Red Blood Cells

Question 1

RBC Maturation Series

Answer 1

Pronormoblast/Rubriblast 
Basophilic Normoblast/Prorubricye
Polychromatophilic Normoblast/Rubricyte
Orthochromic Normoblast/Metarubricyte 
Polychromatophilic Erythrocyte/Reticulocyte
Erythrocyte

Question 2

Poikilocytosis

Answer 2

General variation in shape of the RBC

Question 3

Acanthocytes

Answer 3

Spur cells

Have a few projections on their membrane (wavy to spiky edges)

Question 4

Codocytes

Answer 4

Target cells

Have ring of pallor in them

Question 5

Hemoglobin Pudding

Answer 5

There is a lot of weirdness with the central pallor

Question 6

Dacryocytes

Answer 6

Tear drop cells

Question 7

Degmacytes

Answer 7

Bite cells

Caused by macrophages in the spleen taking bites out of the RBC

Question 8

Drepanocytes

Answer 8

Sickle cells

Caused by the polymerization of Hgb S

Question 9

Echinocytes

Answer 9

Hedgehog cells, burr cells

Have lots of little spikies

Question 10

Keratocyte

Answer 10

Horn or helmet cells

Caused by fragmentation of RBCs

Question 11

Knizocyte

Answer 11

Pinch cells

Band of Hgb across the central pallor

Question 12

Ovalocyte/Elliptocyte

Answer 12

Oval to rod-shaped RBC

Question 13

Pyknocyte

Answer 13

Blister cell
Central pallor is one half, other half is full of Hgb
Black and white cookie

Question 14

Schistocyte

Answer 14

Small pieces of RBC

Caused by mechanical destruction of RBC

Question 15

Schistocyte

Answer 15

Small pieces of RBC

Caused by mechanical destruction of RBC

Question 16

Spherocyte

Answer 16

Spherical, often darker colored, edged look taut
Can be macro or micro
Caused by mutations in the structural proteins of the RBC membrane

Question 17

Stomatocyte

Answer 17

Coin slit central pallor

Question 18

Anisocytosis

Answer 18

General variation in RBC size

Measured by RBW

Question 19

Dimorphism

Answer 19

Two distinct RBC populations are present

Question 20

Microcyte

Answer 20

RBC with a diameter less than 7 um

MCV less than 80

Question 21

Macrocyte

Answer 21

RBC with a diameter greater than 8 um

MCV greater than 100

Question 22

Polychromasia

Answer 22

Darker red/purple cells

Indicates an increased number of immature RBCs

Question 23

Hypochromia

Answer 23

Larger area of central pallor

Caused by insufficient Hgb

Question 24

Agglutination

Answer 24

Caused by blood clotting or cold agglutinins

Question 25

Rouleaux

Answer 25

When more than 5 RBCs are stacked in a row | Caused by high protein levels

Question 26

Basophilic Stippling

Answer 26

RNA seen as spots in the cell | Seen with Wrights stain

Question 27

Barr Bodies

Answer 27

Inactivated X chromosome

Question 28

Cabot Ring

Answer 28

Figure 8 of leftover microtubules from the mitotic spindle | Seen with Wrights stain

Question 29

Dyserythropoiesis

Answer 29

General creation of poor RBCs

Question 30

Heinz Bodies

Answer 30

Precipitated Hgb | Only seen with supravital stain

Question 31

Hemoglobin C

Answer 31

Rod-shaped crystal that makes the RBC rod-shaped | Seen with Wrights stain

Question 32

Hemoglobin H

Answer 32

Golf-ball like appearance Caused by Hgb beta-chain tetramers Seen with supravital stain

Question 33

Hemoglobin SC

Answer 33

Bird in flight | Seen with Wrights stain

Question 34

Howell-Jolley Bodies

Answer 34

Round body of DNA, only 1 or 2 per cell | Seen with Wrights stain

Question 35

Iron/Sideroblasts

Answer 35

Nucleated RBCs that contain iron granules Ringed sideroblasts have half of the nucleus surrounded Seen with Prussian blue stain

Question 36

Malaria

Answer 36

Micro-organism in the RBC | Seen with Wrights stain

Question 37

Pappenheimer Bodies

Answer 37

Clusters of iron granules | Seen with Wrights or Prussian blue stain

Question 38

Reticulum

Answer 38

RNA seen in the cell | Seen with supravital stain