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immunology hard things to remember > Remember > Flashcards

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1
Q

A3

A

Hemochromatosis

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2
Q

B8

A

Addison disease

Myasthenia gravis

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3
Q

B27

A

Psoriatic arthritis
Ankylosing spondylitis
IBD associated arthritis
Reactive arthritis (Reiter sx)

PAIR seronegative arthropathies

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4
Q

DQ2 DQ8

A

Celiac disease

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5
Q

DR2

A

Multiple sclerosis
SLE
Hay fever
Goodpasture sx

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6
Q

DR3

A 
Diabetes mellitus type 1
SLE
Graves' disease 
Hashimoto thyroiditis
Addison disease
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7
Q

DR4

A

Rheumatoid arthritis
DM1
Addison disease

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8
Q

DR5

A

Pernicious anemia

Hashimoto thyroiditis

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9
Q

Opsonization

A

C3b IgG

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10
Q

Anaphylaxis

A

C3a c4a c5a

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11
Q

Neutrophil chemotaxis

A

C5a

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12
Q

MAC membrane attack complex

A

C5b-9

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13
Q

Complement Inhibitors

A

CD55(decay accelerating factor) and C1

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14
Q

IL1

A

Fever

Activates endothelial to express adhesion molecules

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15
Q

IL2

A

Stimulate differentiation of Th activates NK cell monocytes
Stimulates B cell division

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16
Q

IL3

A

Stimulates bone marrow

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17
Q

IL4

A 
Stimulates differentiation to Th 2
Enhance class switching to IgE and IgG
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18
Q

IL 5

A 
Enhance class switching to IgA
Th2 growth and differentiation of eosinophils
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19
Q

IL6

A

Stimulates acute phase reactants

Fever

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20
Q

IL 8

A

Neutrophil chemotactan

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21
Q

IL 12

A

Differentiate Th1

Activaste natural killers

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22
Q

TNF alpha

A

Cachexia in malignancy
Mediates septic shock
WBC recruitment

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23
Q

INF gamma

A

Stimulates macrophages
Activaste NK
Use: Chronic granulomatous disease

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24
Q

IL10

A

Attenuates inflammatory response

Also with TGF Beta

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25
Anti basement membrane
Goodpasture sx
26
Anticardiolipin - lupus anticoagulant
SLE and antiphospholipid sx
27
Anticentromere
CREST sx
28
Anti-desmoglein (anti desmosome)
Pemphigus Vulgaris
29
Anti dsDNA - anti smith
SLE
30
Antihemidesmosomes
Bullous pemphigoid
31
Anti-histones
Drug induce SLE
32
Anti-Jo-1 anti SRP Anti Mi2
Polymyositis | Dermatomyositis
33
Antimicrosomal antithyroglobulin
Hashimoto thyroiditis
34
Antimitochondrial
1 biliary cirrhosis
35
ANA (antinuclear)
Non specific | SLE
36
Anti-parietal cell
Pernicious anemia
37
Antiphospholipase A2 receptor
1 membranous nephropathy
38
Anti-Scl-70 (antiDNA topoisomerasa I)
Scleroderma
39
Anti-smooth muscle
Autoimmune hepatitis type I
40
Anti Ro Anti La (anti SSA anti SSB)
Sjogren sx
41
Anti TSH receptor
Graves' disease
42
Anti-Ribonucleoprotein (RNP)
Mix connective tissue disease
43
Voltage gated calcium channel AB
Lamber Eaton sx
44
IgA antiendomisial IgA anti tissue transglutaminase
Celiac disease
45
p-ANCA (MPO ANCA)
Microscopic polyangiitis | Churg- strauss sx
46
c-ANCA (PR3 ANCA)
Wegener granulomatosis
47
Rheumatoid factor
RA IgM ab targets IgG Fc region Anti CCP (anticitrulinated peptide) more specific
48
Aldesleukin (IL2)
Uses: Renal cell carcinoma metastatic melanoma
49
Epoietin alpha (erythropoietin )
Uses: Anemia (specially in renal failure)
50
Recovery of bone marrow
Filgrastim (G-CSF) | Sargamostin (GM-CSF)
51
INF - alpha
Uses: chronic HBV HCV kapossi sarcoma malignant melanoma
52
INF beta
Multiple sclerosis
53
Thrombocytopenia
Romiplostin eltrombopag (thrombopoietin receptor agonist ) Oprelvekin (IL 11)
54
Alemtuzumab
Target CD52 | Use CLL MS
55
Bevacizubam
Target VEGF | Use colorectal cancer Renal cell carcinoma
56
Cetuximab
Target EGFR | Use stage IV colorectal cancer head neck cancer
57
Rituximab
Target CD20 | Use B-Cell non-Hodgkin lymphoma CLL RA ITP
58
Trastuzumab
Target HER2/neu | Uses: Breast cancer
59
Eculizumab
Target complement protein C5 | Uses: paroxysmal nocturnal hemoglobinuria
60
Natalizumab
Target alpha-4 integrin | Uses: MS chron disease
61
Andalizumab Certolizumab Infliximab
Target: TNF alpha | Uses : IBD RA ankylosing spondylitis psoriasis
62
Etanercept
TNF alpha receptor | Uses RA Psoriasis ankylosis spondylitis
63
TGF Beta function
Tissue regeneration and repair

immunology hard things to remember (1 decks)

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