Reproductive Flashcards

(97 cards)

1
Q

mastitis

A

inflammation of mammary gland
often bacterial (not always)
mainly dairy cattle but all species can get it

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2
Q

mastitis - treatment

A

antimicrobials
antiinflammatories - NSAIDs, steroids
nursing
supportive therapies

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3
Q

mastitis - antimicrobials

A

intramammary or parenteral
some bacteria very responsive

e. coli - most common cause, often not responsive to antibiotics

need to be used for enough days
definitely use if have bacteremia

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4
Q

mastitis - anti-inflammatories

A

NSAIDs -
meloxicam, flunixin meglumine
help combat endotoxemia
always useful - pain stops them wanting to get up so will eat less and hang out in gross places

steroids -
decrease inflammation
not analgesic
immunosuppresive - not great if an infection
local preparations - potential may help distribute antimicrobials

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5
Q

mastitis - nursing

A

stripping - should do routinely, flushes out bacteria and toxins
fluids
electrolytes
getting up and turning over down cows

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6
Q

mastitis - supportive therapies

A

feeding
supplementation

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7
Q

mastitis - prevention

A

identify issues early - bulk milk
environmental hygiene
milk parlour hygiene
teat sealing
nutrition
bedding management
vaccines

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8
Q

neonatal sepsis - equine

A

infection + systemic inflammatory response
leading cause of mortality in foals <1 weeks old
usually failure of passive transfer
cormorbid with other neonatal diseases - increased liklihood of not eating properly, lying down in grim places leading to poor immune function and infection

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9
Q

neonatal sepsis - signs - equine

A

non specific
lethargy
depression
seizure
unwillingness to suckle
tachy or bradycardia
tachypnoea - metabolic acidosis
pethachiae on gums or ears
recumbancy
dehydration
cold extremities
pale mm
scleral congestion
localised signs of infection

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10
Q

neonatal sepsis - diagnosis - equine

A

signs and history - not sucking, premature foals, dystocia, materal illness, failure of passive transfer
bacteriology - blood or synovial fluid
hematology - leukopenia and neutropenia
biochem - hypoglycemia common, azotemia, liver enzymes, increased lactate, increased acute phase proteins

IgG

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11
Q

neonatal sepsis - treatment - equine

A

maintain homeostasis
control infection

antibiotics
fluids - resuscitation and maintenance - correct hypovolemia then reassess
respiratory support - intranasal oxygen (hypoperfusion of tissues)
NSAIDs - use with caution in neonates - treating systemic inflammation and coagulopathies
nutritional support - keep blood glucose up
nursing - often round the clock - biosec, catheter care, turning to stop pressure sores

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12
Q

neonatal encephalopathy - equine

A

new born foal
non-infectious
neuro signs
immediate post partum

either -
hypoxic ischemic encephalopathy - cerebral hypoxia, adverse peripartum events
neonatal maladjustment syndrome - persistant elevation of in utero hormones - normal adjustment not happened

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13
Q

neonatal encephalopathy - signs - equine

A

behavioural changes - lack of interest in mare, inappropriate nursing, weird vocalisation
altered mentation - depression, stupr, somnolence, difficult to rouse, coma
cranial nerve dysfunction - no suckle reflex, weak tongue tone, tongue protrusion, dysphagia
CNS dysfunction - tremors, proprioception deficits, central blindness, ireegular respiratory patterns, seizures

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14
Q

neonatal encephalopathy - ddx - equine

A

sepsis
electrolyte abnormalities
hypoglycemia
meningitis
EHV 1
birth defects - lavender foal, hydroencephalus, hydraencephaly

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15
Q

hypoxic ischemic encephalopathy (HIE) - equine

A

mulitsystem organ dysfunction common along with neuro signs

risk factors -
placental disease
premature placental separation
maternal illness
dystocia
c section
birth trauma

supportive treatment

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16
Q

neonatal maladjustment syndrome (NMS) - equine

A

similar presentation with HIE but without the risk factors

failure in transition in uterine unconscious state to extrauterine conscious state
usually acheived by physcial compression during 2nd stage labour - triggers endocrine changes

rapid birth may be a risk factor

treat with foal squeeze (squeezey rope)

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17
Q

Neonatal Isoerythrolysis - equine

A

most common cause of jaundice in foals
anemia - RBCs destroyed by maternal antibodies to foal RBCs in colostrum
blood group incompatibility
mostly thoroughbreds
normal foal at birth then get ill from colostrum

good prognosis in mild/uncomplicated cases, less good if concurrent sepsis or renal disease or very sever signs

