Flashcards in Renin release Deck (6):
What 3 factors trigger release of renin?
1) sympathetic stimulation
2) renal hypoperfusion
3) decreased sodium delivery to distal tubule (macula densa)
What are 3 factors that cause renal hypo-perfusion?
a) decreased circulating volume
b) low cardiac output (usually high volume state)
c) renal artery stenosis
What is the effect of diuretics on renin?
increase renin release - "because of decreased renal blood flow"......
What is the effect of clonidine on renin release?
inhibits it because less sympathetic stimulation of B1 receptors on juxtoglomerular cells
What is the effect of arteriolar vasodilators on renin release?
slightly increased because arteriolar dilation reduced total peripheral resistance which causes slight hypoperfusion of kidneys....