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Rbc Flashcards

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1
Q

Is retic count >3

A

Hyperproliferative anemia

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2
Q

If retic count < 3

A

Hypoproliferative anemia

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3
Q

For hypoproli next inv is

A

Mcv

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4
Q

Mcv normal

A

80 t0 102
<80 microcytic
>102 macrocytic

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5
Q

Microcytic

A

SITA
sideroblastic
Ida
Thalassemia
Anemia of chronic dx

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6
Q

For microcytic what is the bext step

A

Challenge oral iron for 1 week
Then do retic count

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7
Q

After challenge oral iron if retic count inc

A

Ida

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8
Q

If ida tx for how long

A

Oral iron for 6 to 12 months

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9
Q

After challenge oral iron no response in retic count dd

A

SITA
Do iron profile

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10
Q

Tests of iron profile

A

Sr. iron
Sr ferritin
Tibc
transferrin saturation

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11
Q

All dec except tibc

A

Ida

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12
Q

Other inv for ida

A

Inc sr.tfr 1 and protoporphyrins

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13
Q

Inc in sr. Tfr 1 is

A

Most specific for ida but late finding

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14
Q

Earliest test for ida is

A

Sr. Ferritin

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15
Q

For ida due to malabsorption mx

A

Inj. Iron
New form- iron maltose. Ferric carboxy maltose
Imp of this.. single shot inj

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16
Q

All dec except sr. Ferritin dd

A

Anemia of chronic dx
Inc esr crp tlc

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17
Q

All inc except tibc

A

Sideroblastic anemia

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18
Q

Cause of sideroblastic anemia

A

Bm will have sideroblasts

Lead poisoning- pappenheimer bodies seen
Vit b6 and cu def
Treat def

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19
Q

All iron profile normal na

A

Thalassemia minor

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20
Q

Thal minor test

A

Hplc will show hbA2 inc

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21
Q

Mx of thal minor

A

Genetic counselling. Genetic testing
In preg… amniocentesis done. If heterozygous cont preg
Homozygous.. mtp done

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22
Q

If mcv normal

A

Normocytic anemia

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23
Q

Normocytic anemia divided into

A

Retic count 1-3% no pancytopenia
Retic count <1% pancytopenia+

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24
Q

Retic count <1% + pancytopenia

A

Aplastic anemia

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25
Retic count 1-3% no pancytopenia
Anemia of hemodilution Anemia of crf
26
In aplastic anemia findings
Bone marrow dry tap in aspirate Bm biopsy shows only fat
27
Tx aplastic anemia
Bm trasplant
28
Macrocytic anemia mcv>102 dd
Hypersegmented neutrophils+ - megaloblastic vit b12 folste def No hypersegmented neutrophils- liver dx thyroid dx
29
Macrocytic anemia neuro mani, ileal dx , gastrectomy, pernicious, veg, hyperpigmentex knuckles, inc methyl melanoic acid , homocystinemia
Vit b12 def
30
Vma inc in
Paragangliomas, pheochromocytoma
31
No veg in diet alcoholic malig inflamm preg celiac tropical sprue
Folate def
32
Hyperproliferative anemia rc>3%
Hemolytic anemia
33
Hemolytic anemia types
Child - inherited - spherocytosis, her spherocytosis, thalasemmia, g6pd def, sickle Adult- acquired
34
Cf of child inherited hemolytic anemia Hemoglobinuria after oxidative stress -
G6pd def
35
Hemolytic anemia with splenomegaly. Onset at birth
Her spherocytosis
36
Hemolytic anemia hemolytic facies splenomegaly no onset at birth
Thal major
37
Hemolytic anemia splenomegaly vascular crisis+ no onset at birth
Sickle cell dx
38
Inv for her spherocytosis
Osmotic fragility test Spherocytes in peripheral smear
39
Tx for her spherocytosis
Splenectomy
40
Inv thalassemia
Target and tear drop cells peripheral smear
41
Ioc fi4 thalasemmia
Hplc - hbf inc Hba dec
42
Tx of thalasemmia
Blood transfusion
43
Inv for sickle cell anemia
Peri smear shows target and sickle cells Hplc shows elevated hbs dec in hba
44
Tx for sickle cells
Hydroxyurea L glutamine Intermittent blood transfusion Gene therapy
45
Inv for g6pd def
Perip smear shows bite cells heinz bodies
46
47
Tx for g6pd def
Avoid oxidative stress
48
In adult acquired hemolytic anemia
AIHA PNH
49
Adult hemolytic anemia h/o autoimmunity
AIHA Clumping of rbcs, spherocytes
50
Adult hemolytic anemia h/o hemoglobinuria, thrombosis, thrombocytopenia. Pancytopenia+-
PNH
51
Test for AIHA
Coombs test
52
Tx for AIHA
Steroids and tx cause
53
Test for pnh
Flow cytometry- CD 55 and 59 are negative
54
Tx for pnh
Eculizumab - monoclonal ab to c5
55
Anemia + celiac dx
Ida and folate def
56
Anemia + achlorhydria
Ida b12 def
57
Anemia + leucocytosis
Anemia of chr dx
58
Anemia + inc ferritin
Sideroblastic ,ACD
59
Anemia + inc sr iron
Sideroblastic
60
Anemia + dec ferritin
Ida
61
Anemia + jaundice
Hemolytic anemia
62
Anemia+ splenomegaly
Hemolytic, mylopthysis, b12 def
63
Anemia+ splenomegaly + jaundice
Hemolytic , b12 def
64
Anemia+ dark urine
Intravascular hemolysis
65
Anemia+ fragmented rbcs[ schistocytes]
Microangiopathic hemolytic anemia, prosthetic valves
66
Anemia + jaundice right from birth
Her spherocytosis
67
Anemia after drugs
AIHA, g6pd
68
Anemia + spherocytosis
Her spherocytosis, AIHA, g6pd
69
Anemia+ Thrombocytopenia
PNH aplastic mylopthysic
70
Pancytopenia no hep splenomegaly anemia
Aplastic, mds
71
Pancytopenia with hep splenomegaly
Myelofibrosis
72
Cells lyse more in osm fragility test
Spherocytes and eliotocytes
73
Osmotically less fragile are
Sickle cell and thalasemmia
74
Nestroff test used in
Population screening of thal minor
75
Sickle solubility test
To test sickle cell carrier or trait
76
Content of golf ball rbc
Hbh beta4
77
Golf ball rbc seen in
Alpha thalasemmia
78
Spl stain for sideroblastic anemia in bm aspirate
Prussian blue stain
79
Tx for aplastic anemia
Mild - steroids Severe- hemotopoietic stem cell transplant
80
Hemoglobinuria after antibiotics use
G6pd def
81
Heinz bodies seen only in
Supra vital stains
82
Mycoplasma pneumonia pt. Peripheral smear seen. Heme agglutination seen
AIHA COLD IgM related
83
Wbc pipette
11 marking 20x dilution Wbc and plt count
84
Rbc pipette
101 marking 200x dlitution Rbc count
85
Fluid for rbc
Hyames fluid
86
Fluid for wbc
Turks fluid
87
Fluid for plt
Rees eckers fluid
88
Dec albumin Dec alpha Beta - normal Gamma inc Beta gamma bridge
Cirrhosis
89
Inc alpha1 alpha 2
Acute inflammation
90
Less albumin Alpha 2 inc Alpha 1 gamma slightly dec Beta inc or dec
Nephrotic syndrome
91
Only gamma spike
Monoclonal spike... myeloma
92
Gamma just broad elevation
Polyclonal gammopathy.. chronic inflammation

Pathology (5 decks)

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