Large surface area yields rapid absorptiob
Micronized
Receptors found in uterus, vagina, ovaries and mammary glands and prostate
ErA
Clinical use of synthetic combination of contraceptive
Regulate menses Amenorrhea like PCOS Relieves dymenorrhea Hypogonadisn Menopausal hormonal therapy
Uses of synthetic estrogen alone
Hirsutism
Relieve mild to moderate depression
Given to prevent pregnancy
Palliative treatment for prostate CA
SERMS
Tamoxifen
Raloxifene
Toremifene
Bazedoxifene
Non steroidal anti estrogen
Clomiphene
Fulvestrant
Given for a precursor for endometrial cancer
Tamoxifen
Indicated for px at risk of breast CA
Raloxifene
Increases LH and FSG amplitude pulses
Clomiphene
Increases intracellular proteolytic degradation of era and erb
Fulvestrant
Drug that displaces warfarin
Tamoxifen
If the px has er negative what drug that is not given
Tamoxifen
Prevention and treatment of osteoporosis
Raloxifen
CI or precautions for SERMS
VTE
Stroke
Heavy smoker
Clinical use of clomiphene citrate
Ovulation induction
Abnormal uterine bleeding
Endometrial hyperplasia
PCOS
CI for clomiphene acetate
Ovarian enlargement
Visual disturbance
21 carbon progesterone has what
Antagonize aldosterone
Norethindone
Norgestrel
Desogestrel binds to what
SHBG
Albumin
Used in management of paraphilia
Depo-provera
Anti progesterone drugs
Mifeprestone
Ulipristal acetate
Action of ulipristal acetate
Anti proliferative effect on the endometrium
Inhibit ovulation
Therapeutic use of ulipristal acetate
Emergency contraceptive in rape
First generation estrogen
Femenal
Nordiol
Second generation estrogen and progesterone
Microgynon Micropil Nordette Trinordiol Logynon
Third generation pill
Gynera Meliane Marvelon Mercilon Gracial Minulet
Fourth gen pill
Qlaira
Yasmin
Yaz
Decreased incidences with progesterone alone
Ovarian
Endometrial
Benign fibrocystic breast disease
Relative contraindications for progesterone
Smoking Controlled htn Fibroid tumor Dm History of dyslipidemia Sickle cell Active gall bladder disease More than 50yr Elective surgery Migraine
Used for endometriosis
Danazol
Clinical use of cyproterone acetate
Adjunct in prostate ca Precoccious puberty Masculinzation and acne Reverse sexuality Anti androgenic effect
Used for prostatic ca with gnrh
And excess androgen in women
Flutamide
Bilcalutamide
Nilutamide
Enzalutamide
Clinical uses of finasteride and dutasteride
BPH
Prostatic CA
Hirsutism
Baldness