Regulatory System

Question 1

1. enhanced by heparin (cofactor)
   - coagulation inhibited
   - fibrinolysis inhibited
2. kunitz-type serine protease
   inhibitor w/ double inhibitor effect
   - coagulation inhibited
   - fibrinolysis inhibited

Answer 1

1. Antithrombin II
   - thrombin, 9,10,11,12, kallikrein
   - plasma
2. Tissue Factor Pathway
   Inhibitor
   - 10, TF/7a complex
   - none

Question 2

1. inhibits plasmin when alpha-2
   antiplasmin is depleted
   - coagulation inhibited
   - fibrinolysis inhibited
2. inhibitor in complement pathway
   - coagulation inhibited
   - fibrinolysis inhibited

Answer 2

1. Alpha-2-Macroglobulin
   - thrombin & kallikrein
   - plasmin
2. C’esterase inhibitor
   - 11,12, Kallikrein
   - plasmin

Question 3

1. cofactor: Protein S; vit.k
   dependent inhibitors of
   plasminogen activators
   - coagulation inhibited
   - fibrinolysis inhibited
2. inhibits plasmin only when a-2
   antiplasmin & a-2 macroglobulin
   are depleted
   - coagulation inhibited
   - fibrinolysis inhibited

Answer 3

1. Protein C
   - 5&8
   - enhances plasmin formation
2. Alpha-1-antitrypsin
   - 11
   - plasmin

Question 4

1. enhanced by protein z (cofactor)
   - coagulation inhibited
   - fibrinolysis inhibited
2. anticoagulant, pro-coagulant,
   fibrinolytic inhibitor
   - coagulation inhibited
   - fibrinolysis inhibited

Answer 4

1. Z-dependent protease
   inhibitor
   - 10,11
   - none
2. Protein C inhibitor
   - Thrombin, APC,
   thrombin-thrombomodulin complex
   - Urokinase, tissue plasminogen activator

Question 5

this also inhibits plasmin only when a-1 antitrypsin depleted

1. coagulation
2. fibrinolysis

Answer 5

Alpha-2-Antiplasmin

1. None
2. Plasmin