Receptors And Neuropharmacology Flashcards
(17 cards)
What variety of animal is thought to have the earliest developed nervous system
Cnidarians
Give 2 differences between cniderian nervous systems and ours
In cnidarians there is no obvious organisation or nerve cells and they can communicate in both directions
What are 2 primary model systems
- The fruit fly drosophila melanogastor
- C. Elegans
What are disadvantages of studying eukaryotic cells
They are harder to manipulate and maintain
What are the 4 main criteria for something to be a neurotransmitter
- Synthesised in and enzymes for it must be in the neuron
- It must be released to elicit responses from the postsynaptic neuron
- Must have a mechanism for removal
- It must mimic an endogenously released neurotransmitter
What makes noradrenalines synthesis unusual
It is synthesised in the vesicle
What is the proper name for serotonin
5-HT
What is the difference between ion channels and ion transporters
Ion transporters require energy
What are nicotinic acetyl choline receptors permeable too
Cations only
What do general and local anesthetics target
They target the nervous system preventing signals
What do muscle relaxants target
Nicotinic acetylcholine receptors at neuromuscular junctions
What makes safe insecticides safe
They have good selectivity for their target protein but are relatively non-toxic to humans
Which neurotransmitter/s do not have a reuptake mechanism
Acetylcholine as it must be broken down then reuptaken
Which neurotransmitters can activate both intrepid and metabotropic receptors
Acetylcholine and glutamate
How do voltage gated ion channels sense changes in membrane potential
A domain with a high density of positively charged amino acids
How many neurons are within the nematode C. Elegans
302
What was the shaker mutation involved in the discovery of
Voltage gated K+ channels
