RBC anomalies

Question 1

It refers to erythrocytes with normal amount of hemoglobin

Answer 1

Normochromic cell

Question 2

Refers to erythrocytes where the central light area is larger and paler than the normal which MCH and MCHC are decreased, it is also often associated with microcytosis

Answer 2

Hypochromic cell

Question 3

Red cells which have an increased hemoglobin content and wherein the central light area is smaller than the normal

Answer 3

Hyperchromic cell

Question 4

This condition wherein the red cell are stained w/ various shades of blue w/ tinges of pink due to affinity of hb to acid and affinity of RNA to basic dye, it also indicates reticulocytosis

Answer 4

POLYCHROMATOPHILIA/POLYCHROMASIA/DIFFUSE BASOPHILIA

Question 5

Condition where the red cell appear as pale, it has two possible causes which is dec. Hb concentration and abnormal thinness of the cells

IDA, SIDEROBLASTIC ANEMIA, THALASSEMIA

Answer 5

Hypochromasia

Question 6

Condition where red cell are deeply stained into abnormal thickness of cell due to macrocytosis sherocytosis and megaloblastic anemia

Answer 6

Hyperchromasia

Question 7

Condition where the red cells vary in both macrocytes and microcytes coexist in the same smear

Answer 7

Anisocytosis

Question 8

Normal size in diameter of redcells

Answer 8

6-8um in diameter

Question 9

Cells larger than normal greater than 8um in size round in shape mcv>100 fl

Answer 9

Macrocyte

Question 10

What disease macrocyte detect?

Answer 10

Abnormal nuclear maturation
But normal cytoplasmic maturation

Question 11

Associated disease in macrocyte

Answer 11

Non megaloblastic anemia
Myelodysplastic syndrome
Chronic liver disease
Bm failure
Reticulocytosis

Question 12

Cells which is less than 6um in size

Answer 12

Microcytosis

Question 13

Microcytosis is found in

Answer 13

IDA
THALASSEMIA
HEMOLYTIC ANEMIAHB E DISEASE
INFLAMMATION
CHRONIC POST HEMORRHAGIC ANEMIA
SIDEROBLASTIC ANEMIA

Question 14

A large oval shaped red cell which is 9-12 um

Answer 14

Megalocyte

Question 15

Megalocyte is found in

Answer 15

Megaloblastic anemia like pernicious anemia
Anemia
VIT B12 DEFICIENCY
D. LATUM INFECTION

Question 16

Redcells exhibit variation in shape

Answer 16

Poikilocytosis

Question 17

A normal cell with a biconcave diskshape with increased surface of volume surface

Answer 17

Discocyte

Question 18

It is a small dense rbc with a few irregularly spaced projection of varying length

Answer 18

Acanthocyte(spur cell)

Question 19

Acanthocyte can detect

Answer 19

Abnormal membrane defect cause by an increase shingomyelin and dec cholesterol and phospholipid

Question 20

Associated disease in acanthocyte

Answer 20

Neuroacanthocytosis
Severe liver disease

Question 21

Cell membrane is folded

Answer 21

Biscuit cell (folded RBC)

Question 22

Cell assumes a pocket book roll appearance or biscuit shape, it also associated with HBSC & HBCC DISEASE

Answer 22

Biscuit cell

Question 23

Abnormal lipid content of the membrane which cell irregularly spaced blunt processes resemble crenated RBC

Answer 23

Burr cell

Question 24

Associated disease with burr cell

Answer 24

Uremia
MAHA
LIVER DISEASE
DIC
TIP
PK

Question 25

It can detect g6p def resulting to accumulation of Heinz bodies, cell with eccentric vacuoles due to the plucked out of heinz bodies

Answer 25

Blister cell(bite cell)

Question 26

Atp deficiency due to prolonged storage of anticoagulated blood Pathologically due to abnormal lipid content of the membrane

Answer 26

Crenated cells/echinocytes/Sea-urchin cells

Question 27

Associated disease in crenated cells

Answer 27

Seen in uremia bleeding Ulcers Gastric carcinoma Hepatitis Cirrhosis

Question 28

It is a def. In cholesterol phospholipid in the membrane def in lecithin cholesterol acyl transferase(LCAT) Cell with central area of hb surrounded by colorless area and a peripheral ring

Answer 28

Codocytes/targetcell/bull's eye cell/Mexican hat

Question 29

Disease associated with codocytes

Answer 29

THALASSEMIA LIVER DISEASE HEMOLYTIC ANEMIA HEMOGLOBIN SS LCAT DEF

Question 30

Abnormal maturation squeezing and fragmentation during splenic passage where cell appear in the shape of a teardrop or pear with a single short or long protrusion

Answer 30

Teardrop cell (Dacrocyte)

Question 31

Associated disease with teardrop cell

Answer 31

HA, MA, MMM

Question 32

A membrane due to defective spectrin def in band protein 4.1 Hb appear to be concentrated at the two ends of the cell leaving a nirmal central area of pallor, and life span is shortened

Answer 32

Elliptocytes/ovalocytes

Question 33

Elliptocytes/ovalocytes is usually found in

Answer 33

megaloblastic anemia Hypochromic anemia Hederitary ovalocytosis

Question 34

Small round dense cell w/c lacks the central palor area usually microcytic and sphere shaped and primary detect spectrin def, secondary defective interaction of spectrin w/ other skeletal protein

Answer 34

Spherocyte

Question 35

Associated disease in spherocyte

Answer 35

HS CHRONIC LYMPHOCYTE LEUKEMIA IMMUNE HEMOLYTIC ANEMIA DUE TO ABO INCOMPATIBILITY EXTENSIVE BURN HEREDITARY SPHEROCYTOSIS

Question 36

Is a crescent shape due to abnormal aggregation of hbS which gives a tendency for the cell to assume sickle shape

Answer 36

Sickle cell/drepanocytes

Question 37

Cell fragmentation due to the trauma caused by physical and mechanical agents, it is irregularly contracted cell, fragmented cell

Answer 37

Schistocytes

Question 38

It is characterized by an elongated or sot like area of central pallor It is caused by osmtic changes due to cation imbalance (Na, k)

Answer 38

Stomato cyte/mouth cells