Red Book Stuff Flashcards

1
Q

What are THREE vaccines recommended for adults > 65 years?

A
  1. Influenza vaccine (annually)
  2. Pneumococcal vaccine (single dose, opportunistically)
  3. Herpes zoster virus vaccine (single dose, > 60 years)
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2
Q

What vaccines are recommended prior to pregnancy (if not already immune / up to date)?

A
  1. diphtheria, tetanus, pertussis (DTP)
  2. measles, mumps, rubella (MMR)
  3. varicella
  4. hepatitis B
  5. influenza

N.B. if a woman has received a live vaccine (measles, mumps, rubella, varicella) she is to be advised NOT to fall pregnant within the next 28 days.

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3
Q
What vaccines are available under the National Immunisation Schedule (NIS) for the following age groups: 
✔️ birth
✔️ 2 months
✔️ 4 months
✔️ 6 months
✔️ 12 months
✔️ 18 months
A

BIRTH
✔️ hepatitis B

2 MONTHS
✔️ DTPa - HBV - IPV / Hib
✔️ Pneumococcal
✔️ Rotavirus

4 MONTHS
✔️ DTPa - HBV - IPV / Hib
✔️ Pneumococcal
✔️ Rotavirus

6 MONTHS
✔️ DTPa - HBV - IPV / Hib
✔️ Pneumococcal
✔️ Rotavirus

12 MONTHS
✔️ measles, mumps, rubella
✔️ Hib - MenC
✔️ Pneumococcal (at risk groups only)

18 MONTHS
✔️ measles, mumps, rubella, varicella
✔️ DTPa

4 YEARS
✔️ MMR or MMRV (if missed)
✔️ DTPa - IPV
✔️ Pneumococcal (at risk groups only)

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4
Q

What vaccines are appropriate for all healthcare workers?

A

✔️ hepatitis
✔️ MMRV
✔️ DTPa
✔️ influenza

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5
Q

What are the screening guidelines for colorectal cancer in an individual with NORMAL RISK?

A

For normal risk individuals, iFOBT should be conducted every 2 years from the age of 50 to 74 years with repeated negative results.

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6
Q

What factors constitute MODERATE RISK for colorectal cancer? How should these people be screened?

A

CRITERIA:
✔️ one family member diagnosed with CRC < 55 years of age
✔️ two first degree relatives or one first degree + one second degree (same side of the family) diagnosed with CRC at any age

SCREENING: colonoscopy every five years from 50 years of age or 10 years prior to age of diagnosis

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7
Q

What factors constitute HIGH RISK for colorectal cancer? How should these people be screened?

A

CRITIERA:
✔️ three first degree or three second degree relatives with CRC (at least one < 55 years)
✔️ three or more first degree relatives with CRC at any age
✔️ family history of Lynch Syndrome

SCREENING: iFOBT every two years from 35 to 44 years and then colonoscopy every five years from 45 to 74 years

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8
Q

What are the screening guidelines for breast cancer in an individual with NORMAL RISK?

A

For normal risk individuals, mammogram should be conducted every 2 years from 50 to 74 years with repeated negative results.

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9
Q

What factors constitute MODERATE RISK for breast cancer? How should these people be screened?

A

CRITERIA:
✔️ one or more family member diagnosed < 50 years
✔️ two first degree relatives (on the same side of the family) diagnosed at any age
✔️ two second degree relatives diagnosed at any age (however, one must be < 50 years)

SCREENING: consider mammogram every year from 40 years of age (minimum screening recommendations is mammogram every two years from 50 years)

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10
Q

What factors constitute HIGH RISK for breast cancer? How should these people be screened?

A

CRITERIA:
✔️ first degree relative diagnosed < 40 years of age
✔️ breast + ovarian cancer in the same women
✔️ bilateral breast cancer
✔️ male breast cancer

SCREENING: referral to a breast screening program for individualised surveillance

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11
Q

What are the screening guidelines for cervical cancer in an individual with NORMAL RISK?

