Respiratory Flashcards
The primary functions of the respiratory system are
1) smell, 2) air conduction, and 3) the exchange of oxygen and carbon dioxide between the animal and the environment, referred to as respiration.
The primary functions of the respiratory system are 1) smell, 2) air conduction, and 3) the exchange of oxygen and carbon dioxide between the animal and the environment, referred to as respiration. This provides oxygen to body tissues for .
cellular respiration, removes the waste product carbon dioxide, and help to maintain acid-base balance
Portions of the respiratory system are also used for non-vital functions, such as
sensing odors, speech production, and for straining, such as during childbirth or coughing
Respiration occurs at the ________, which lies at the most distal part of the respiratory tract.
air-blood interface
two crucial functions of the respiratory tract are
air conduction and respiration
The importance of considering these two roles is apparent during respiratory diseases in which interference with either _____________ (such as obstructive respiratory disease) or the _______________ (such as bacterial bronchopneumonia) results in life-threatening hypoxia.
air conduction
air-blood interface
Alveoli – alveoli walls are composed of a single layer of
squamous epithelium (type 1 alveolar cells or pneomocytes), scattered cuboidal type II alveolar cells secrete surfactants and antimicrobial proteins; no gas exchange, secrete oily surfactant in humid/watery environment ( (liquid has the tendency to stick together, try to collapse alveoli) this can be prevented by surfactant. Has an extensive but small capillary network.
– connect adjacent alveoli and equalizes air pressure throughout the lungs.
Alveolar pores
– keep alveolar surfaces sterile, 2 million dead macrophages/hour carried by cilia – throat – swallowed.
Alveolar macrophages
-chamber that connect to multiple individual alveoli, surrounded by fine elastic fibers and pulmonary capillaries, only to respond to stretching, and recoil; skeletal muscles would be too thick, (we do not want this to prevent gas flow to capillaries)
Alveolar sacs
– this is the relationship between the pressure and volume of a gas, gasses fill the container: if the container size is reduced – the pressure increases (P). Pressure varies inversely with volume. Changes in thoracic/lung volume of the pleural cavities – the movement of the chest wall or diaphragm will directly affect the volume of the lung by changing the volume of pleural cavities.
Boyle’s Law
- trachea branches into two primary bronchi (right/left), one on each lung secondary bronchi branch off primary; enter lung lobes (2 on left lung, 3 on right), one to each lobe tertiary bronchi (9-10 branches each lung) supply bronchopulmonary segment - C shaped rings are now offset, protects from all directions - bronchioles branch into alveoli
Brochial tree
- like the arterioles of the cardiovascular system - varying bronchiole diameter controls the amount of resistance to airflow - extreme bronchoconstriction can almost completely block passage ways no cartilage, all smooth muscle *KEY: look at arteries and veins, pulmonary artery takes deox blood to lungs
Bronchioles
- cuboidal epithelial cells with apical microvilli located within and distal to bronchioles. Club cells are rich in metabolic enzymes (cytochrome P450 enzymes) and therefore serve a major role in the biotransformation of inhaled xenobiotics.
Club cells (Clara cells)
– the pathway moving air; no gas exchange, includes all structures from nasal cavity to larger bronchioles, this also cleanses, warms and humidifies the air and cools the air on way out (maintains homeostasis), facilitates the exchange, needs a head for diffusion, lines with respiratory mucosa with cilia; traps and get rid of particles before they go into lungs; pseudostratified ciliated columnar epithelium.
Conducting zone
- columnar epithelial cells that produce and secrete mucin, a glycoprotein that is a major constituent of mucus. Histologically, goblet cells have swollen, basophilic to poorly staining cytoplasm (representing cytoplasmic mucin vesicles). Goblet cells are abundant within the respiratory tract and gastrointestinal tract.
Goblet cells
– oxygen and carbon dioxide exchange between lungs and blood.
External Respiration
– oxygen and carbon dioxide exchange between systemic blood vessels and tissues
Internal Respiration
Nose/Pharynx - air enters throughexternal naresor nostrils of thenosepasses into the nasal cavity and then back into thepharynx- nasal conchae increase surface area and swirl air through twists and turns - The pharynx (throat) is a muscular tube shared by respiratory and digestive systems, lined with stratified squamous epithelium -epithelial layers in nose highly vascular; mucus membrane binds large particles.
Larynx - air enters larynx throughglottis(opening)uvula:end of soft palate, prevents air/food from going into the nasal cavity - made of 9 cartilages, ligaments, and skeletal muscles.
- projects over the glottis and covers the glottis during swallowing
elastic cartilage; all other structures have hyaline cartilage
Epiglottis
- Scroll-like structures within the nasal cavity that are composed of a core of thin bone surrounded by connective tissue and lined by respiratory epithelium. The nasal turbinates function to help warm and humidify air and trap particulates.
Nasal turbinates
- Tall, pseudostratified sensory epithelium within the caudal portions of the nasal cavity that contains a population of chemoreceptor cells, olfactory receptor cells, that generate the sensation of smell.
Olfactory epithelium
- A pseudostratified mucosal epithelium composed of columnar epithelial cells with apical cilia often admixed with goblet cells. This epithelium is characteristic of the upper respiratory tract (nasal cavity, sinuses, nasopharynx), eustachian tube, trachea, and large bronchi.
Respiratory epithelium
Respiratory membrane - where simple diffusion of gases takes place Three layers:
- squamous epithelial cells lining the alveoli 2. endothelial cells of adjacent capillary 3. fused basement membranes between alveolar and endothelial; each tissue has its own basement membrane. Diffusion occurs rapidly because the distance is small and both oxygen and carbon dioxide are lipid soluble