Renal Physiology (3A) Flashcards
(33 cards)
Entry into the lumen includes (2)
filtration and secretion
Exit from the lumen includes (2)
reabsorption into the blood vessel and excretion of urine our of the tubule
_____, ___ and ___ lead to excretion.
filtration, reabsorption, secretion
Where does filtration occur?
glomerulus
Where does reabsorption and secretion occur?
tubular sites
FORMULA
amount excreted =
amount filtered + amount secreted - amount reabsorbed
In the ____ layers, the fenestrated endothelial, basement membrane, and the podocytes with filtration slits have an important role in ____.
filtration, filtration
What type of molecules are held back?
large proteins or albumin
Why are the large molecules held back? (3)
- pore size not large enough
- pores and BM have (-) charged proteins
- podocyte have slits that remain covered with semiporous membranes that are selective in the type of particles that can enter
The 2 proteins of the slit membrane found in the podocyte layer are
nephrins and podocins
What is filtered though the glomerulus?
water, electrolytes, glucose, aa., fatty acids, vitamins, urea, uric acid, creatine
What remains in the blood stream and cannot enter to filtration pore?
blood cells, plasma proteins, large anions, protein-bound minerals and hormones, most molecules >8nm
The molecules that remain in the plasma are considered ___.
plasma inflow
Ultrafiltration occurs at the membrane between the __ and the __ and involves the movement of __ molecules while holding back others.
glomerulus, capillaries, some
(Every turn of the filtration process results in different molecules entering the filtrate outflow)
The molecules that exit the plasma and enter the glomerular space includes that of the ____ outflow.
filtrate
Proteinuria does not happen in ___ individuals and occurs when ___ escapes from the kidney into ___.
healthy, protein, urine
Factors that are involved in glomerular filtration includes (3)
- net glomerular filtration pressure is ALWAYS +
- GF pressure inititates urine formation by forcing the protein-free filtrate from plasma–> glomerulus –> Bowman’s capsule
- concentration of protein in Bowman’s space is so low that the osmotic force due to protein in BS is considered 0
Forces that favours filtration is the
glomerular capillary BP (Pgc)
Forces that oppose filtration are (2)
fluid pressure in the bowman’s capsule (PBs)
osmotic pressure due to the protein in the plasma (piGC)
Forces that favours filtration is directed towards the
bowman’s capsule
Forces that opposes filtration is directed towards the
glomerulus
The largest force in the equation involves
the glomerular capillary BP directed into the Bowman’s capsule
The largest force that opposes filtration is
osmotic force due to protein plasma
Net glomerular filtration pressure includes (FORMULA)
Pgc - PBs - piGC