A

All women should be screened for cervical cancer via the CST from 25 years of age, or TWO years after their first experience of sexual intercourse, whichever is later. Screening should take place every 5 years.

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12
Q

Describe the current recommendations / guidelines in place for screening of prostate cancer.

A
  • Currently in Australia, prostate cancer is not routinely screened for via the DRE or PSA.
  • Risk naturally increases with increasing age and a family history.
  • Due to slow progression of the disease, any man > 75 years or with a life expectancy < 10 years at the time of diagnosis, is more likely to die “with” prostate cancer than “from” prostate cancer.
  • Any requests from the patient should be acknowledge and met where possible, however, it is also important to council the patient on the limitations of the PSA.
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13
Q

Describe the current recommendations / guidelines in place for screening of skin cancer.

A
  • All Australians should be educated about sun safety / protection.
  • Self-skin examinations should be encouraged every three months, particularly for individuals at a “high risk.”
  • Clinical assessment of high risk individuals may be necessary every six months.
  • Factors that influence risk stratification include:
    ✔️ age
    ✔️ gender
    ✔️ family history
    ✔️ ethnicity / skin type
    ✔️ skin responsiveness to sun exposure / burn
    ✔️ evidence of keratinic skin
    ✔️ number of atypical melanocytic naevi
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14
Q

Define OSTEOPOROSIS.

A

Osteoporosis is reduced bone density, micro-vasculature fractures within the bone and a T score of < -2.5

Note that in a patient who has experienced a fragility fracture, a T Score of < -2.5 is NOT required for a diagnosis.

T score < -1.5 is suggestive of osteopenia.

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15
Q

Risk factors for osteoporosis?

A
✔️ increasing age
✔️ female gender
✔️ post-menopausal
✔️ low BMI
✔️ physical inactivity / immobility
✔️ inadequate Vitamin D or Ca ++ intake
✔️ malnutrition
✔️ smoking
✔️ excessive alcohol consumption
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16
Q

Define secondary osteoporosis. Identify some causes.

A
Secondary osteoporosis is reduced bone mineral density that occurs as a result of a primary medical condition. This includes: 
✔️ Cushing's Disease / Syndrome
✔️ hyperthyroidism
✔️ hyperparathyroidism
✔️ anorexia nervosa
✔️ malabsorption (e.g. Coeliac Disease)
✔️ inflammatory conditions (e.g. RA)
✔️ drugs and medications (e.g. methotrexate, corticosteroids)
✔️ chronic liver or kidney disease
17
Q

What are the current screening recommendations / guidelines in Australia for osteoporosis?

A

Women should be screened from 45 years of age.
Men should be screen from 50 years of age.

The bone mineral density test (DXA) test is appropriate for screening. Measurements should be taken from at least two areas (e.g. pelvic, femur) every two years.

18
Q

Define METABOLIC SYNDROME.

A

Metabolic syndrome requires THREE of the following five criteria:

  1. triglycerides > / = to 1.7 mmol / L
  2. glucose resistance > 5.5 mmol / L (fasting)
  3. HDL-C to total-C ratio < / = to 1.0 mmol / L (males) or < / = 1.3 mmol / L (females)
  4. waist circumference > / = 102 cm (males) or > / = 88 cm (females)
  5. blood pressure > 130 mmHg SBP or > 80 mmHg DBP

Metabolic syndrome is characterised by a cluster of features that all share the same underlying pathophysiology of insulin resistance, and significantly increase an individuals’ risk of both diabetes mellitus and cardiovascular disease.

19
Q

Outline management of METABOLIC SYNDROME.

A

Metabolic syndrome depends on both lifestyle (non-pharmacological) and pharmacological interventions:
✔️ weight loss of 5 to 10%
✔️ caloric deficit of ~600 kCal per day
✔️ 30 mins of moderate physical activity per day
✔️ smoking cessation
✔️ alcohol reduction to within appropriate limits
✔️ pharmacological management of hypertension, dyslipidemia and insulin resistance (if appropriate)
✔️ cessation of drugs contributing to hyperglycaemia / insulin resistance

20
Q

Define ABSOLUTE CARDIOVASCULAR RISK.

