Red Lesions Flashcards
(33 cards)
What is melanin?
Melanin is a brown-black pigment produced by melanocytes and can be deposited in non-melanocytes.
What is hemoglobin?
Hemoglobin is a red pigment found in red blood cells that turns bright red when it binds to oxygen and darker when it releases oxygen.
What causes changes in color of oral lesions?
Changes in color can be caused by deposition of exogenous pigmentation, increased blood vessel dilation, increased melanin pigmentation, increased keratinization, decreased keratinization, reduced epithelium thickness, alterations in blood vessel structure, molecular changes to hemoglobin, or adipose tissue deposits.
What are the endogenous molecular causes of color?
The endogenous molecular causes of color include melanin and hemoglobin.
What are the key points regarding red lesions?
Red lesions can range from non-specific to specific, benign to malignant. Key considerations include symptoms that disrupt daily functioning, recurrent or chronic lesions, blistering and bleeding lesions, and mixed lesions.
What is the mnemonic for identifying red flags in lesions?
The mnemonic is RED FLAGS: Rapid change, Extreme symptoms, Duration, Features, Location, Associated symptoms, Growth, Size.
What should you do when assessing red lesions?
You should see and describe the lesion, ask and listen to the patient’s history, spot RED FLAGS, document findings, and refer urgently if there is high suspicion for cancer or other serious conditions.
What are some differential diagnoses for oral lesions?
Differential diagnoses include desquamative gingivitis, oral lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, and erythroleukoplakia.
What is oral lichen planus?
Oral lichen planus is a chronic, T-cell mediated inflammatory condition with variable clinical presentations, associated with a risk of malignant transformation.
What is pemphigus vulgaris?
Pemphigus vulgaris is a life-threatening autoimmune bullous disease characterized by flaccid blisters and erosions of mucous membranes and/or skin.
What is mucous membrane pemphigoid?
Mucous membrane pemphigoid is a group of chronic autoimmune subepithelial blistering diseases predominantly affecting mucous membranes.
What are the clinical patterns of oral lichen planus?
The clinical patterns include reticular, plaque-like, erythematous, erosive/ulcerative, papular, and bullous.
What is desquamative gingivitis?
Desquamative gingivitis is characterized by raw, peeling gums with possible fluid-filled bumps and may be associated with conditions like oral lichen planus.
What is the significance of direct immunofluorescence in pemphigus vulgaris?
Direct immunofluorescence shows a ‘fish-scale’ pattern of IgG around the cells in the prickle cell layer.
What is the Oral Disease Severity Score (ODSS)?
The Oral Disease Severity Score is used to assess the severity of conditions like pemphigus vulgaris, mucous membrane pemphigoid, and oral lichen planus.
What are the guidelines on diagnosis and management of mucous membrane pemphigoid?
Guidelines initiated by the European Academy of Dermatology and Venereology.
J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1750-1764. doi: 10.1111/jdv.17397.
What is the significance of direct immunofluorescent staining in pemphigoid?
It shows a linear deposition of IgG at the basement membrane.
What are erythroplakia and erythroleukoplakia?
Erythroplakia is a premalignant lesion characterized by a red plaque, while erythroleukoplakia is a nonhomogeneous leukoplakia with red, velvety areas around a white plaque.
What is the malignant transformation rate for erythroplakia and erythroleukoplakia?
18-47% malignant transformation.
What are the major risk factors for erythroplakia and erythroleukoplakia?
Smoking, excessive alcohol consumption, personal or familial history of cancer, male gender, advanced age, history of cancer therapy, and prolonged immunosuppression.
What are the common sites involved in erythroplakic lesions?
Floor of the mouth, tongue, soft palate, and buccal mucosa.
What is the typical appearance of erythroplakic lesions?
Smooth or granular, velvety plaques with generally well-demarcated margins.
What is the biopsy result for erythroplakia and erythroleukoplakia?
Over 70–90% of erythroplakia lesions exhibit carcinoma in situ and invasive squamous cell carcinoma, while up to 50% in erythroleukoplakia.
What are the red flags for red lesions in the oral cavity?
Mixed lesions, current or historical tobacco use, persistence, no obvious cause for ulceration, presence of OPMDs, blood dyscrasias, past oncological history, B symptoms.