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Developmental and Stem Cell Biology > Regeneration > Flashcards

Flashcards in Regeneration Deck (4)
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1
Q

What is the blastema?

A

A mass of undifferentiated cells uner wound epidermis that gives rise to structures distal from cut.
Blastemal cells derived locally from mesenchymal cells.

2
Q

Desctibe the need of nerve supply in regeneration

A

Nerve produces essential growth factor - naG

3
Q

describe regeneration in Hydra

A

does not require growth,
the heads of hydra produce signal that inhibits secondary axis induction - stops inappropriate head formation
experiments in hydra suggest formation of extra heads prevented by lateral inhibition.
wnt/beta-catenin expressed at tip of hypostome and more broadly after amputation

4
Q

describe amphibian limb regenration

A

blastema formation through dedifferentiation
blastema grows to form distal structures
positional values of blastema depend on RA signalling and prod1
nerve dependent as nerve produces essential growth factor - naG