A

Absolute cardiovascular risk assessment is a tool used to stratify the risk that an individual will experience an adverse cardiovascular event (e.g. stroke, MI) within the next FIVE years.

It should be calculated every TWO years from the age of 45 years (non-ATSI people) or from 35 years (ATSI people).

21
Q

Identify HIGH RISK populations in regard to the absolute cardiovascular risk (i.e. people who do not require an assessment).

A

✔️ diabetes mellitus > 60 years of age
✔️ diabetes mellitus with microalbuminemia
✔️ ATSI people > 74 years
✔️ moderate or severe CKD
✔️ familial hypercholesterolemia
✔️ triglycerides >7.5 mmol / L
✔️ SBP > / = 180 mmHg or DBP > / = 110mmHg
✔️ previous adverse cardiovascular event (e.g. MI, stroke)

22
Q

Outline the components of the ABSOLUTE CARDIOVASCULAR RISK assessment.

A

NON-MODIFIABLE RISK FACTORS
✔️ age
✔️ gender
✔️ ATSI status

MODIFIABLE RISK FACTORS
✔️ smoking
✔️ diabetes mellitus
✔️ systolic blood pressure
✔️ left ventricular hypertrophy on ECG
✔️ HDL-C to total-C ratio
23
Q

Outline interpretation of the ACR.

A

Low risk: <10%
Moderate risk: 10 to 15%
High risk: >15%

24
Q
Blood pressure values / cutoffs for: 
✔️ normal
✔️ high normal
✔️ Grade 1 HTN
✔️ Grade 2 HTN
✔️ Grade 3 HTN
A

Normal: SBP < 120 mmHg DBP < 80 mmHg

High Normal: SBP 120 - 139 mmHg DBP 80 - 89 mmHg

Grade I HTN: SBP 140 - 159 mmHg DBP 90 - 99 mmHg

Grade II HTN: SBP 160 - 179 mmHg DBP 100 - 109 mmHg

Grade III HTN: SBP > 180 mmHg DBP > 110 mmHg

25
Q

What are the current screening guidelines for blood pressure?

A

BP should be monitored every TWO years from 18 years of age. From 45 years of age, BP should be considered in the context of ABSOLUTE CARDIOVASCULAR RISK (>35 years for ATSI people).

26
Q

Describe the management options + screening guidelines for blood pressure in LOW RISK individuals.

A

RISK CATEGORY: < 10% ACR

MANAGEMENT OPTIONS:
✔️ lifestyle interventions / counselling
✔️ commence pharmacotherapy if BP > 160 / 110 mmHg
✔️ if SBP between 140 - 159 mmHg, review after 2 months of lifestyle interventions

SCREENING GUIDELINES:
✔️ review BP every TWO years

27
Q

Describe the management options + screening guidelines for blood pressure in MODERATE RISK individuals.

A

RISK CATEGORY: 10 - 15% ACR

MANAGEMENT OPTIONS:
✔️ intensive lifestyle advice / counselling
✔️ commence pharmacotherapy if BP > 160 / 110 mmHg
✔️ consider pharmacotherapy if SBP between 140 - 159 mmHg or DBP between 100 - 109 mmHg
✔️ review in six months if SBP between 130 - 130 mmHg or DBP between 90 - 99 mmHg

SCREENING GUIDELINES:
✔️ review BP every 6 to 12 months

28
Q

Describe the management options + screening guidelines for blood pressure in HIGH RISK individuals.

A

RISK CATEGORY: > 15% ACR

MANAGEMENT OPTIONS:
✔️ commence on pharmacotherapy immediately
✔️ +/- statin / lipid therapy

SCREENING GUIDELINES:
✔️ review BP every 6 to 12 weeks

29
Q

What are the current screening guidelines for lipids?

A

Lipids should be screened for every FIVE years in low risk individuals.

