Replication, Heteroplasmy And The Purifying Selection Flashcards
1
Q
What does TEFM do?
A
TEFM inhibits formation of G-quadruplex and allows RNA to synthesise the full transcript
2
Q
How many conserved sequence blocks are there?
A
Three
CSBI, II, III
3
Q
How does transcription start?
A
RNA polymerase POLRMT initiates transcription at the LSP, stops at CSBII and then there is an RNA/DNA transition step
4
Q
Where is the RNA/ DNA transition step?
A
Between CSBII and OH (191)
5
Q
What are three proteins key to mtDNA replication?
A
DNA polymerase gamma
TWINKLE
SSB
