Rate-Determining Enzymes of Metabolism Flashcards Preview

Biochemistry > Rate-Determining Enzymes of Metabolism > Flashcards

Flashcards in Rate-Determining Enzymes of Metabolism Deck (13):
1

Glycolysis

Phosphofructokinase-1 (PFK-1)
AMP +, fructose-2,6-bisphosphate +
ATP -, citrate -

2

Gluconeogenesis

Fructose-1,6-bisphosphatase
ATP +, acetyl-CoA +
AMP -, fructose-2,6-bisphosphate -

3

TCA cycle

Isocitrate dehydrogenase
ADP +
ATP -, NADH -

4

Glycogenesis

Glycogen synthase
Glucose-6-phosphate +, insulin +, cortisol +
Epinephrine -, glucagon -

5

Glycogenolysis

Glycogen phosphorylase
Epinephrine +, glucagon +, AMP +
Glucose-6-phosphate -, insulin -, ATP -

6

HMP shunt

Glucose-6-phosphate dehydrogenase (G6PD)
NADP+ +
NAPDH -

7

de novo pyrimidine synthesis

Carbamoyl phosphate synthetase II
ATP +
UTP -

8

de novo purine synthesis

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase
AMP -, IMP -, GMP-

9

Urea cycle

Carbamoyl phosphate synthetase I
N-acetylglutamate +

10

Fatty acid synthesis

Acetyl-CoA carboxylase (ACC)
Insulin +, citrate +
Glucagon -, palmitoyl-CoA -

11

Fatty acid oxidation

Carnitine acyltransferase I
Malonyl-CoA -

12

Ketogenesis

HMG-CoA synthase

13

Cholesterol synthesis

HMG-CoA reductase
Insulin +, thyroxine +
Glucagon -, cholesterol -