Random Stuff I can't get

Question 1

11:14 translocation?

Answer 1

mantle cell lymphoma

Question 2

IgH next to Cyclin D1?

Answer 2

Mantle cell lymphoma

Question 3

CD25 and CD11c

Answer 3

Hairy cell leukemia

Question 4

Popcorn cells

Answer 4

Nodular Hodgkins lymphohma

Question 5

8:21 translocation?

Answer 5

AML with neutrophilic maturation seen in young patients with a good prognosis

Question 6

RUNX-RUNX1T1?

Answer 6

AML t(8:21) seen in younger patients good prognosis, neutrophilic maturation

Question 7

15:17?

Answer 7

APL subclass of AML has auer rods

Question 8

PML-RARa?

Answer 8

APL tx with retionic acid

Question 9

ALK+ or ALK-?

Answer 9

ALCL

Question 10

Cloverleaf assoc. with HTLV-1

Answer 10

Adult T cell

Question 11

9:22

Answer 11

CML

Question 12

Tennis Racket Birbek granuels

Answer 12

Langerhans Cell Histiocytosis

Question 13

8:14

Answer 13

Burkitts

Question 14

IgH/MYC

Answer 14

Burkitts

Question 15

Tingible Body macrophages?

Answer 15

Burkitts

Question 16

12:21

Answer 16

ALL, good prognosis

Question 17

Arrest of lymphocytic cells, large dark nucleus, agranular, dense packed bone marrow, TdT present on cells

Answer 17

ALL common in kids

Question 18

Undergoes RIchter transformation with mutations involving P53 or MYC

Answer 18

CLL/SLL

Question 19

14:18

Answer 19

Follicular lymphoma

Question 20

IgH/BCL-2

Answer 20

Follicular lymphoma

Question 21

Painless lymphadenopathy IgH translocated next to BCL2?

Answer 21

Follicular lymphoma

Question 22

PIGA mutation

Answer 22

PNH

Question 23

Howell Jolly bodies?

Answer 23

HS

Question 24

Heinz bodies?

Answer 24

G6PD deficiency, Hgb denatured

Question 25

High homocystein levels only

Answer 25

Folate deficiency

Question 26

High homocystein and MM/CoA

Answer 26

B12

Question 27

Low serum iron ferritin and hepcidin, but high TIBC

Answer 27

IDA

Question 28

Low serum iron and TIBC with increased serum ferritin

Answer 28

Anemia of Chronic Dz

Question 29

Pure red cell aplasia

Answer 29

Diamond Blackfan syndrome

Question 30

Pentad of symptoms for TTP

Answer 30

``` Fever Thrombocytopenia MAHA Neuro deficits Renal failure ```

Question 31

ADAMTS13 mutation?

Answer 31

TTP

Question 32

Splenomegaly, increased buffy coat, mature myeloid cell proliferation?

Answer 32

CML

Question 33

occurs at all ages, >20% blasts in bone marrow, fever, fatigue, bleeding, may or may not have blasts in peripheral smear, 8:21 or 15:17

Answer 33

AML

Question 34

Auer rods

Answer 34

APL 15:17

Question 35

Reed sternberg cell markers?

Answer 35

CD15 CD30 Pax-5

Question 36

Rouleaux formation?

Answer 36

Hyperviscosity seen in hyperIg in Multiple Myeloma

Question 37

Epoetin alfa toxicities?

Answer 37

Increased risk of MI, death, stroke, VTE, tumor progressioni

Question 38

Hydroxyurea toxicities?

Answer 38

Neutropenia, oral ulcers, hyperpigmentation, mild GI upset

Question 39

Eculizumab toxicities?

Answer 39

viral infections, lie threatening meningococcal infections, immunogenic, URT infections, msk pain, anemia, leukopenia, htn, HA, insomnia/fatigue, UTI

Question 40

What does Eculizumab do?

Answer 40

Inhibitis terminal complement mediated intravascular hemolysis used in PNH, its only available under REMS

Question 41

Filgrastim toxicities? How/when to administer?

Answer 41

Bone pain, allergic reaction | IV infusion 24 hrs after chemo

Question 42

Sargramostim toxicities?

Answer 42

edema, sequestration of granulocytes in pulmonary circulation causing dyspnea, worsens existing renal and hepatic dysfunction, has benzyl alcohol causing fatal gasping syndrome in premies

Question 43

Oprelvekin toxicities?

Answer 43

significant edema, cardiac dysrhythmias, severe allergic rxn, blood shot eyes

Question 44

Romiplostim toxicities?

Answer 44

well tolerated most serious concern is allergic rxn

Question 45

Romiplostim pharmacokinetics?

Answer 45

weekly administration as a SC injection

Question 46

What drug is used in healthy individuals with thrombocytopenia or individuals with ITP after failure of glucocorticoids and immunoglobins?

Answer 46

Romiplostim