Respiratory Flashcards
(101 cards)
What are the categories of acute asthma?
Moderate
-PEFR 50-75% best or predicted
-Normal speech
-RR less than 25/min
-Pulse less than 110 bpm
Severe
-PEFR 33-50% best or predicted
-Can’t complete sentences
-RR > 25/min
-Pulse > 110 bpm
Life threatening
-PEFR < 33% best or predicted
-Oxygen sats < 92%
-Silent chest, cyanosis or feeble respiratory effort
Bradycardia, dysrhythmia or hypotension
Exhaustion, confusion or coma
In addition, a normal pCO2 in an acute asthma attack indicates exhaustion and should, therefore, be classified as life-threatening.
What is lights criteria?
exudates have a protein level of >30 g/L, transudates have a protein level of <30 g/L
if the protein level is between 25-35 g/L, Light’s criteria should be applied. An exudate is likely if at least one of the following criteria are met:
pleural fluid protein divided by serum protein >0.5
pleural fluid LDH divided by serum LDH >0.6
pleural fluid LDH more than two-thirds the upper limits of normal serum LDH
What are the other characteristic pleural fluid findings for rheumatoid arthritis, tuberculosis
Low glucose
What are the other characteristic pleural fluid findings for pancreatitis, oesophageal perforation
raised amylase
What are the other characteristic pleural fluid findings for systemic lupus erythematosus (SLE)
low complement (C3, C4)
pleural effusions occur in approximately 30-50% of SLE patients during the course of their disease and may be the presenting feature
What are the other characteristic pleural fluid findings for mesothelioma, pulmonary embolism, tuberculosis
heavy blood staining
What are the other characteristic pleural fluid findings for pulmonary malignancy
Lymphocyte-predominant effusions are usually due to a chronic pleural process such as malignancy or tuberculosis.
Neutrophil-predominant pleural effusions in contrast are usually due to an acute response. Malignancy is the second commonest cause of exudative pleural effusion, so is an important one to remember.
What are the other characteristic pleural fluid findings for pulmonary infarction
haemorrhagic gross appearance and mesothelial cells.
What investigation should be done for pleural effusions?
Imaging:
posterioranterior (PA) chest x-rays should be performed in all patients
ultrasound is recommended: it increases the likelihood of successful pleural aspiration and is sensitive for detecting pleural fluid septations
contrast CT is now increasingly performed to investigate the underlying cause, particularly for exudative effusions
Pleural aspiration
as above, ultrasound is recommended to reduce the complication rate
a 21G needle and 50ml syringe should be used
fluid should be sent for pH, protein, lactate dehydrogenase (LDH), cytology and microbiology
What should be done for patients with Pleural infection?
All patients with a pleural effusion in association with sepsis or a pneumonic illness require diagnostic pleural fluid sampling
if the fluid is purulent or turbid/cloudy a chest tube should be placed to allow drainage
if the fluid is clear but the pH is less than 7.2 in patients with suspected pleural infection a chest tube should be placed
What is the Management of recurrent pleural effusion?
Options for managing patients with recurrent pleural effusions include:
recurrent aspiration
pleurodesis
indwelling pleural catheter
drug management to alleviate symptoms e.g. opioids to relieve dyspnoea
What is sarcoidosis?
Sarcoidosis is a multisystem disorder of unknown aetiology characterised by non-caseating granulomas. It is more common in young adults and in people of African descent
What are the features of sarcoidosis?
acute: erythema nodosum, bilateral hilar lymphadenopathy, swinging fever, polyarthralgia
insidious: dyspnoea, non-productive
cough, malaise, weight loss
ocular: uveitis
skin: lupus pernio
hypercalcaemia: macrophages inside the granulomas cause an increased conversion of vitamin D to its active form (1,25-dihydroxycholecalciferol)
What Syndromes associated with sarcoidosis?
Lofgren’s syndrome is an acute form of the disease characterised by bilateral hilar lymphadenopathy (BHL), erythema nodosum, fever and polyarthralgia. It usually carries an excellent prognosis
Heerfordt’s syndrome (uveoparotid fever) there is parotid enlargement, fever and uveitis secondary to sarcoidosis
What is Acute respiratory distress syndrome (ARDS) ?
Acute respiratory distress syndrome (ARDS) is caused by the increased permeability of alveolar capillaries leading to fluid accumulation in the alveoli, i.e. non-cardiogenic pulmonary oedema. It is a serious condition that has a mortality of around 40% and is associated with significant morbidity in those who survive.
What are the causes of Acute respiratory distress syndrome (ARDS) ?
infection: sepsis, pneumonia
massive blood transfusion
trauma
smoke inhalation
acute pancreatitis
Covid-19
cardio-pulmonary bypass
What are clinical features of Acute respiratory distress syndrome (ARDS) ?
dyspnoea
elevated respiratory rate
bilateral lung crackles
low oxygen saturations
What is the criteria for Acute respiratory distress syndrome (ARDS) ?
Criteria (American-European Consensus Conference)
acute onset (within 1 week of a known risk factor)
pulmonary oedema: bilateral infiltrates on chest x-ray (‘not fully explained by effusions, lobar/lung collapse or nodules)
non-cardiogenic (pulmonary artery wedge pressure needed if doubt)
pO2/FiO2 < 40kPa (300 mmHg)
What are they key investigations for Acute respiratory distress syndrome (ARDS) ?
A chest x-ray and arterial blood gases are the key investigations.
What is the management for Acute respiratory distress syndrome (ARDS) ?
due to the severity of the condition patients are generally managed in ITU
oxygenation/ventilation to treat the hypoxaemia
general organ support e.g. vasopressors as needed
treatment of the underlying cause e.g. antibiotics for sepsis
certain strategies such as prone positioning and muscle relaxation have been shown to improve outcome in ARDS
Acute respiratory distress syndrome can only be diagnosed in the absence of…
of a cardiac cause for pulmonary oedema (i.e. the pulmonary capillary wedge pressure must not be raised)
What is pulmonary wedge pressure?
Pulmonary Capillary Wedge Pressure (PCWP) is a measurement that tells us about the pressure in the left side of the heart, especially the left atrium.
left ventricular end diastolic pressure
Why is it important?
It helps diagnose causes of pulmonary edema (fluid in the lungs).
If PCWP is high (>18 mmHg), it suggests that the heart (especially the left side) is failing to pump blood forward properly (e.g., in heart failure).
If PCWP is normal or low, but the patient still has lung problems (like in ARDS), it suggests the issue isn’t from heart failure but from lung damage itself.
Quick summary:
High PCWP → Think heart problem (like heart failure).
Normal/low PCWP → Think lung problem (like ARDS).
What is the most common organism causing infective exacerbations of COPD?
Haemophilus influenzae- most common
Streptococcus pneumoniae
Moraxella catarrhalis
The most common viral infective causes of COPD exacerbations are
respiratory viruses
account for around 30% of exacerbations
human rhinovirus is the most important pathogen