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18
Q

Neonatal Isoerythrolysis - signs - equine

A

at 2-5 days after birth

Vary with degree of anemia and amount of colostrum ingested
May develop metabolic acidosis due to anaerobic tissue metabolism

Lethargy
Weakness
Jaundice
Anorexia
Pyrexia
Multi organ failure – severe
Death – severe
CNS effects – seizure – severe
Dyspnoea – reduced o2 carrying ability – severe

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19
Q

Neonatal Isoerythrolysis - diagnosis - equine

A

tentative diagnosis any foal with lethargy, jaundice and anemia

presence of antibodies in colostrum or mare serum against foals RBCs - lysis of foal RBCS
jaundice foal agglutination test - not as sensitive but quick patient side test

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20
Q

Neonatal Isoerythrolysis - treatment - equine

A

monitor - PCV and signs
avoid stress/exertion
blood transfusion if PCV very low - risk of transfusion reaction, can overload liver with iron
antibiotics - prevent sepsis
hyperimmune plasma if failure of passive transfer

not much point taking them off the mare - not getting colostrum after a couple of days anyway

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21
Q

Neonatal Isoerythrolysis - prevention - equine

A

blood typing before breeding - some groups should be bred with caution

jaundiced foal agglutination test before foal nurses if mare has history of this before

muzzle foals of mare with history of this and use alternative colostrum

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22
Q

best practice at birth

A

clean and dry environment
move baby away from trampling
place in front of mum
encourage to lie sternal
encourage dam to clean
don’t swing baby
if struggling to breath percuss chest and massage fluid out of nose and mouth

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23
Q

dystocia

A

most commonly caused by foetal oversize

oedema
bruising
fractures
hypoxic foetus (due to reduced oxygen from compression of umbilical cord or premature placental separation)
metabolic acidosis - lactic acid production and build up
respiratory acidosis - poor lung function
reduced suck reflex - due to acidosis
failure of passive transfer - reduced colostrum intake from reduced sucking

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24
Q

dystocia - diagnosis of acidosis/hypoxia

A

time to sternal recumbancy over 5 mins
reduction or absence of suck reflex

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25
colostrum contents
high protein, fat and vitamins - energy immunoglobulins growth factors leukocytes
26
factors affecting colostrum quality
timing when collected from mum - decreased IgG over time breed parity pre partum nutrition length of dry period abortion/induction mastitis
27
factors affecting colostrum intake
inadequate supply - quantity or quality udder conformation poor mothering maternal disease poor neonatal vigour - reduced sucking
28
factors affecting colostrum absorption
time from birth to sucking method of administration acidosis - reduces absorption ability induction of parturition
29
failure of passive transfer
major risk for all neonatal disease especially if fail to suckle within 6 hours holteins particularly bad for it
30
investigating failure of passive transfer
serum immunoglobulin - refractometer - total prteins zinc sulphate turbidity sodium sulphate turbidity radial immunodiffusion nasal stick test - IgG lateral flow - IgG sample from 24 hours to 7 days consider effect of dehydration on total proteins
31
failure of passive transfer - prevention
good pre partum nutrition avoid dystocia tube feed colostrum ASAP supervision keep good quality frozen colostrum colostrum substitutes
32
equine - normal neonatal milestones
righting reflex in seconds suck reflex - 5-10 mins trying to stand - 30 mins standing - 1 hour nursing - 2 hours meconium passed - in 24 hours urine - dilute, large volumes in 6 hours for colts and 10 hours for fillies 2-3L colostrum nurse 5-7 times per hour
33
prematurity/dysmaturity - characteristics
low birth weight short, sily hair floppy ears domed head weakness prolonged time to stand lax flexor tendons incomplete ossifciation or tarsal and carpal bones
34
prematurity/dysmaturity - risk factors
health of dam in gestation foaling environment ease of delivery gestational age at birth placental abnormalities placental transfer or maternal immunoglobulin
35
consequences of failure of passive transfer - foals
septicemia increased infectious disease in first 4 months
36
causes of retained foetal membranes - equine
failure of detachment of microvillous attachments usuallt tips of non gravid uterine horn dystocia premature delivery abortion c section uterine intertia delayed uterine involution placentitis
37
retained foetal membranes - predisposing factors - equine
older mare induced parturition c section delayed uterine involution dystocia obstetric manipulation abortion still birth twinning retention at a previous birth
38
retained foetal membranes - sequelae - equine
range from no effects - death (so can be real emergency) metritis laminitis myocarditis
39
retained foetal membranes - history - equine
fetal membranes still visible after 3-6 hours recent foaling or abortion failure to complete stage 3 within 3 hours of birth dystocia abnormalities at foaling sick mare placental membranes not been seen or incomplete placenta only
40
retained foetal membranes - signs - equine
retained membranes hanging out pyrexia dullness depression reduced appetite reduced milk production endotoxemia abdominal pain - 12-48 hours post partum colic vaginal discharge
41
retained foetal membranes - treatment - equine
aim to - maintain uterine contractility control inflammation control bacterial proliferation tie up placenta hanging out so don't stand on it - weight of placenta can help it fall out oxytocin (can cause colic but very effective) uterine lavage - can cause contractions/separation, wash bacteria out and delay onset of sepsis antibiotics - after removal NSAIDs - bute or flunixin - for the colic after oxytocin manual removal - could cause hemorrhage, pulmonary embolism, uterine inveesion, prlapse or infection - ensure microvilli not attached still and all membranes out
42
retained foetal membranes - indications for referral - equine
signs of sepsis history or signs of laminitis lack of experience in handling these cases
43
retained foetal membranes - risk factors - cattle
common in diary cows dystocia uterine torsion abortion stillbirth c-section twins immunosuppression negative energy balance selenium/vitamin E deficiency hypocalcemia
44
retained foetal membranes - consequences - cattle
delayed uterine involution longer time to first service decreased fertility increased risk endometritis, metritis, ketosis, mastitis decreased milk production less dramatic than in horsest
45
retained foetal membranes - treatment - cattle
manual removal - could lead to increased metritis and can cause trauma to uterus and endometrium - more chance of bacteria build up and septicemia antibiotic pessary in uterus - expensive and milk withdrawal systemic antibiotics - only if systemically ill oxytocin/prostaglandin PFG2a
46
retained foetal membranes - prevention - cattle
keep cos comfortable reduce stress around parturition adequate and balanced nutrition consider history - more likely to retain if have done before
47
retained foetal membranes - other farm species
sheep - rare goats - more than sheep but not common pigs - rare but increasing with breeding for more piglets, prolific sows more prone longer parturition a risk factor
48
failure to cycle - causes - equine
time of year lactational anoestrus failure to cycle post foaling persistant CL ovulation failure ovarian neoplasia ovarian hematoma genetic abnormalities
49
time of year - cycle - equine
long day breeders - melatonin in response to darkness inhibitis hypothalamus april-october - ovulatory can control artifically - artifical light or blue LED mask on one eye can also control with hormones exposure to stallion in neighbouring paddock to advance season improved BCS also helps to cycle earlier
50
foal heat
oestrus at 7-12 days post partum then switch to regular 21 day cycle may have variable periods of anoestus after foaling then take a while to cycle normally
51
lactational anoestrous
may only start cycling again when foal weaned
52
persistant CL - equine
CL hangs around longer than notmal and delays onset of oestrous causes - ovulation late in dioestrous chronic endometritis - lose ability to produce prostaglandin to lyse CL, older mares lutenised anovulatory follicle try and lyse by giving prostaglandin high progesterone indicates presence of luteal tissue
53
ovulation failure - equine
usually anovulatory follicle insufficient hormone production higher incidence in older mare
54
ovarian neoplasia - equine
granulosa cell tumour - hormonally active, stallion like behaviour usually unilateral, other ovary not working while tumour is there and gets small cystadenoma, teratome, cystadenoma - slow growing and hormonally inactive - other ovary functions normally
55
ovarian hematoma - equine
excessive post ovulation hemorrhage may need removed if big enough to damage ovary architecture
56
genetic abnormalities - equine
gonadal dysgenesis - sterile - missing sex chromosome, normal external but small ovaries and underdeveloped uterus mosaics/chimeras - some normal and some abnormal cells - sub or infertile no treatment, but uncommon
57
failure to conceive - causes - equine
anatomically normal and cycling but not getting in foal endometritis uterine abnormalities oviduct abnormalities
58
endometritis - equine
inflammation of inner lining of uterus most common cause of subfertility breeding induced endometritis - normal - inflammatory response to insemination, should clear in 24-48 hours once debris flushed out by natural processes venereal pathogens - natural mating or contaminated semen usually older mares susceptible usually no external signs may see discharge ultraousn - oedema, fluid in lumen - graded by amount of fluid and character sampling - swab, low volume flush, or biopsy treatment - oxytocin or pgf2a - stimulate contraction to remove debris uterine lavage exercise - helps push fluid out antibiotics/antifungals - c&s address predisposing factors - conformation, contamination at breeding
59
uterine abnormalities - equine
uterine cysts - older mares, lymphatic origin visible on US can interfere with mobility of conceptus, prevent implantation and be misinterpreted as pregnancy adhesions - usually from trauma or previous dystocia areas of scarring inhibit implantation foreign bodies - recurrent non responsive endometritis if remove should return to normal neoplasia - leiomyoma - only an issue if obstrucitve or hemorhagic
60
pregnancy failure - equine
twinning early embryonic loss abortion placentitis
61
twinning - equine
rate of twin conception high in thoroughbreds placenta can't provide enough nutrients usually abort around 7-9 months early identification and pinching before fixation
62
early embryonic loss - equine
loss of pregnancy before 70 days intrinsic factors - endometrial disease maternal age - oocyte quality decreases progesterone deficiency - not seen often in horses extrinsic factors - systemic disease - any that can endotoxemia, lead to increased systemic prostaglandin and luteolysis nutrition - poor BCS toxins iatrogenic - handling in embryo transfer
63
abortion - equine
between 70-300 days may result from systemic disease usually don't find out why infectious causes - ascending placentitis EHV1 equine vial arteritis MRLS (caterpillar, we don't have it here) lepto nocardiform placentitis non-infectious causes - twinning umbilical cord torsion congenital abnormalities maternal disease mare not usually affected systemically
64
placentitis - equine
ascending - infection starting at caudal pole then spreading cranially may have vulval diacharge may have premature udder development can lead to abortion if extensive ultrasound - thickness of uterus and placenta at caudal pole antibiotics NSAIDs progesterone supplement pentoxyfyline - improve quality of RBCs prepare for compromised foal
65
causes of abortion - equine
viral bacterial fungal twinning placental disease foetal disease maternal disease premature placental separation no diagnosis in 50% cases
66
management of abortion - equine
try and establish cause rule out infectious causes ensure not having outbreaks examine foetus and membranes isolation until infectious ruled out flushing repairing tears
67
types of placentitis - equine
ascending - most common - microorganisms access cervical portion of placenta via cervix diffuse/multifocal - hematogenous spread, widespread infection and inflammation - lepto, salmonella, candida focal mucoid - south america - nocardiform
68
diagnosis - placentitis - equine
usually older multiparous mares no clinical signs until advanced - discharge, premature udder development and lactation US - assess thickness at caudal pole of placenta
69
treatment - placentitis - equine
antibiotics NSAIDs pentoxyfyline - improves deforability in RBCs to improve perfusion to placenta alternogest - mitigates prostaglandin induced abortion aspirin
70
prevention - placentitis - equine
predisposed by poor comformation regular monitoring in future pregnancies prepare for compromised foal
71
uterine torsion - equine
cause unknown uncommon last 4 months mild colic - recurrent if severe torion risk of uterine rupture diagnosis - rectal palpation correct by rolling mare under GA or surgery severe troision --> occlusion of uterine blood flow --> ischemia to uterus and foetus --> abortion
72
ventral abdominal swelling - equine
variable swelling leaves a dent if you poke the belly mostly just normal to have oedeam towards term abdominal wall rupture hydrops
73
abdominal wall rupture - equine
