renal transporters Flashcards Preview

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Flashcards in renal transporters Deck (7)
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1
Q

PCT

A

APICAL

  • Na/H antiporter
  • Na coupled cotransporter (AA/glucose)
  • MDR transporter for cations

BASOLATERAL

  • Na/K ATPase
  • channels for AA/glucose

aquaporins

2
Q

descending loop

A

aquaporins only

3
Q

thin ascending loop

A

Na+ channels
Cl- channels

IMPERMEABLE to water

4
Q

thick ascending loop

A

APICAL
-NaK/2Cl cotransporter

BASOLATERAL
-Na/K ATPase

PARACELLULAR TRANSPORT (lumenal positive)

5
Q

DCT

A

APICAL

  • Na/Cl cotransporter
  • Ca channels

BASOLATERAL

  • Na/K ATPase
  • Ca ATPase
  • Ca/3Na exchanger
6
Q

collecting duct (principal cells)

A

APICAL

  • Na+ channel
  • K+ channel
  • aquaporin

BASOLATERAL
-Na/K ATPase

7
Q

collecting duct (a-intercalated cells)

A

carbonic anhydrase:

CO2 + H2O –> H+ (secreted apically) + HCO3- (reabsorbed basolaterally)