Flashcards in Renal Structure and Function Review Deck (11):
What is the nephron?
Structural and functional unit f the kidney, ~1million/kidney
Comprised of glomerulus and tubule
What are the major functions of the kidneys?
1. Waste excretion
2. Electrolyte balance
3. Hormone synthesis
4. BP regulation
5. Glucose homeostasis
What hormones are synthesised in the kidneys?
-EPO production (cortex)
-Vit D activation
-Renin production (JG apparatus)
What are mesangial cells?
Structural cells that support the vascular tree. Contractile and produce vasoactive substances to help control blood flow
What are the cells of the glomerulus?
1. Mesanigal cells
2.Capillary endothelial cells
3. Visceral epithelium (podocytes)
4. Parietal epithelium
What are capillary endothelial cells?
One of the cells of the glomerular filtration barrier; help form the plasma filtration apparatus due to their sinusoidal nature and glycocalcyx.
What are the podocytes?
Visceral epithelium; one of the cells of the glomerular filtration barrier and help form plasma filtration apparatus due to their interdigitated foot process that form slit diaphragms.
What is the parietal epithelium?
Lines the interior of Bowman's capsule and contains a podocyte progenitor population
Explain effect of PGs, NSAIDs, ACEi and ANGII on the renal arterioles.
What is normal urine output?