Respiratory Flashcards

(101 cards)

1
Q

What are the categories of acute asthma?

A

Moderate
-PEFR 50-75% best or predicted
-Normal speech
-RR less than 25/min
-Pulse less than 110 bpm

Severe
-PEFR 33-50% best or predicted
-Can’t complete sentences
-RR > 25/min
-Pulse > 110 bpm

Life threatening
-PEFR < 33% best or predicted
-Oxygen sats < 92%
-Silent chest, cyanosis or feeble respiratory effort
Bradycardia, dysrhythmia or hypotension
Exhaustion, confusion or coma

In addition, a normal pCO2 in an acute asthma attack indicates exhaustion and should, therefore, be classified as life-threatening.

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2
Q

What is lights criteria?

A

exudates have a protein level of >30 g/L, transudates have a protein level of <30 g/L

if the protein level is between 25-35 g/L, Light’s criteria should be applied. An exudate is likely if at least one of the following criteria are met:

pleural fluid protein divided by serum protein >0.5

pleural fluid LDH divided by serum LDH >0.6

pleural fluid LDH more than two-thirds the upper limits of normal serum LDH

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3
Q

What are the other characteristic pleural fluid findings for rheumatoid arthritis, tuberculosis

A

Low glucose

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4
Q

What are the other characteristic pleural fluid findings for pancreatitis, oesophageal perforation

A

raised amylase

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5
Q

What are the other characteristic pleural fluid findings for systemic lupus erythematosus (SLE)

A

low complement (C3, C4)

pleural effusions occur in approximately 30-50% of SLE patients during the course of their disease and may be the presenting feature

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6
Q

What are the other characteristic pleural fluid findings for mesothelioma, pulmonary embolism, tuberculosis

A

heavy blood staining

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7
Q

What are the other characteristic pleural fluid findings for pulmonary malignancy

A

Lymphocyte-predominant effusions are usually due to a chronic pleural process such as malignancy or tuberculosis.

Neutrophil-predominant pleural effusions in contrast are usually due to an acute response. Malignancy is the second commonest cause of exudative pleural effusion, so is an important one to remember.

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8
Q

What are the other characteristic pleural fluid findings for pulmonary infarction

A

haemorrhagic gross appearance and mesothelial cells.

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9
Q

What investigation should be done for pleural effusions?

A

Imaging:
posterioranterior (PA) chest x-rays should be performed in all patients

ultrasound is recommended: it increases the likelihood of successful pleural aspiration and is sensitive for detecting pleural fluid septations

contrast CT is now increasingly performed to investigate the underlying cause, particularly for exudative effusions

Pleural aspiration
as above, ultrasound is recommended to reduce the complication rate
a 21G needle and 50ml syringe should be used
fluid should be sent for pH, protein, lactate dehydrogenase (LDH), cytology and microbiology

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10
Q

What should be done for patients with Pleural infection?

A

All patients with a pleural effusion in association with sepsis or a pneumonic illness require diagnostic pleural fluid sampling
if the fluid is purulent or turbid/cloudy a chest tube should be placed to allow drainage
if the fluid is clear but the pH is less than 7.2 in patients with suspected pleural infection a chest tube should be placed

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11
Q

What is the Management of recurrent pleural effusion?

A

Options for managing patients with recurrent pleural effusions include:
recurrent aspiration
pleurodesis
indwelling pleural catheter
drug management to alleviate symptoms e.g. opioids to relieve dyspnoea

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12
Q

What is sarcoidosis?

A

Sarcoidosis is a multisystem disorder of unknown aetiology characterised by non-caseating granulomas. It is more common in young adults and in people of African descent

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13
Q

What are the features of sarcoidosis?

A

acute: erythema nodosum, bilateral hilar lymphadenopathy, swinging fever, polyarthralgia

insidious: dyspnoea, non-productive

cough, malaise, weight loss

ocular: uveitis

skin: lupus pernio

hypercalcaemia: macrophages inside the granulomas cause an increased conversion of vitamin D to its active form (1,25-dihydroxycholecalciferol)

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14
Q

What Syndromes associated with sarcoidosis?

A

Lofgren’s syndrome is an acute form of the disease characterised by bilateral hilar lymphadenopathy (BHL), erythema nodosum, fever and polyarthralgia. It usually carries an excellent prognosis

Heerfordt’s syndrome (uveoparotid fever) there is parotid enlargement, fever and uveitis secondary to sarcoidosis

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15
Q

What is Acute respiratory distress syndrome (ARDS) ?

A

Acute respiratory distress syndrome (ARDS) is caused by the increased permeability of alveolar capillaries leading to fluid accumulation in the alveoli, i.e. non-cardiogenic pulmonary oedema. It is a serious condition that has a mortality of around 40% and is associated with significant morbidity in those who survive.

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16
Q

What are the causes of Acute respiratory distress syndrome (ARDS) ?

A

infection: sepsis, pneumonia
massive blood transfusion
trauma
smoke inhalation
acute pancreatitis
Covid-19
cardio-pulmonary bypass

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17
Q

What are clinical features of Acute respiratory distress syndrome (ARDS) ?

A

dyspnoea
elevated respiratory rate
bilateral lung crackles
low oxygen saturations

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18
Q

What is the criteria for Acute respiratory distress syndrome (ARDS) ?

A

Criteria (American-European Consensus Conference)
acute onset (within 1 week of a known risk factor)
pulmonary oedema: bilateral infiltrates on chest x-ray (‘not fully explained by effusions, lobar/lung collapse or nodules)
non-cardiogenic (pulmonary artery wedge pressure needed if doubt)
pO2/FiO2 < 40kPa (300 mmHg)

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19
Q

What are they key investigations for Acute respiratory distress syndrome (ARDS) ?

