Repro/GU SM Lectures Flashcards
(52 cards)
1
Q
Ascending Infection
A
- leads to chorioamnionitis (mom) or funisitis (fetus)
- causes include GBS, enterococci, E.coli, ureaplasma, candida, herpes
2
Q
Descending Infection
A
- leads to villitis
- causes include syphilis, tuberculosis, listeria, CMV, rubella, toxoplasmosis
3
Q
Maternal Serum Markers in Fetal Down Syndrome
A
- increase in hCG and inhibin A
- decrease in alpha-fetoprotein and unconjugated estriol
4
Q
Contraindications to Medical Abortions in First Trimester (mifepristone+misoprostol)
A
- ectopic pregnancy
- IUD
- corticosteroid use
- hemorrhagic disorders/poryphoria
- concurrent anticoagulant use
- chronic adrenal failure
- allergy
5
Q
Non-Estrogen therapies for VMS
A
- SSRI’s (fluoxetine, escitalopram), do not use with tamoxifen
- SNRI’s (venlafaxine)
- clonidine
- gabapentin
6
Q
GnRH analogues
A
- gonadorelin (GnRH synthetic)
- leuprolide (GnRH super-agonist)
- cetrorelix (GnRH receptor antagonist)
7
Q
Gonadotropins
A
- follitropins alpha and beta
- lutropin alpha
- chorionogonadotropin alpha
8
Q
Androgens
A
- testosterone propionate (slow releasing depot)
- methyltestosterone (orally effective synthetic preparation)
- stanozolol (orally effective synthetic preparation with slightly enhanced anabolic/androgenic ratio)
9
Q
Androgen antagonists
A
- flutamide (receptor antagonist)
- finasteride and dutasteride (5-alpha reductase inhibitor)
- gossypol (damages seminiferous tubules and decreases sperm)
10
Q
Estrogen
A
- estradiol benzoate (semisynthetic, long-acting)
- ethinyl estradiol (orally effective synthetic estrogen)
- conjugated equine estrogens (Premarin)
- diethylstilbesterol (non-steroidal, orally effective, long-acting, carcinogenic)
11
Q
Progestin
A
- medroxyprogesterone (oral or depot)
- norethindrone, levonorgestrel (oral)
12
Q
SERMS
A
- tamoxifen
- fulvestrant (absent initial stimulatory effect of estrogen)
13
Q
Non-neoplastic ovarian cysts
A
- follicular cyst/cystic follicle
- corpus lutein cyst
- non neoplastic epithelial cyst (ie. ovarian surface epithelial cyst and ciliate tubal inclusion cyst)
14
Q
Types of ovarian neoplasia
A
- surface epithelial tumors
- sex cord stromal tumors
- germ cell neoplasms
15
Q
Common sites of “implants” by borderline subtype of serous epithelial ovarian tumor
A
omentum, pelvic sidewall, diaphragm, uterine serosal surface
16
Q
Common primary tumors that metastasize to ovary
A
- endometrial carcinoma
- cervical SCC
- breast
- Krukenberg’s tumor (signet ring cell tumor from stomach)
- mucinous adenocarcinoma from appendix and colon
17
Q
Tumor Markers
A
CA 125: ovarian epithelial tumor
CEA: mucinous ovarian tumor
HCG: embryonal carcinoma, choriocarcinoma
Inhibin: granulosa cell tumor
Lactase Dehydrogenase: dysgerminoma
Alpha fetal-protein: endodermal sinus tumor, embryonal carcinoma
18
Q
Common sites of endometriosis
A
ovaries, uterine ligaments, rectovaginal septum, peritoneum, and appendix
19
Q
Contents within the Deep Perineal Pouch
A
- deep transverse perineal muscle
- external urethral sphincter
- bulbourethral gland
20
Q
Episiotomy (enlargement of the distal birth canal to facilitate difficult birth)
A
- Median cut (skin, vaginal wall, perineal body)
- Mediolateral cut (skin, vaginal wall, bulbospongiosus, superficial transverse perinei, UG diaphragm)
21
Q
Mechanism of Erection
A
NO–> GC–> cGMP–> PKG–> increased uptake of Ca++ into intracellular stores and potassium efflux–> cell hyperpolarization
22
Q
Contributing factors to Preterm Premature Rupture of Membranes
A
- alteration in cervical stromal composition
- induction of amniotic membrane matrix metalloproteinases
23
Q
Gonadotropes
A
- acts via GPRCR and second messenger cAMP
- FSH–> sertoli cells–> spermatogenesis
- LH–> leydig cells–> steroidogenesis
24
Q
Articulations of the innominate bone
A
- ilium articulates with sacrum
- ischium articulates with pubis and ilium
- pubis articulates with opposite pubis
25
Components of the pelvic brim
- pubic tubercles and crest
- pecten pubis
- arcuate line of ilium
- ala of sacrum
- sacral promontory
26
Pelvic Inflammatory Disease (progression of symptoms)
mucopurulent vaginal discharge--> midline abdominal pain and abnormal vaginal bleeding--> bilateral lower abdominal and pelvic pain with nausea and vomiting
27
Disseminated gonococcal disease
fever, joint pain, septic arthritis, tenosynovitis, rash
28
Treatment for STI's
- ceftriaxone for N. gonorrhoeae
- azithromycin or doxycycline for chlamydia
- penicillin G for syphilis
