Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GEN PATH > Renal 6th Ass > Flashcards

Renal 6th Ass Flashcards

1
Q

What is the MOST likely pathology behind rapidly progressive glomerulonephritis with concomitant diffuse pulmonary hemorrhage?

  • Renal pathology secondary to adaptive changes from systemic disease
  • Presence of circulating anti-glomerular basement membrane antibodies
  • Pathology is currently unknown or is idiopathic
  • Diffuse inflammatory response after severe or systemic infection
A

Presence of circulating anti-glomerular basement membrane antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

44-year-old male visited an out-patient department with symptoms of nausea, vomiting, and general weakness that had developed over the previous 2 weeks. He had history of medication, nonsteroidal anti-inflammatory drugs. On admission to general ward, his serum creatinine level was markedly elevated. A renal biopsy was done and 30 mg of corticosteroid per day was immediately initiated. Subsequently, his serum creatinine level and uremic symptoms dramatically decreased. Based on the case, expected findings on glomerular electron microscopic examination will demonstrate:

  • “Tram-track” appearance due to GBM splitting caused by mesangial ingrowth
  • “Foot processes” effacement
  • Subepithelial immune complex “humps”
  • “Spike and dome” appearance with subepithelial deposits
A

Subepithelial immune complex “humps”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

33-year-old man presents to the clinic with gross hematuria. About 5 days ago, he had fever, runny nose, and sore throat. He is currently asymptomatic. There is no family history of hematuria or renal failure. Physical exam and vital signs are normal. Urinalysis demonstrate dysmorphic RBC’s, RBC’s cast, and trace proteinuria. Serum chemistries are normal. Serum complement and other serologies are normal. Hematuria persist 1 week later. What is the most likely diagnosis:

A

Berger disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The renal lesions associated with diabetes mellitus are the following EXCEPT:

  • Glycogen deposits in the tubular epithelium
  • Nodular glomerulosclerosis
  • Acute pyelonephrit
A

Nephrolithiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Transitional cell carcinoma of the urinary bladder are associated with the following EXCEPT:

  • Prolonged salicylate intake
  • Aniline dyes
  • Schistosomiasis of the bladder
  • Heavy cigarette smoking
A

Prolonged salicylate intake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most common WHO class of Lupus Nephritis.

  • no lesions
  • focal segmental
  • diffuse proliferative
  • mesangial
A

diffuse proliferative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Microscopic features of this lesion in the urinary bladder revealed Infiltration with large foamy macrophages with multinucleated giant cells interspersed with lymphocytes. Michaelis Gutmann bodies are present.

  • Cystitis glandularis
  • Acute suppurative cystitis
  • Tuberculosis
  • Malakoplakia
A

Malakoplakia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In addition to nephritic injury, the other main cause of acute tubular necrosis is:

  • severe hypocomplementemia
  • Sepsis
  • immune complex deposition
  • Ischemi
A

Ischemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

A 28 y/o woman presented with fever, dysuria, urinary frequency and flank tenderness. Urinalysis showed abundant WBC and bacteria. The most likely etiology is:

  • Proteus vulgaris
  • H. influenzae
  • E.coli
  • N. gonorrhea
A

E.coli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Coarse asymmetric renal corticomedullary scarring, deformity of the renal pelvis and calyces, atrophic tubules with eosinophilic casts all suggest:

  • none of the above
  • Chronic pyelonephritis
  • Acute pyelonephritis
  • Nephrotic syndrome
A

Chronic pyelonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

A 28 year old primigravida had hypotensive shock because of postpartum hemorrhage. Her urine output ranged from 60 - 200 ml/24 hours. The basic kidney lesion to explain this decreased urine output among these patients is:

  • Acute tubular necrosis
  • Obstructive uropathy
  • Acute tubulointerstitial nephritis
  • Hemolytic-uremic syndrome
A

Acute tubular necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The most common cause of death in Multiple Myeloma is:

  • infection
  • widespread metastases
  • renal failure
  • bleeding
A

infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Diffuse effacement of foot processes is characteristic of:

  • Idiopathic rapidly progressive glomerulonephritis
  • IgA nephropathy
  • Lipoid nephrosis
  • Lupus ephritis
A

Idiopathic rapidly progressive glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which of the following tests is most valuable in confirming Goodpasture’s syndrome?

  • diffuse linear staining of GBM with IgG
  • diffuse thickening of GBM on electron microscopy
  • granular lumpy bumpy deposits of IgG
  • urine culture for resistant E.coli
A

diffuse linear staining of GBM with IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The renal lesions associated with diabetes mellitus are the following EXCEPT:

  • Nodular glomerulosclerosis
  • Acute pyelonephritis
  • Glycogen deposits in the tubular epithelium
  • Nephrolithiasis
A

Nephrolithiasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Of the complications of acute pyelonephritis enumerated below, one does not belong:

  • Acute episodes of paroxysmal HPN
  • Retroperitoneal abscess formation
  • Pyonephrosis
  • Renal papillary necrosis
A

Retroperitoneal abscess formation

17
Q

28 year old primigravida had hypotensive shock because of postpartum hemorrhage. Her urine output ranged from 60 - 200 ml/24 hours. The basic kidney lesion to explain this decreased urine output among these patients is:

  • Acute tubulointerstitial nephritis
  • Acute tubular necrosis
  • Obstructive uropathy
  • Hemolytic-uremic syndrome
A

Acute tubulointerstitial nephritis

18
Q

Approximately 2 weeks after an episode of pharyngitis, a 13-year old girl abruptly becomes tired, febrile, and nauseous. She has markedly reduced urine output that is cola-colored. Urinalysis shows proteinuria, hematuria, and RBC casts. How many percent of adults recover without incident?

