Repair and Regeneration Flashcards
(11 cards)
Complete restoration of tissue architecture and function is called?
Regeneration (good as new)
Restoration of function but altered architecture is called?
Repair (scars)
What are the 4 general phases of tissue repair?
1-Hemostasis (Clot formation)
2-Inflammatory (infiltration of immune cells)
3-Reparative phase (proliferative, migration of cells)
4-Wound contraction and scarring
Exposure of collagen in sub endothelium to circulating von willebrand factor causing platelet aggregation is typical of what stage of hemostasis?
Primary hemostasis (platelet plug)
*Secondary Hemostasis (blood coagulation) happens simultaneously or just after
What are the two pathways of Secondary hemostasis?
- Extrinsic (factor VII and tissue factor interaction)
- Intrinsic (initiated by damaged endothelium (collagen exposure))
What do both extrinsic and intrinsic pathways of blood coagulation eventually activate?
Fibrinogen (soluble) to fibrin (insoluble)
*Prothrombin converts to thrombin to do this
What happens during the reparative/proliferation phase?
Cells migrate under fibrin clot and proliferate forming new hemidesmosomes and collagen scaffold. Angiogenesis also takes place
What cells work to draw wound edges together?
Myofibroblasts (increased actin/myosin)
Why is there no scar formed in periodontal repair?
Immediate remodeling of collagen by ligament fibroblasts
*important for tooth movement. GF are added or membranes used to encourage ligament reattachment and limit epithelial invasion
What are the 3 primary zones (outer to inner) for dental caries?
1-Surface and body (surface zone re-mineralizes, body is primary zone of demineralization)
2-Dark zone (zone of increasing demineralization)
3-Translucent zone (leading edge of caries)
Dentin formed between surviving dentin and restorative material preventing micro leakage is called what?
Dentin bridge
