Reactions

Question 1

Aldol Reaction

Answer 1

two carbonyls to a,b-unsaturated ketone

Question 2

Pinacol Coupling

Answer 2

2 carbonyls reacts with Mg to couple, forming diol, rearranges to ketone

Question 3

Enolate Alkylation

Answer 3

enolate reacts with electrophile by sn2

Question 4

alcohol dehydration

Answer 4

alcohol to alkene, generally most stable with shifts

Question 5

barton deoxygenation

Answer 5

alcohol to alkane via radicals

Question 6

Radical Dehalogenation

Answer 6

alkyl halide to alkane via radicals

Question 7

Clemmenson Reduction

Answer 7

carbonyl to methylene with Zn(Hg) and H+

Question 8

Wollf-Kishner

Answer 8

Carbonyl to methylene under base with H2NNH2

Question 9

Michael Reaction

Answer 9

enolate reacts with a,b-unsaturated carbonyl to form 1,5 carbonyl

Question 10

Ozonolysis

Answer 10

split alkene into symmetrical carbonyls

Question 11

Stetter Reaction

Answer 11

1,4 addition of aldehyde to a,b-unsaturated carbonyl wiht NEt3

Question 12

O-allylation

Answer 12

oxygen anion acts as nucleophile in sn2

Question 13

Friedel Crafts Alkylation

Answer 13

benzene reacts with alkylhalide by lewis acid activation

Question 14

Friedel Crafts Acylation

Answer 14

benzene reacts with acid chloride by lewis acid activation

Question 15

Ether Formation

Answer 15

alcohol reacts with alkyl halide in presence of base

Question 16

acetal formation

Answer 16

carbonyl reacts with alcohol (once to hemi, twice to acetal)

Question 17

alkene metathesis

Answer 17

exchange substituents of two alkenes by catalysis

Question 18

Wittig Olefination

Answer 18

Carbonyl reacts with phosphonium ylide to form alkene

Question 19

Epoxidation

Answer 19

alkene reacts with m-CPBA stereoselectively

Question 20

Alkene addition

Answer 20

add electrophilie/nucleophile to alkene

Question 21

robinson annulation

Answer 21

michael addition followed by intramolecular aldol to form a,b unsaturated carbonyl cyclohexene

Question 22

Mozingo Reduction

Answer 22

carbonyl to methylene via thioketal

Question 23

Simmons Smith

Answer 23

cyclopropanation of alkene with Zn(Cu) and CH2I2

Question 24

Diekmann Reaction

Answer 24

Intramolecular claissen

Question 25

Alkyne Alkylation

Answer 25

Deprotonate alkyne to act as nucleophile in Sn2

Question 26

Gem diol

Answer 26

react carbonyl with water and vice versa

Question 27

Amine synthesis

Answer 27

reduction of amides, reduction of nitriles, hydrogenation of nitros, reduction of azides, reaction with alkyl halides, reduction of imines/enamines

Question 28

Carboxylic Acid Synth

Answer 28

oxidation of alcohols/aldehydes, gridnard addition to CO2

Question 29

Fischer Esterification

Answer 29

carboxylic acid with alcohol

Question 30

acid chloride synth

Answer 30

carboxylic acid with SOCl2

Question 31

amide synth

Answer 31

acid chloride and amine (Sn2)

Question 32

anhydride synth

Answer 32

acid chloride and carboxylate anion

Question 33

Villsmer Haack Formylation

Answer 33

Pyridine reacts with POCl3 and water to add aldehyde

Question 34

Organocopper reactions

Answer 34

reacts with alkyl halides, acyl halides, epoxides and a,b-unsaturated carbonyls to add alkyl group

Question 35

Weinreb amides

Answer 35

react with grignards to form ketones

Question 36

Wadsworth Emmons Olefination

Answer 36

Forms trans alkenes from phosphonium substrate

Question 37

Nitrile/azide synth

Answer 37

react alkyl halide with NaCN/N3

Question 38

Imine/enamine Synth

Answer 38

react carbonyl with amine

Question 39

Dihydroxylation

Answer 39

react alkene with OsO4 to add diol

Question 40

Hydrolysis of nitriles

Answer 40

goes to carboxylic acids

Question 41

Decarboxylation

Answer 41

eliminates CO2 from dicarbonyl

Question 42

Mannich Reaction

Answer 42

carbonyl reacts with amine and formaldehyde to form b-amino carbonyl

Question 43

Wohl Zeigler Reaction

Answer 43

adds bromine adjacent alkene via NBS radical

Question 44

Fischer Indole Synthesis

Answer 44

reaction of C6H6NHNH2 and aldehyde ketone to form indole

Question 45

Claisen Johnson Rearrangement

Answer 45

allylic alcohol reacts with trialkyl ether to produce a 1,6 unsaturated carbonyl ester.

Question 46

Eltrophilic aromatic substitution

Answer 46

benzene reacts with activated electrophiles such as halides, nitric acid, sulfonic acid, alkyls, acyls

Question 47

allylic oxidation

Answer 47

subbed alkene reacts with SeO2 to form allylic alcohol