Renal Flashcards

1
Q

Where in the nephron does most reabsorption take place?

A

PCT (Proximal Convoluted Tubule)

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2
Q

Where is ADH synthesized?

A

Hypothalamus

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3
Q

What part of the nephron is variably permeable to water?

A

DCT because of aldosterone and ADH

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4
Q

Describe the structure of the filtration membrane

A
  1. Has glomerular endothelial cells
  2. Has basal lamina
  3. Filtration slits
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5
Q

Where does secretion occur in the nephron?

A

PCT, DCT, collecting ducts

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6
Q

Where in the nephron does most reabsorption take place?

A

PCT

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7
Q

What substances are filtered?

A

Solutes

Plasma proteins

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8
Q

What part of the nephron will be stimulated by ADH?

A

DCT

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9
Q

What parts of the nephron are always permeable to water?

A

PCT and descending limb

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10
Q

What does Angiotensin II do?

A

Stimulates constriction of both afferent and efferent arterioles

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11
Q

What part of the nephron is always impermeable to water?

A

Ascending limb

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12
Q

How does aldosterone affect secretion?

A

Increases Na+ and water reabsorption

Stimulates kidneys to reabsorb K+ and H+ ions secretion into urine

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13
Q

How does aldosterone affect reabsorption?

A

Reabsorb more Sodium and water

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14
Q

Where is ADH released?

A

Posterior pituitary gland

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15
Q

What stimulates the secretion of aldosterone?

A

Angiotensin II

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16
Q

In the presence of ADH, will urine become hypertonic or hypotonic?

A

Hypertonic

17
Q

Trace the blood supply through the kidney.

A

Blood supply into and out of the kidneys progresses to the cortex through renal arteries to segmental, lobar, interlobar, arcuate, And cortical radiate, arcuate, and interlobar veins.

The renal plexus regulates renal bloodflow by adjusting the diameter of renal arterioles and influencing the urine forming role of the nephrons.

18
Q

Describe the juxtaglomerular apparatus.

A

The juxtaglomerular apparatus is a structural arrangement between the afferent Arterial in the distal convoluted tubule that forms granular cells and macula densa cells.

19
Q

Describe the forces that promote or counteract glomerular filtration.

A

Glomerular filtration is passive.

The glomerular filtration rate is the volume of filtrate formed each minute by all the glomeruli of the kidneys combined.

20
Q

Compare the intrinsic an extra in sick controls of the glomerular filtration rate.

A

GFR is held relatively constant through intrinsic auto regulatory mechanisms, and Extrinsic hormonal and neural mechanisms.

Extrinsic neural mechanisms are stress induced sympathetic responses that inhibit filtrate formation by constricting the afferent arterioles

21
Q

Define renal clearance.

A

Renal clearance refers to the volume of plasma that is cleared of a specific substance in a given time.

22
Q

Describe the normal physical properties of urine.

A

Is pale-deep yellow

Slightly aromatic

Higher specific gravity than water

23
Q

Describe the chemical properties of urine

A

95% water

5% solutes

24
Q

List several abnormal urine components and name the condition characterized by the presence of detectable amounts of each

A

Glucose - Glycosuria, caused by diabetes Melitis