  • 20%
  • 60%
  • 80%
  • 40%
A

60%

19
Q

Approximately 2 weeks after an episode of pharyngitis, a 13-year old girl abruptly becomes tired, febrile, and nauseous. She has markedly reduced urine output that is cola-colored. Urinalysis shows proteinuria, hematuria, and RBC casts.How many percent of children recover without incident?

  • 80%
  • 20%
  • 60%
  • 40%
A

80%

20
Q

Approximately 2 weeks after an episode of pharyngitis, a 13-year old girl abruptly becomes tired, febrile, and nauseous. She has markedly reduced urine output that is cola-colored. Urinalysis shows proteinuria, hematuria, and RBC casts. Describe the cellularity of the glomerulus in this condition.

  • Pauci cellular
  • Normal
  • Pauci cellular & Hypercellular
  • Hypercellular
A

Hypercellular

21
Q

Approximately 2 weeks after an episode of pharyngitis, a 13-year old girl abruptly becomes tired, febrile, and nauseous. She has markedly reduced urine output that is cola-colored. Urinalysis shows proteinuria, hematuria, and RBC casts. What inflammatory cells are increased in this condition?

  • Neutrophils
  • Eosinophils
  • Lymphocytes
  • Monocytes
A

Neutrophils

22
Q

Approximately 2 weeks after an episode of pharyngitis, a 13-year old girl abruptly becomes tired, febrile, and nauseous. She has markedly reduced urine output that is cola-colored. Urinalysis shows proteinuria, hematuria, and RBC casts. What other examination may augment in the diagnosis of the disease?

  • ASO
  • CRP
  • History of 2 weeks sore throat
  • BNP
A

CRP

23
Q

Ten days after recovering from a mild respiratory tract infection, an otherwise healthy, 22 year old man starts passing dark urine; urinalysis shows dysmorphic erythrocytes. The hematuria subsides in 1 week, only to return four more times in the next year. Give your impression.

  • Membranous Glomerulonephritis
  • IgA nephropathy
  • Membranoproliferative Glomerulonephritis
  • Focal Segmental Glomerulosclerosis
A

IgA nephropathy

24
Q

Ten days after recovering from a mild respiratory tract infection, an otherwise healthy, 22 year old man starts passing dark urine; urinalysis shows dysmorphic erythrocytes. The hematuria subsides in 1 week, only to return four more times in the next year. In what part the glomerulus in this condition can you find electron dense deposits?

  • glomerular capillary basement membranes
  • tubular basement membranes
  • mesangium
  • walls of the small veins
A

glomerular capillary basement membranes

25
Q

Ten days after recovering from a mild respiratory tract infection, an otherwise healthy, 22 year old man starts passing dark urine; urinalysis shows dysmorphic erythrocytes. The hematuria subsides in 1 week, only to return four more times in the next year. How many percent of patients with this condition will progress into ESRD?

  • 40%
  • 70%
  • 90%
  • 20%
A

40%

26
Q

A 38 year old woman with morbid obesity has a 2 week history of malaise is found to be hypertensive with peripheral pitting edema. Her serum creatinine is 2.5 mg/dL (nl<1.3), and a 24 hour urine has 3.7 g of protein (nephrotic range). Her antinuclear antibody titer is negative. She does not respond to corticosteroid therapy. What is your diagnosis?

  • IgA nephropathy
  • Membranoproliferative Glomerulonephritis
  • Membranous Glomerulonephritis
  • Focal Segmental Glomerulosclerosis
A

Focal Segmental Glomerulosclerosis

27
Q

A 38 year old woman with morbid obesity has a 2 week history of malaise is found to be hypertensive with peripheral pitting edema. Her serum creatinine is 2.5 mg/dL (nl<1.3), and a 24 hour urine has 3.7 g of protein (nephrotic range). Her antinuclear antibody titer is negative. She does not respond to corticosteroid therapy. For this condition, what microscopic finding would aid in the diagnosis?

  • Focal mesangial proliferation
  • Glomerulus is hypercellular
  • Spikes at the basement membrane may be present
  • Capillary loops are thinned out
A

Focal mesangial proliferation

28
Q

A 38 year old woman with morbid obesity has a 2 week history of malaise is found to be hypertensive with peripheral pitting edema. Her serum creatinine is 2.5 mg/dL (nl<1.3), and a 24 hour urine has 3.7 g of protein (nephrotic range). Her antinuclear antibody titer is negative. She does not respond to corticosteroid therapy.
The most common etiology of this disease:

  • Idiopathic
  • Penicillamine
  • Oat cell carcinoma
  • Genetic predisposition
A

Idiopathic

29
Q

A 38 year old woman with morbid obesity has a 2 week history of malaise is found to be hypertensive with peripheral pitting edema. Her serum creatinine is 2.5 mg/dL (nl<1.3), and a 24 hour urine has 3.7 g of protein (nephrotic range). Her antinuclear antibody titer is negative. She does not respond to corticosteroid therapy.
How many patients with this condition will progress to ESRD?

  • 50%
  • 75%
  • 25%
  • 100%
A

50%

30
Q

The most characteristic renal finding in diabetes mellitus

  • Diffuse glomerulosclerosis
  • Hyaline arteriolosclerosis
  • Acute pyelonephritis
  • Nodular glomerulosclerosis
A

Nodular glomerulosclerosis

GEN PATH (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions