for developing bcc
immunosuppression
45
bresllow thickness
from granular layer to deepest invafding cell
46
what does phaemelanin cause
red hair
47
what does MC1R dtermine
balance of pigment in skin and hair
48
what does one defective copy of mc1r cause
freckkles
49
what does two defective copies in mc1r gene cause
red hair and freckles
50
fitzpatrick skin phototypes
I Only burns II Burns, can tan III Tans, can burn IV Tans V Dark brown skin VI Black skin
51
what does the spf factor relate to
how effectively they block UVB
52
UVA v UVB
UVB is. ashort wavelenght only reaching in summer months UVA longer wavelength
53
what uv do we have most exposure to
UVA
54
what is a photon of UVR absorbed by
dna in nucleus of keratinocyte
55
which uv is more dangerous a or b
b
56
what ahppens to p53 with more sun damage
mutant p53 clones increase in number and size
57
what do keratinocytes secrete
il-10 and other immunosuppressive molecules
58
polymorphic light eruption
reaction rash to the sunn
59
what is xeroderma pigmentosum charaterised by
severe photosensitivity, skin pigmentary changes, malignant tumor development,
60
complication of eczema
eczema hyperticum usually due to herpes clusters of red blisters itchy and painful
61
management of eczema hyperticum
usually hopsital admission
62
target antigens in pemphigus
desmogleins 1 and 3
63
when to apply emollient in eczema
post shower
64
fusidic acid use
impetigo
65
what is eczema herpeticum treated with
intravenous aciclovir as it is an antiviral
66
treatment for urticaria
non-sedating antihistamines such as Cetirizine/Loratidine/Fexofenadine
67
where do venous ulcers present
gaiter area - lowr leg
68
where do arterial ulcers present
foot
69
normal a bpi
between 1 and 1.4
70
streptococaanl infection involing epidermis making brihgt red on face and puffy
erysipleas
71
3 month old - fever, irritability, extensive blistering around mouth, armpit groin
Staphylococcal scalded skin syndrome
72
example of a retinoid
oral isotretinoin
73
second line for severe acne
2 antibiotics then a retinoid
74
what alopecia is stress an important factor in
areata
75
abnormal skin sensations and pain, followed by a unilateral vesicular rash in the affected dermatome
shingles
76
treatment for bowens
imiquimoid
77
MOA of clopidogrel
antagonist against adp receptor
78
what is used to monitor unfractioned heparin
aptt
79
what is dermatoscopy
exammination of the skin using a camera like tool
80
what are patients with scleoris at risk of developig
pulmonary hypertension
81
known porphyrinogenic
trimethoprim
82
drugs involved in plaque psoriasis
beta blcokers
83

Dermatology (15 decks)

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