Renal disease

Question 1

What is the definition of microalbumuria on a 24 hour urine test?

Answer 1

30-300mg in 24 hours.

Question 2

What is the definition of proteinuria on a 24 hour urine test?

Answer 2

> 3.5grams in 24 hours.

Question 3

What is the definition of microalbuminuria on a morning sport albumin to creat ratio?

Answer 3

Males > 2.5mg/mmol

Females > 3.5mg/mmol

Question 4

Why is microalbuminuria relevant in terms of risk of complications associated with diabetes?

Answer 4

Diabetes confers a higher risk of CVD

Microalbuminuria confers double the risk of CVD in an already increased risk diabetic.

Question 5

What is the definition of proteinuria on a spot urine albumin to creatinine ratio?

Answer 5

> 30mg/mmol

Question 6

Is there a benefit of good glycaemic control on prevention of diabetic nephropathy?

Answer 6

No in DCCT study

Question 7

What is the benefit of ACE I in prevention of diabetic nephropathy?

Answer 7

in T1DM, 50% lower albumin excretion rate at 2 year in treated vs untreated patients.

Question 8

How common is diabetic nephropathy in T1DM and T2DM?

Answer 8

40% of T1DM, 5-40% of T2DM.

In patients with macroalbuminuria, renal function is likely to decline by 10% per year.