older mares swelling and pain draft horses associated with hydrops and twinning can be from trauma - kicking can be seen in conjunction with pre-pubic tendon tear - tear at insertion with pelvis ventral abdomen drops lordosis reluctance to move blood in milk treatment - abdominal support restricted exercise analgesia prognosis dependant on size of tear, should retire from breeding after
74
hydrops - equine
excess fluids build up in one of the placental compartments can lead to wall rupture may have spontaneous abortion, if not then usually need to induce parturition hydroallantois - chorioallantois not regulating fluid hydramnion - usually associated with foetal abnormality - uncommon older mares rapid onset abdominal distension last trimester low grade colic lethargy anorexia dyspnoea - uterus pushing cranially diagnosis - rectal palpation, ultrasound
75
vaginal varicose veins - equine
common cause of vulval discharge lots of blood so looks alarming but mostly normal nothing wrong with foetus or uterus usually older mares grape like structures on roof of vagina can cauterise with formalin, laser or heat (or just leave them)
76
reproductive colic - equine
differentiate peri-partum conditions causing colic from non-reproductive causes late pregnancy - more prone to colon displacement and torsion could be due to foetal activity
77
maceration
cervix open allows bacteria entry
78
mummification
foetal death with persistent CL closed cervix no contractions
79
causes of fertilisation failure - farm
bad AI timing delayed ovulation poor uterine environment
80
early embryonic death - farm
day 1-19 genetic defects poor quality ova endometritis lack of interferon tau heat stress infection
81
late embryonic death - farm
day 19-40 same risk factors as early embryonic death also impact of management factors
82
abortion - farm
day 40-270 infectious and non infectious causes
83
infectious abortion causes - sheep
chlamydia toxoplasmosis salmonella campylobacter brucella abortus border disease fungal
84
non-infectious abortion causes - sheep and cattle
genetic defects heat stress management stress nutrition iatrogenic
85
infectious abortion causes - cattle
brucella abortus - notifiable leptospirosis trueperella pyogenes listeria monocytogenes campylobacter spp neospora caninum salmonella BVDV fungal
86
brucella abortus
notifiable zoonotic long survival outside body ingestion or venereal spread hematogenous spread to uterus --> placentitis and endometritis stays latent but usually only abort once abortion storm in naive herds late pregnancy abortion lactating dairy cows routinely screened for antibodies management of metritis rather than treatment of the brucella
87
leptospirosis
spread through infected urine, abortion products or venereal spread carried and excreted by sheep - advise against co-grazing with cattle rapid multiplaication in udder and uterus --> bacteremia sudden milk drop late abortion pyrexia microscopic agglutination test (MAT), ELISA, flourescent antibody test antibiotics to reduce shedding vaccine available
88
listeria monocytogenes
sporadic winter abortions contaminated silage transiet fever and illness abortion at or after times of illness usually late abortion abortion unrelated to CNS signs isolate organism from liver, abosmasum, foetus, placenta or vaginal discharge prevention - good silage hygiene and storage
89
neospora caninum
carried by dogs most commonly diagnosied abortion cause in cows UK chronic infection repeat abortions can have live congenitally infected calves - pass through herd abortion at 5-6 months abortion storms in naive animals mummified foetus prevention - restrict dog access to feed and calving/abortion products
90
chlamydia abortus
zoonotic common in sheep - enzootic abortion spread by ingestion of abortion products of infected ewes usually not ill at time of abortion latent infection, abortion following year after this usually immune vaccine available
91
toxoplasma gondii
carried by cats outcome dependent on stage of gestation when infected non pregnant - immune early pregnancy - early embryonic death late pregnancy - foetal death, mummification or weak lambs strawberry cotyledons vaccine available but no treatment
92
campylobacter spp
sporadic abortion storms - usually for one season then immune brought in by infected sheep or contaminated feed abortion 1 month before lambing aborted lambs are fresh red inflamed placenta no vaccine available
93
induction of abortion - medical - farm
PGF2A - day 7-150 PGF and steroid (dexamethasone) - days 150-270 PGF or steroid - day 275+
94
metritis - farm
usually e. coli of actinobacillus pyogenes clinical metritis - abnormally large uterus, not necessarily systemically ill, purulent discharge pureperal metritis - watery brown discharge, 21 days post calving, systemic illness grading - 0-3 - endometritis - normal discharge to 100% pus 4-5 - metritis - brown, smelly discharge to systemically unwell toxic metritis usually don't treat grade 1-2
95
uterine prolpase
abdominal straining in 3rd stage parturition especially if membranes still attached risk factors - decreased uterine tone - hypocalcemia, dystocia manual extraction of calf and membranes long stage 2 labour excessive straining replace as quickly as possible can lead to uterine artery rupture treatment - epidural to replace uterus, remove placenta, sugar solution may help to shrink uterus (draws out water)
96
bull breeding soundness exam
scrotal circumference - related to fertility and fertility of daughters palpation - even, firm prepuce and penis - eg warts, lesions accessory sex glands - palpable per rectum - size, swelling, shape volume and density of semen gross and progressive motility morphology - bent tails, detached heads, proximal droplets, distal droplets libido and ability to serve - able to mount, penis extrudes eyes, jaw, heart, BCS, lungs, lameness handle samples very carefully - temerpature changes can cause shock
97