Rbc

Question 1

Most common hematologic abnormality a/w HIV infection?

Answer 1

Anemia

Question 2

Which contains most of functional iron in body?
a) hemoglobin
b) myoglobin
c) transferin
d)ferritin

Answer 2

Hemoglobin

Question 3

Haptocorin and cubulin a/w?

Answer 3

Vit B12 absorption

Question 4

Mcc of aplastic anemia

Answer 4

Autoimmune

Question 5

Microcytic anemia failing to respond to iron therapy

Answer 5

Tmprss6 mutation ( norml function is to supress hepcidin production when iron is low)

Question 6

Tranferin receptor mrna conc amd ferritin mrna conc in iron deficient state

Answer 6

Increase
No change

Question 7

Mentzer index formula and value in ida

Answer 7

Mcv/rbc count
More than 13

Question 8

Se. Transferin receptor/log se. Feritin in ida

Answer 8

> 1.5

Question 9

Corected reticulocyte formula

Answer 9

Given reticulocyte* patient hb / hb of norml age

Question 10

Mc infectious cause of aplastic anemia

Answer 10

Viral hepatitis

Question 11

Anemia on metastatic cancer

Answer 11

Myelopthisic anemia

Question 12

Hbs mutation and Hbc mutation

Answer 12

Point mutation
Hbs glutamic acid replaced by valine
Hbc glutamic acid replaced by lysine

Question 13

Happene in alpha thalasemia

Answer 13

Gene deletion

Question 14

Mutation in beta thallesemia

Answer 14

Gene mutation

Question 15

Most common mutation of beta thallesmia

Answer 15

Splicing mutation

Question 16

Hb range in thall intermediate and Major

Answer 16

Intermediate - 6 to 9 h/o blood transfusion

Major - <6 no hist

Question 17

Chipmunk facial appearance seen in

Answer 17

Beta thall major

Question 18

Hbf vs Hba2 kon se thallesemia m kon sa badta h

Answer 18

Hbf increase in thall major

Hba2 increase in thall minor/trait

HbA to decrease hota hi hai

Question 19

Osmotic fragility increase in

Answer 19

Hereditary spherocytoIS

Question 20

Osmotic fragility decrease in

Answer 20

Sickle cell
Thallesmia

Question 21

Gene for alpha and beta chains

Answer 21

16 and 11

Question 22

HbH disease m which tetramer

Answer 22

Beta 4
Golf ball apperance

Question 23

Barts Hb

Answer 23

Gamma 4 tetramer
Baby dies in 3rd trimester
Non immune hydrops fetalis

Question 24

PNH gene, anchor protein, transmembrane Protein

Answer 24

Piga gene
GpI protein provide anchor to cd59, cd55,c8b

Question 25

Membrane inhibitor of reactive lysis

Answer 25

CD 59

Question 26

Thrombosis seen in

Answer 26

Sickle cell anemia PNH

Question 27

C3 converstasw inhibitor

Answer 27

Cd59 aka mem inhibitor of reactive lysis

Question 28

Mcc of death in pnh

Answer 28

Thrombosis budd chiari

Question 29

C5 inhibitor drug

Answer 29

Eculizumab

Question 30

Antibody in warm and cold AIHA

Answer 30

IgG igM

Question 31

Drugs causing aiha

Answer 31

Methyl dopa Penicillin Quinidine

Question 32

Spherocyte most commonly seen in

Answer 32

Aiha

Question 33

Cause of extravascular hemolysis in cold AIHA

Answer 33

Igm mediated complement activation C3b attach to rbc which gets destroyed

Question 34

Cold aglutinin disease

Answer 34

Igm against I antigen of rbc

Question 35

Cold hemolysin type disease

Answer 35

IgG against p antigen of rbc

Question 36

Donath landsteiner antibio

Answer 36

IgG against P antigen of rbc

Question 37

Cold aiha type and respective hemolysis

Answer 37

Hemolysin type me intravascular Agglutinin type me extravascular

Question 38

Biphasic erythrocytic antibody

Answer 38

Cold hemolysin IgG aginst P ag of rbc 4 degree p bind 37 degree p complement activation damage

Question 39

Aplastic anemia a/w or progresses to

Answer 39

Mds Aml