Red Book - Pregnancy

Question 1

What is recommended for preconception supplementation?

Answer 1

1. Folate - 0.5mg/day (5mg if high risk) 1 month before conception until second trimester
2. Iodine - 150μg/day until no longer breastfeeding

Question 2

Other than supplementation, what 6 preconception preventive interventions are recommended?

Answer 2

1. Nutritional assessment and BMI optimisation
2. Check oral cavity and dentition
3. Smoking cessation
4. Avoid alcohol and illicit drugs
5. Aim for pregnancy intervals from 18-59 months
6. Optimise chronic disease and avoid teratogenic medications

Question 3

What 4 conditions should be considered for preconception or antenatal genetic testing?

Answer 3

1. Cystic fibrosis
2. Fragile X syndrome
3. Haemoglobinopathies and thalassaemias
4. Down Syndrome

Question 4

What is included in the first trimester Down Syndrome screening?

Answer 4

bHCG, pregnancy-associated plasma protein-A (PAPP-A) at 10-12/40
AND
nuchal translucency US at 11+3-13+6/40

OR NIPT from 10/40

Question 5

What is included in second trimester Down Syndrome screening?

Answer 5

bHCG, unconjugated oestriol, alpha-fetoprotein (AFP) and inhibin A, ideally at 15-17/40