Reproductive Hormones

Question 0

Norethindrone

Answer 0

Progesterone analog
Oral
Combination contraceptive and IUD
Cross react with steroid receptors

Question 1

Medroxyprogesterone acetate

Answer 1

Progesterone analog
IM
contraceptive (depo shots)

Question 2

Drospirenone

Answer 2

Progesterone analog
Oral
Combination contraceptive (yaz)
Enhanced mineral corticoid and androgen antagonist

Question 3

Ulipristal

Answer 3

Progesterone analog, PRM
Oral RX
Post coital contraceptive
More effective than norgestrel (5 days after sex)
used in ER
Blocks ovulation
AE: N/V, HA, Dizziness, breast tenderness, abdominal and leg cramps

Question 4

Mifepristone

Answer 4

Progesterone analog
Oral
Progesterone antagonist

Question 5

Ethinyl estradiol

Answer 5

Estradiol analog
Oral
Most common combination contraceptive

Question 6

Estrone sulfate

Answer 6

Estradiol analog
Oral
Hormone replacement therapy

Question 7

Diethylstilbestrol

Answer 7

Non steroidal estrogen
First utilized
No longer in use

Question 8

Bisphenol A

Answer 8

Non steroidal estrogen
Environmental contaminant
Estrogen agonist

Question 9

Tamoxifen

Answer 9

Non steroidal estrogen 
Oral
SERM
breast -
bone ++, endometrium +, CV +, vagina epi +

Question 10

Clomiphene Fulvestrant

Answer 10

estrogen receptor antagonist

used to induce ovulation

Question 11

Raloxifene

Answer 11

SERM
breast -
bone ++, CV +
post menopause symptoms
osteoporosis
ER+ breast CA

Question 12

Ospemifene

Answer 12

SERM
breast -
bone +, CV +, vagina epi ++
Vaginal atrophy
menopause symptoms

Question 13

Testosterone routes

Answer 13

transdermal gel
buccal tab
IM

Question 14

Danazol

Answer 14

Testosterone analog
PO
Hepatic toxicity

Question 15

androgen adverse effects

Answer 15

Virilization
suppression of hypothalamic-pituitary axis
edema
Jaundice 
Hepatic carcinoma
gynecomastia

Question 16

Finasteride

Answer 16

(propecia)
anti-androgen
5 alpha reductase inhibitor
AE persistent sexual dysfunction

Question 17

Dutesteride

Answer 17

(avodart)
anti-androgen
5 alpha reductase inhibitor
AE persistent sexual dysfunction

Question 18

Flutamide, Bicalutamide, nilutamide

Answer 18

Anti-Androgens

Question 19

Ketoconazole

Answer 19

Steroid synthesis inhibitor

site of action: Testes, ovaries, adrenals

Question 20

spirolactone

Answer 20

steroid synthesis inhibitor, anti-androgen, anti-mineralcorticoid
Inhibit 17 alpha hydroxylase

Question 21

Gonadorelin

Answer 21

Synthetic GnRH
IV
Delayed and precocious puberty
endometriosis
dysmenorrhea
ovulation induction protocol

Question 22

luprolide

Answer 22

GnRH agonist
IV
Long acting
Suppress Hypothalamic-pituitary axis

Question 23

cetrorelix

Answer 23

IV

GnRH antagonist

Question 24

Monophasic combicontra

Answer 24

21 days on, 7 off

Question 25

Biphasic combicontra

Answer 25

21 on, 7 off | 1-10 progesterone low, 11-21increased

Question 26

Triphasic combicontra

Answer 26

21 days, 3 phase of increase progesterone

Question 27

combicontra risk and benifits

Answer 27

decreased efficacy with rifampin and anticonvulsants decrease ovarian cysts, fibrocystic breast disease decreased ovarian and breast CA risk increase HDL and decrease LDL

Question 28

norgestrel 2x-4x

Answer 28

Progesterone analog oral otc post coital contra 3 days after sex AE: effective only prior to ovulation, HA, N/V, Dizziness, breast tender, abdominal and leg cramps