Red Lesions Flashcards

(33 cards)

1
Q

What is melanin?

A

Melanin is a brown-black pigment produced by melanocytes and can be deposited in non-melanocytes.

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2
Q

What is hemoglobin?

A

Hemoglobin is a red pigment found in red blood cells that turns bright red when it binds to oxygen and darker when it releases oxygen.

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3
Q

What causes changes in color of oral lesions?

A

Changes in color can be caused by deposition of exogenous pigmentation, increased blood vessel dilation, increased melanin pigmentation, increased keratinization, decreased keratinization, reduced epithelium thickness, alterations in blood vessel structure, molecular changes to hemoglobin, or adipose tissue deposits.

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4
Q

What are the endogenous molecular causes of color?

A

The endogenous molecular causes of color include melanin and hemoglobin.

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5
Q

What are the key points regarding red lesions?

A

Red lesions can range from non-specific to specific, benign to malignant. Key considerations include symptoms that disrupt daily functioning, recurrent or chronic lesions, blistering and bleeding lesions, and mixed lesions.

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6
Q

What is the mnemonic for identifying red flags in lesions?

A

The mnemonic is RED FLAGS: Rapid change, Extreme symptoms, Duration, Features, Location, Associated symptoms, Growth, Size.

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7
Q

What should you do when assessing red lesions?

A

You should see and describe the lesion, ask and listen to the patient’s history, spot RED FLAGS, document findings, and refer urgently if there is high suspicion for cancer or other serious conditions.

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8
Q

What are some differential diagnoses for oral lesions?

A

Differential diagnoses include desquamative gingivitis, oral lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, and erythroleukoplakia.

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9
Q

What is oral lichen planus?

A

Oral lichen planus is a chronic, T-cell mediated inflammatory condition with variable clinical presentations, associated with a risk of malignant transformation.

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10
Q

What is pemphigus vulgaris?

A

Pemphigus vulgaris is a life-threatening autoimmune bullous disease characterized by flaccid blisters and erosions of mucous membranes and/or skin.

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11
Q

What is mucous membrane pemphigoid?

A

Mucous membrane pemphigoid is a group of chronic autoimmune subepithelial blistering diseases predominantly affecting mucous membranes.

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12
Q

What are the clinical patterns of oral lichen planus?

A

The clinical patterns include reticular, plaque-like, erythematous, erosive/ulcerative, papular, and bullous.

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13
Q

What is desquamative gingivitis?

A

Desquamative gingivitis is characterized by raw, peeling gums with possible fluid-filled bumps and may be associated with conditions like oral lichen planus.

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14
Q

What is the significance of direct immunofluorescence in pemphigus vulgaris?

A

Direct immunofluorescence shows a ‘fish-scale’ pattern of IgG around the cells in the prickle cell layer.

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15
Q

What is the Oral Disease Severity Score (ODSS)?

A

The Oral Disease Severity Score is used to assess the severity of conditions like pemphigus vulgaris, mucous membrane pemphigoid, and oral lichen planus.

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16
Q

What are the guidelines on diagnosis and management of mucous membrane pemphigoid?

A

Guidelines initiated by the European Academy of Dermatology and Venereology.

J Eur Acad Dermatol Venereol. 2021 Sep;35(9):1750-1764. doi: 10.1111/jdv.17397.

17
Q

What is the significance of direct immunofluorescent staining in pemphigoid?

A

It shows a linear deposition of IgG at the basement membrane.

18
Q

What are erythroplakia and erythroleukoplakia?

A

Erythroplakia is a premalignant lesion characterized by a red plaque, while erythroleukoplakia is a nonhomogeneous leukoplakia with red, velvety areas around a white plaque.

19
Q

What is the malignant transformation rate for erythroplakia and erythroleukoplakia?

A

18-47% malignant transformation.

20
Q

What are the major risk factors for erythroplakia and erythroleukoplakia?

A

Smoking, excessive alcohol consumption, personal or familial history of cancer, male gender, advanced age, history of cancer therapy, and prolonged immunosuppression.

