Random .2 Flashcards by abbey hart

MOA of rituximab

antibody whcih targets and kills cd20 positive b cells so works in b cell lymphomas

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which anaemia causes koilonychia

iron def

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worse afer hot bath

polycythaemia vera

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first line investiugaton in GCA

plasma viscosity or esr

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what is VWF a carrier for

factor 8

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characteristics of myeloma

CRABBI
calcium rasied
renal imapirment
Anaemia,
Bones
Bleeding (thrombocytopaenia), and Infections (neutropaenia).

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blood results of myeloma

hypercalcqemia
normal/ raised phosphate
normal alp

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what can increase life span of red blood cells and so increasing hba1c

splenecomty

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what does pernicous anaemia predispose to

gastric cancr

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starry sky appearance

burkitts

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multiple myeloma characteristics

roleoux formation, hypercalcaemia, anaemia, back pain- CRABBI pneumonic

confirmed with electrophoresis

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first line management for warm autoimmune haemolytic anaemia

steroids and rituximab

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first line chronic myeloid leukaemia

imatinib

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do all myelomas show on electrophoresis

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how is vaso occlusive crisis confirmed

doesnt need confirmation
confirmed via pain clinically

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gold standard for non hodgkins

pet/ ct

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heinz bodies

g6pd def

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prophylactic drug for sickle cell

hydroxyurea

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howell jolly bodies

coelic , hyposlenism

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rivaroxaban moa

direct factor Xa inhibitor

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taco v trali

trail is hypo taco is hyper

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hand foot syndrome

swelling of hands and feet of child with sickle cell

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what is taco treated with

loop diuretics

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how is richters tranformation diagnosed

lymph node biopsy

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first line treatment for ITP

oral prednisolone

what is autoimune haemolytic anaemia characterised by

coombs test

what transfusions are at risk of bacterial infection and why

platelets as they are stored at room temp

what is used for reversal of doac in patients with severe bleed/ head injury

prothrombin complex concentrate

what can cause an isolated rise in hb

polycythaemia vera

what is HIV a risk for in tersm of cancer

non hodgkins

isolated rise in ggt in macrocytic anaemia

alcoholism

Exchange transfusion role

reduce number of sickle cells and increase numbe rof normal cells to improve oxygenation

what might methptrexate therapy result in

megaloblastic macrocytic anaemia

bite and bloster cells

g6pd

what type of cancer might polycythaemia rubra vera transform to

acute myeloid leukaemia

investiagtion for non hodgkins

excisional node biopsy

blue lines on gum margin

lead poisoning

What type of anaemia does sickle cell cause

normocytic rlow haemoglobin, normal nbc, raised retic

raised hba2 in terms of thalassaemias

beta trait

does alpha trait cause a raised hba2

what type of drugs have adverse effect on g6pd patients

sulfa containing drugs

what does a high tibc suggest

low iron in blood as there are more spots to fill up

aplastic crisis

sudden drop in hb

what should sickle cell patients be commeneced on to prevent crisis

hydroxycarbamide

what can rivaroxaban and apixaban be revrsed by

andexanet alfa

is fibrinogen high or low in dic

low

what counteracts warfarin

vit k

first line in polycythaemia vera

venesection- phlebotomy

blood film of folate def

hyper segmented neutrophisl

risk factor for non hodgkins

HIV

does trali present with abdo pain

acute haemolytic reaction symptoms

tachycardia, abdominal pain, fever, hypotension

what is creatinine

waste product of ormal muscle metabolism breakdown

protein def in ttp

ADAMTS13

massive splenomegaly

chronic myeloid leukaemia

translocation in cml

9, 22

what might ileocacael result in

b12 def

beefy red tongue

b12 def and folate

acquired haemolysis main note

prolonged aptt

first line for warm autoimmune haemolytic anaemia

steroids +/- rituximab

medication for patients with polycythaemia vera to reduce dvt

aspirin

treatment for aps during pregnancy

aspirin and lmwh

what can polycythaemia rubra v lead to

aml or myelofibrosis

most causative organsim in neutropenic sepsis

staph epi

definitive diagnosis for sickle cell

electrophoresis

what is alteplase used in

emergency situations

what does cryoprecipitate contain

VWF, factor viii, fibrinogen and factor xiii

which cancer has potential to involve CNS, testis and other extra marrow sites

ALL

sequestrian criss retics

high

aplastic crisis retics

low

diagnostic for cll

bone marrow biopsy ansd immunophenotyping

what are cabot rings highly suggestive of

pernicous anaemia

in kids how does itp usually present

post viral infection self limitting

slapped cheek appearance

parvovirus b19

what might haemolytic crisis be precipitated by

infection

what factors does vit k inhibit

2,7,9,10 same as warfarin

difference between vit k and warfarin

warfarin is anti coag and vit k promotes clotting

dry tap

myelofibrosis

what investigation would confirm aplastic anaemia

bone marrow biopsy

factor what def is most likely to result in prolonged pt time

vii