Readings Flashcards
(14 cards)
What is the evidence regarding GLP 1 agonists and sarcopenia or frailty?
There is no evidence to support sarcopenia or frailty. The reduction in FFM/SMM is less than fat mass and improves overall composition
What happends with repeated cycles of weight loss/gain?
Fat mass is regained and not FFM which results in overall metabolic risks due to adiposity.
How much weight regain occurs 1 year after ceasing GLP 1 agonists?
One half to two thirds
What evidence is there for fish oil in CVD?
Low quality eveidence shows it may slightly reduce CVD event risk, CHD mortality and arrhythmia but moderate-high quality shows little to no evidence.
Evidence for vitamin D and calcium in premenopausal women?
Does not support the isolated or combined use of calcium and vitamin
D supplementation in healthy premenopausal women as a public health intervention to improve BMD
in the total hip or lumbar spine.
How does fish oil work in theory?
lowering the blood pressure; altering the lipid profile, especially reduced serum triglyceride concentration;
modulating arterial lipoprotein lipase levels; reducing thrombotic tendency; producing anti-inflammatory
effects and anti-arrhythmic effects; improving vascular endothelial function and insulin sensitivity; and
increasing plaque stability and paraoxonase levels
What is there evidence for regarding vaping?
Substantial evidence for dependance in non-smokers
Limited evidence of higher abuse liability then NRT
Moderate evidence that vaping causes increased HR, bp, and arterial stiffness immediately after use in smokers
Conclusive evidence:
- it casues respiratory disease
- burns and injuries that may result in death
- poisoning and nicotine toxicity
- airborne particulate indoors, fires and environmental waste.
- can lead to seizures
Moderate evidence of less severe AE (cough, dizziness, headache).
What does evidence show sick day management needs?
Requires patient education on self-management strategies, communication with health care
providers, and tools to translate the guidance into practice.
What interventions are effective for shingles PHN?
regular anti-neuropathic drug administration accompanied by interventional therapies at an early stage is the best choice to treat patients with PHN. Appropriate combinations
of d/t interventions show improved pain relief
What is the evidence for triple therapy?
Reduces FEV1 trough levels, severe exacerbations, no effect on mortality or AE but increase pneumonia events.
Which agents have high evidence quality for neuropathic pain?
SNRRs (duloxetine), gabapentin and pregabalin, amitritpyline has moderate evidence.
Which agent for neuropathic pain has high NNH?
Gabapentin
Order of NNT for neuropathic pain?
Amitriptyline (moderate quality), duloxetine, gabapentin and pregabalin are equal.
Effectiveness of NRT, varenicline and buproprion?
Buproprion and single NRT is less effective than combined NRT and varenicline.
