Reproductive Pharmacology Flashcards Preview

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Flashcards in Reproductive Pharmacology Deck (16)
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1

Oestrogen: Acts on, Uses, ADE (e.g. ethinylestradiol)

Acts on oestrogen receptors. Promotes breast growth, bone mass, endometrial thickening.
Used in HRT, COC
ADE: increased breast, endometrial and ovarian cancer risk. Migraines. Increased clotting, vasodilation. Hyperpigmentation. Uterine bleeding. Oedema (sodium/water retention). Breast Tenderness. Migraines

2

Raloxifene

SERM. Reduces oestrogen driven breast cancer growth, partial agonist for bone growth. Ednometrial antagonist. Used in breast cancer/oesteoporosis.
ADEL clotting, VTE risk. Increased TG/HDL

3

Tamoxifen

SERM. Reduced oestrogen driven breast cancer growth. Partial agonist for bone growth. Agonist for endometrium.
ADEs:VTE risk, clotting, increased TG/HDL

4

Clomiphene

Oestrogen antagonist. Induces ovulation. Acts at hypothalamus/puitary, but agonist at ovary and reduces negative feedback (FSH/GnRH increase gives LHsurge/ovulation).
Used for PCOS
ADE: GI discomfort, bleeding. can cause ovarian overstimulation syndrome

5

Norethisterone

Progesterone agonist.
Suppresses GnRH, decreases endometrial proliferation, increases cervical mucus viscosity, decreased sodium reabsoption, decreased breast development.
Used as contraception (POP, COCP, implant), HRT with oestrogen. Endometriosis treatment. Endometrial carcinoma treatment
ADEs: acne, fluid retention, wt change, depression, libido effects, breast discomfort, menstrual irregularities, increased VTE risk

6

Mifepristone

Progestoerone antagonist (competitive with partial agonist activity). Used for medical aborption with prostaglanding (gemeprost)
Has anti glucocorticoid activity, so CI in women taking glucocorticoids

7

Testosterone /analogues

AR agonist. Promotes spermatogenesis, gives feedback to ant pit (LH secretion feedback). Anabolic on muscle/bone/sebum. Increased EPO.
Used in bodybuilding, pit/testicular hypogonadism, female hyposexuality
ADEs: limited at endogenous. Increase prostate cancer risk, sodium retention (oedema/HT), infertility, erthryocytosis, gynaecomastia, liver damage

8

Flutamide

Androgen antagonist. Used in prostate cancer, and to counter spironolactone induced hisutism.

9

Cyproterone

Androgen antagonist - chemical castration

10

Finasteride

5-alpha reductase inhibitor. Prevents testerone to DHT conversion - used in BHP, androgenic alopoecia.

11

Anastrazole

Aromatase inhibitor. Prevents conversion of testosterond to oestradiole, and androstenedione to oestrone. Used in breast cancer treatment (causes menopausal ADEs)

12

Synthetic GnRH (gonadorelin)

GnRH agonist/antagonist. If pulse the agonist, continous is antagonist. Causes gonadal suppresion.
Used in breast cancer, prostate cancer, endometriosis, large uterine fibroids.
ADEs: menopausal symptoms, osteoporosis, androgen deprivation symtpoms

13

Doxazosin

alpha blocker. Antiadrenergic drug with vasodilating actions. Used in BPH, Raynaulds and HT.
ADEs: postural hypotension, dizziness, priapism,fatigue, SOB>

14

Levornogestrel

Used for emergency contraception

15

Tamsulosin

Alpha adrenergic blocker. Used in BPH. Can cause SOB, priapism, postural hypotension, dizziness.

16

Medroxyprogesterone acetate

Prosterone receptor agonist (thickens cervical mucus). Used for dysfunctional uterine bleeding, endometriosis, endometrial, renal, breast cancer. Contraception. HRT
ADEs: depression, fluid retention