From 45 years of age, this should occur in the context of ABSOLUTE CARDIOVASCULAR RISK (>35 years for ATSI people).

30
Q
What are the target blood pressures for: 
✔️ no co-morbidities
✔️ diabetes mellitus
✔️ kidney disease
✔️ proteinuria > 1g / day
A

NO COMORBIDITIES: < 140 / 90 mmHg

DIABETES AND CKD (end-organ complications): < 130 / 80 mmHg

PROTEINURIA > 1 g per day: < 125 / 75 mmHg

31
Q

Describe the management options + screening guidelines for lipid monitoring in LOW RISK individuals.

A

RISK CATEGORY: < 10% ACR

MANAGEMENT OPTIONS:
✔️ offer lifestyle advice

SCREENING GUIDELINES:
✔️ every 5 years

32
Q

Describe the management options + screening guidelines for lipid monitoring in MODERATE RISK individuals.

A

RISK CATEGORY: 10 - 15% ACR

MANGEMENT OPTIONS:
✔️ offer intensive lifestyle advice
✔️ consider pharmacotherapy if family history of premature CVD, ATSI origin or South East Asian background

SCREENING GUIDLINES:
✔️ every five years

33
Q

Describe the management options + screening guidelines for lipid monitoring in HIGH RISK individuals.

A

RISK CATEGORY: > 15% ACR

MANAGEMENT OPTIONS:
✔️ commence pharmacotherapy +/- antihypertensive management

SCREENING GUIDELINES:
✔️ measure lipids every 12 months

34
Q

What are some common side effects of statin therapy?

A
✔️ muscle aches and pains
✔️ muscle cramps
✔️ myopathy
✔️ hepatotoxicity 
✔️ rhabdomyolysis
✔️ GI side effects (eg. nausea, vomiting, diarrhoea)
35
Q

What are the current screening guidelines for DIABETES MELLITUS?

A

Adults should be screened every THREE YEARS from the age of 40 years (from 18 years of age in ATSI people) via the AUSDRISK screening tool.

36
Q

What factors place an individual at HIGH RISK for diabetes? What are the current screening recommendations for these people?

A
HIGH RISK FACTORS: 
✔️ adult > 40 years of age who is overweight or obese
✔️ first degree relative with diabetes
✔️ women with PCOS
✔️ women with gestational diabetes
✔️ patients on antipsychotic medications
✔️ any patient with a history of previous stroke or MI
✔️ AUSDRISK > 12

In these patients, HbA1c or FBG should be measured every THREE YEARS.

37
Q

Outline what should be checked according to the DIABETES CYCLE OF CARE at the following intervals:
✔️ 6-monthly
✔️ 12-monthly
✔️ 24-monthly

A

EVERY 6 MONTHS
✔️ height, weight and BMI
✔️ blood pressure
✔️ check feet for complications

EVERY 12 MONTHS
✔️ physical activity, smoking, nutrition, alcohol etc
✔️ HbA1c, FBG and RBG
✔️ HDL-C, LDL-C, total-C and triglycerides
✔️ micro-albuminemia

EVERY 24 MONTHS
✔️ comprehensive eye examination

38
Q
What are the targets for the following parameters in diabetic patients: 
✔️ blood pressure
✔️ lipids
✔️ HbA1c
✔️ glucose levels
✔️ urine albumin excretion
A

BLOOD PRESSURE: < 130 / 80 mmHg (or < 125 / 75 mmHg if proteinuria > 1g per day)

LIPIDS: 
✔️ total-C < 4 mmol / L
✔️ HDL-C > 1 mmol / L
✔️ LDL-C < 2.5 mmol / L
✔️ triglycerides < 2.0 mmol / L

HbA1c: < 7.0% (53 mmol / L)

Glucose Levels:
✔️ fasting glucose 5-10 mmol / L
✔️ post-prandial glucose 4 - 7 mmol / L

Urine Albumin Excretion:
✔️ females < 3.5 mg / mmol
✔️ males < 2.5 mg / mmol