- metronidazole for Trichomonas vaginalis and bacterial vaginosis
29
Tertiary Syphilis
- general paresis
- tabes dorsalis
- arygl robertson pupil
- aortitis
- gummas
30
Perinatal Infection (routes and bugs)
- Transvaginal (HIV, HSV, chlamydia, HBV)
- Transplacental (HIV, syphilis, HSV)
- Breast feeding (HIV, HBV)
31
Primary sex cords
seminiferous tubules in men, rete ovarii in women
32
Mesonephric duct
ductus deferens and epididymus in men, Gartner's duct in women
33
Ureteric bud
ureter, pelvis, calyces, collecting tubules
34
UG sinus
urinary bladder, urethra, lower vagina, prostate and bulbourethral glands (male), urethral and paraurethral and greater vestibular glands (female)
35
Oocyte maturation
First meiotic division begins before birth and arrested in prophase--> at puberty first meiotic division is completed resulting in secondary oocyte and first polar body--> second meiotic division begins before ovulation and stops at metaphase--> second meiotic division is completed upon fertilization
36
Epithelium of Vagina
non-keratinized stratified squamous, pyknotic nuclei with "washed-out" appearance
37
SF1
- regulates HPG axis
| - regulates genes including ACTH receptor, LH, AMH
38
SRY (testes-determining factor)
- induces sertoli cell differentiation
- migration of mesonephric cells into gonadal ridge
- male-specific vasculature
39
Sox9
- downstream of SRY
- expressed in sertoli cells
- regulates AMH and chondrogenesis (campomelic dysplasia)
40
Features of Turner Syndrome
Short stature, low hairline, shield-shaped thorax, widely spaced nipples, shortened metacarpals, small finger nails, brown spots (nevi), constriction of aorta, poor breast development, elbow deformity, streak gonads, lymphedema, horseshoe kidney, duplication of renal pelvis (aberrant bifurcation of calyces)
41
PCOS (consequence of low FSH levels)
the proportion of early growing (primary) follicles is significantly increased with a reciprocal decrease in the proportion of primordial follicles compared to normal ovaries
42
Most common causes of secondary amenorrhea (not including pregnancy, OCPs, and breast-feeding)
hypogonadotropic hypogonadism (secondary to weight loss), PCOS, premature ovarian failure, Asherman's syndrome
43
Follicular Reserve
- Measured by AMH levels
| - AMH is produced by pre and small antral follicles, whose number correlates with follicular reserve
44
Bacterial Pathogens implicated in UTI
- Outpatient: E.coli (80%), Staph. Saprophyticus (5%), proteus/klebsiella/enterococci (15%)
- Inpatient: E.coli (50%), proteus/klebsiella/enterococci (20%), pseudomonas/serratia/acinetobacter (30%)
45
Generations of Progestins
-1st generation (norethinedrone)
-2nd generation (levonorgesterel, norgestrel)
-3rd generation (etonogestrel)
Androgenic effects (2>1>3)
46
Core differences between low and high risk HPV
- Low risk HPV (mild dysplasia, condyloma, productive infection, transient lesions, clinically undetected, low risk HPV, surveillance or laser/cryo ablation)
- High risk HPV (CIN3, loss of coordination between viral expression and epithelial differentiation, persistent, pre-malignant, excisional procedure/hysterectomy)
47
Type 1 and Type 2 mutation patterns for ovarian epithelial tumor carcinogenesis
Type 1- KRAS/BRAF/PTEN, low grade serous or mucinous
| Type 2- p53, BRCA 1/2, high grade serous
48
Postnatal diagnoses identified commonly secondary to antenatal hydronephrosis
Ureteropelvic junction obstruction, vesicoureteral reflux, ureterovesical junction obstruction, ureteroceles, posterior urethral valves
49
Etiologies of Ureteropelvic Junction Obstruction
- aperistaltic segment
- intrinsic narrowing
- ureteral polyps
- high insertion
- kinking secondary to periurethral fibrosis
- crossing vessel (lower pole renal artery)
50
Weigert-Meyer rule
- ureter associated with the lower pole of the kidney inserts more laterally and refluxes
- ureter associated with the upper pole of the kidney inserts more medially and obstructs
51
Renal Cell Carcinoma (sub-type, cell origin)
```
Clear cell (proximal tubules)
papillary cell (proximal tubules)
chromophobe (intercalated cell of CCD)
oncocytoma (intercalated cell of CCD)
```
52
AD Heritable Syndromes for RCC (5%)
VHL- 3, renal cell carcinoma, retinal hemangioblastomas, pheochromocytomas, neuroendocrine tumors
Hereditary papillary RC- 7, papillary carcinoma
Hereditary leiyomyomatosis RCC- 1, papillary carcinoma, leiyomyomas, leiyosarcomas
Birt-Hogg-Dube- 17, oncocytomas, clear cell, chromophobe, cutaneous papules
