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Flashcards in Reproduction Deck (29):
1

function of FSH in men

causes spermatogenesis in testes

2

function of LH in men

causes testosterone secretion by the testes

3

function of FSH in women

causes follicle growth and oestrogen secretion

4

function of LH in women

causes ovulation, and causes corpus luteum to make progesterone

5

how does oestrogen influence LH release?

oestrogen causes high freq pulsation of GnRH, stimulating LH release (surge!!)

6

how does progesterone influence FSH release?

progesterone causes low freq pulsation of GnRH, stimulating FSH release

7

how soon after the LH surge is ovulation?

about 34 hours

8

true or false: oestrogen causes
- thinner vaginal wall
- fertile fluid
- increased vaginal pH

False - thickened wall
True - thin cervical mucus
False - decreased pH, more lactic acid

9

does LH bind to theca or granulosa cells?

theca

10

FSH causes progesterone formation - T / F ?

FSH causes oestrogen
LH causes progesterone

11

effects of progesterone on...
- smooth muscle
- body temperature
- endometrium

relaxes muscle
increases temp
thickens the enodetrium

12

what genetic abnormality causes amenorrhea?

Turners

13

high levels of what hormone in the blood causes secondary amenorrhea?

Hyperprolactinaemia

14

wtf is Hypogonadotrophic hypogonadism.. ?

type 1 - hypothalamic pituitary failure.

15

oligomenohea occurs in hypogonadotrophic hypogonadism - true?

false - always amenorrhea

16

what is more common - hypothalamic pituitary failure or dysfunction?

dysfunction = 85%

17

treatment option for premature ovarian failure?

HRT - not that successful

18

what hormone causes PCOS?

Excess LH !!
leads to excess androgens and insulin resistance

19

what "C.C" is first line treatment of PCOS?

Clomifene Citrate

20

what is a downside of clomifene citrate?

20% of women are resistant to it

21

what is 2nd line treatment for PCOS?

Daily injection of gonadotrophins - directly stimulate the ovaries

22

what is a risk of gonadotrophin injection for infertility in PCOS?

higher risk of twins

23

what surgery can be attempted to combat infertility in PCOS?

Laproscopic ovarian diathermy

24

is metformin effective in PCOS?

yes!!
can stimulate ovulation and help with androgen symptoms as well as insulin resistance

25

sperm are made in....
- Leydig cells
- Sertoli cells
- seminiferous tubules

seminiferous tubules

(Sertoli cells are part of this but they only make ABG)

26

how and when is testosterone made?

when LH binds to Leydig cells causing cholesterol conversion --> T

27

90% of testosterone is taken up by Sertoli cells - what action does it have?

causes release of mature sperm from sertoli

28

What controls the BTB?

blood testes barrier controlled by TESTOSTERONE AND FSH

29

where are Leydig cells ?

interstitial - between the seminiferous tubules