21
Q

What are the common sites involved in erythroplakic lesions?

A

Floor of the mouth, tongue, soft palate, and buccal mucosa.

22
Q

What is the typical appearance of erythroplakic lesions?

A

Smooth or granular, velvety plaques with generally well-demarcated margins.

23
Q

What is the biopsy result for erythroplakia and erythroleukoplakia?

A

Over 70–90% of erythroplakia lesions exhibit carcinoma in situ and invasive squamous cell carcinoma, while up to 50% in erythroleukoplakia.

24
Q

What are the red flags for red lesions in the oral cavity?

A

Mixed lesions, current or historical tobacco use, persistence, no obvious cause for ulceration, presence of OPMDs, blood dyscrasias, past oncological history, B symptoms.

25
What does the mnemonic WATCH OUT B stand for?
White & Red mix, Always a smoker, Takes forever to heal, Can't find a cause, History of bad stuff, Other health issues, Unexplained weight loss, Temperature spikes/sweats at night.
26
What are the general principles of management for oral lesions?
Do not perform dental treatment unless diagnosis is confirmed, refer immediately to Oral medicine, inform GMP of findings.
27
What are the goals of management for oral lesions?
Healing of lesions, preventing recurrence, preventing impact on quality of life, managing immunosuppression.
28
What should you do when you don’t know how to proceed?
Take a comprehensive history, ask patient concerns, understand normal anatomy, identify red flags, describe the lesion, and call oral medicine specialists.
29
What is the ISBAR handover?
A structured communication tool for handover in medical settings.
30
How do vesiculobullous conditions occur?
31
How do vesiculobullous conditions occur?
Vesiculobullous conditions are skin or mucous membrane (like the inside of your mouth) problems where blisters form. Think of your skin or the lining of your mouth as having layers, like sheets of paper stacked together. These conditions happen when something causes these layers to separate. When they separate, a space is created, and this space fills up with fluid, forming a blister. "Vesicle" just means a small blister, and "bulla" means a large one. What causes the layers to separate? There are a few main reasons: Immune System Mix-up (Autoimmune): Sometimes, the body's defense system gets confused and mistakenly attacks the "glue" or proteins that normally hold the skin/mucous membrane layers tightly together. When this "glue" is damaged, the layers come apart, and blisters form. (This is common in conditions like Pemphigus vulgaris or Mucous Membrane Pemphigoid). Genetic "Weak Spots": Some people are born with a genetic condition where the parts that hold the skin layers together are naturally weaker. This means blisters can form very easily, sometimes from just minor rubbing. (This is seen in conditions like Epidermolysis Bullosa). Infections: Certain viruses (like Herpesviruses – e.g., Herpes Simplex causing cold sores/genital herpes, or Varicella-Zoster virus causing chickenpox and shingles) or some bacteria can directly damage the skin cells or the connections between them, leading to blisters. Physical Damage: Things like severe burns (thermal blisters), intense friction (friction blisters), or exposure to certain chemicals can physically force the skin layers apart, causing blisters. So, in simple terms, vesiculobullous conditions occur when the layers of your skin or mucous membranes come apart, and the space fills with fluid, creating a blister. The reason for this separation can vary, from your own immune system acting up (like in Pemphigus or Pemphigoid) to genetic factors (like in Epidermolysis Bullosa), infections, or external damage.
32
Mnemonic for General Principles of Management: The "P.R.I.A." Approach To remember these general management principles, think P.R.I.A. P - PAUSE & PROTECT Pause non-essential dental treatment until a diagnosis is clear and a specialist advises (especially if something like Desquamative Gingivitis - DSG - is suspected). Protect the area from further irritation or inappropriate treatment. R - REFER URGENTLY Refer the patient immediately and with urgency to an Oral Medicine specialist. Discuss referral pathways (private or public). I - INFORM & INTEGRATE Inform the patient's General Medical Practitioner (GMP) of the findings and the referral. Integrate care between dental and medical professionals. A - AIMS OF MANAGEMENT Focus on clear Aims: Achieve healing of lesions and prevent recurrence. Avoid negative impacts on Quality of Life (QoL). Administer and manage immunosuppression effectively (if required) and prevent long-term treatment complications. This P.R.I.A. approach helps ensure that red oral lesions are handled carefully, specialist advice is sought quickly, everyone involved in the patient's care is informed, and the treatment goals are clear.
33
red lesion map
Okay, here's the concise checklist for assessing red oral lesions, now incorporating specific considerations for Immunobullous Conditions and Periodontal Disease: Concise Checklist: Red Oral Lesions Assessment 1. Initial Check: * [ ] Single Lesion? (Go to Section A) * [ ] Multiple Lesions? / Widespread Redness? (Go to Section B) A. SINGLE Red Lesion Pathway: Investigate Local Factors: [ ] Local irritation (denture, sharp tooth)? [ ] Trauma (biting, mints)? [ ] New oral products (toothpaste, mouthwash, gum)? If Suspected Local Cause: [ ] Advise patient to eliminate suspected cause. [ ] Re-evaluate in 2 weeks. [ ] If Resolved: Monitor. [ ] If Persistent: Proceed below. If NO Obvious Local Cause OR Persistent Lesion: Consider: [ ] Early Immunobullous sign? (Persistent erosion, history of blistering, even if not currently visible?) [ ] Localized Severe Periodontal Issue? (Focused on gums, deep pocket, bleeding, pus?) [ ] Other potentially serious causes (e.g., early neoplasia - look for induration, non-healing ulceration)? Action: Refer for biopsy and/or specialist assessment (Oral Medicine/Periodontist as appropriate). B. MULTIPLE Red Lesions / Widespread Redness Pathway: Note Lesion Locations & Characteristics. Consider the following possibilities: [ ] Immunobullous Condition? (e.g., Pemphigus Vulgaris, Mucous Membrane Pemphigoid) Clues: History of blisters (even if they rupture quickly leaving erosions/ulcers)? Desquamative gingivitis (peeling, raw, red gums)? Lesions on other body surfaces (skin, eyes, genitals)? Action: Refer URGENTLY to Oral Medicine for diagnosis (likely includes biopsy with immunofluorescence). [ ] Periodontal Disease / Severe Gingivitis / Desquamative Gingivitis? Clues: Redness primarily on gums? Swelling, bleeding on probing? Plaque/calculus? Bad breath? Known history of gum disease? (Note: Desquamative gingivitis can be a sign of immunobullous disease or lichen planus too). Action: Perform thorough periodontal assessment. Manage periodontal disease. If desquamative or severe/atypical, refer to Periodontist or Oral Medicine (especially if immunobullous or lichen planus suspected). [ ] Lichen Planus? Clues: Non-migratory red areas, often with white lacy streaks/patches (Wickham's striae)? Commonly on buccal mucosa, tongue, gums? Action: Refer for confirmatory biopsy (Oral Medicine). [ ] Oral Candidiasis (Thrush)? Clues: Multiple red areas, sometimes with removable white patches? Burning sensation? Risk factors (e.g., denture use, antibiotics, dry mouth, immunosuppression)? Sub-type: Median Rhomboid Glossitis: Red, smooth patch in midline of dorsal tongue, non-cyclical, isolated. Sub-type: Erythematous Candidiasis (Denture Stomatitis): Redness under a denture, especially if worn 24/7. Action: Assess further, confirm (e.g., smear if needed), consider antifungal treatment and address predisposing factors. [ ] Geographic Tongue? Clues: Lesions (red areas with whitish borders) primarily on the top/sides of the tongue? Lesions change location/pattern ("move around"), come and go? Action: Reassure (benign condition). Key Reminders (Apply to All): Always perform a thorough medical, dental, and lesion-specific history. If any lesion appears suspicious for malignancy (e.g., indurated, non-healing ulcer, rapid growth, fixation, unexplained lymphadenopathy), prioritize urgent referral for biopsy. This checklist is a guide; clinical judgment is paramount. When in doubt, refer.