A

A chest x-ray and arterial blood gases are the key investigations.

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20
Q

What is the management for Acute respiratory distress syndrome (ARDS) ?

A

due to the severity of the condition patients are generally managed in ITU
oxygenation/ventilation to treat the hypoxaemia
general organ support e.g. vasopressors as needed
treatment of the underlying cause e.g. antibiotics for sepsis
certain strategies such as prone positioning and muscle relaxation have been shown to improve outcome in ARDS

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21
Q

Acute respiratory distress syndrome can only be diagnosed in the absence of…

A

of a cardiac cause for pulmonary oedema (i.e. the pulmonary capillary wedge pressure must not be raised)

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22
Q

What is pulmonary wedge pressure?

A

Pulmonary Capillary Wedge Pressure (PCWP) is a measurement that tells us about the pressure in the left side of the heart, especially the left atrium.

left ventricular end diastolic pressure

Why is it important?

It helps diagnose causes of pulmonary edema (fluid in the lungs).
If PCWP is high (>18 mmHg), it suggests that the heart (especially the left side) is failing to pump blood forward properly (e.g., in heart failure).
If PCWP is normal or low, but the patient still has lung problems (like in ARDS), it suggests the issue isn’t from heart failure but from lung damage itself.
Quick summary:

High PCWP → Think heart problem (like heart failure).
Normal/low PCWP → Think lung problem (like ARDS).

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23
Q

What is the most common organism causing infective exacerbations of COPD?

A

Haemophilus influenzae- most common

Streptococcus pneumoniae
Moraxella catarrhalis

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24
Q

The most common viral infective causes of COPD exacerbations are

A

respiratory viruses
account for around 30% of exacerbations
human rhinovirus is the most important pathogen

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25
What is the management of exacerbation of COPD?
ncrease the frequency of bronchodilator use and consider giving via a nebuliser give prednisolone 30 mg daily for 5 days it is common practice for all patients with an exacerbation of COPD to receive antibiotics. NICE do not support this approach. They recommend giving oral antibiotics 'if sputum is purulent or there are clinical signs of pneumonia' the BNF recommends one of the following oral antibiotics first-line: amoxicillin or clarithromycin or doxycycline.
26
Admission is recommended in exacerbation of COPD if any of the following criteria are met...
severe breathlessness acute confusion or impaired consciousness cyanosis oxygen saturation less than 90% on pulse oximetry. social reasons e.g. inability to cope at home (or living alone) significant comorbidity (such as cardiac disease or insulin-dependent diabetes)
27
How to manage Severe exacerbations of COPD requiring secondary care
Oxygen therapy COPD patients are at risk of hypercapnia - therefore an initial oxygen saturation target of 88-92% should be used prior to the availability of blood gases, use a 28% Venturi mask at 4 l/min and aim for an oxygen saturation of 88-92% for patients with risk factors for hypercapnia but no prior history of respiratory acidosis adjust target range to 94-98% if the pCO2 is normal Nebulised bronchodilator beta adrenergic agonist: e.g. salbutamol muscarinic antagonists: e.g. ipratropium Steroid therapy as above IV hydrocortisone may sometimes be considered instead of oral prednisolone IV theophylline may be considered for patients not responding to nebulised bronchodilators Patients with COPD are prone to develop type 2 respiratory failure. If this develops then non-invasive ventilation may be used typically used for COPD with respiratory acidosis pH 7.25-7.35 the BTS guidelines state that NIV can be used in patients who are more acidotic (i.e. pH < 7.25) but that a greater degree of monitoring is required (e.g. HDU) and a lower threshold for intubation and ventilation should be used bilevel positive airway pressure (BiPaP) is typically used with initial settings: Expiratory Positive Airway Pressure (EPAP): 4-5 cm H2O Inspiratory Positive Airway Pressure (IPAP): RCP advocate 10 cm H20 whilst BTS suggest 12-15 cm H2O
28
What is the primary care CRB65 score criteria?
NICE recommends that patients should initially be assessed in primary care using the CRB65 criteria: Criterion Marker C Confusion (abbreviated mental test score <= 8/10) R Respiration rate >= 30/min B Blood pressure: systolic <= 90 mmHg and/or diastolic <= 60 mmHg 65 Aged >= 65 years Patients are stratified for risk of death as follows: 0: low risk (less than 1% mortality risk) NICE recommend that treatment at home should be considered (alongside clinical judgement) 1 or 2: intermediate risk (1-10% mortality risk) NICE recommend that ' hospital assessment should be considered (particularly for people with a score of 2)' 3 or 4: high risk (more than 10% mortality risk) NICE recommend urgent admission to hospital
29
What is the point-of-care CRP test criteria for pneumonia?
This is currently not widely available but they make the following recommendation with reference to the use of antibiotic therapy: CRP < 20 mg/L - do not routinely offer antibiotic therapy CRP 20 - 100 mg/L - consider a delayed antibiotic prescription CRP > 100 mg/L - offer antibiotic therapy
30
What is the secondary care CURB65 score criteria?
Criterion Marker C Confusion (abbreviated mental test score <= 8/10) U urea > 7 mmol/L R Respiration rate >= 30/min B Blood pressure: systolic <= 90 mmHg and/or diastolic <= 60 mmHg 65 Aged >= 65 years NICE recommend, in conjunction with clinical judgement: consider home-based care for patients with a CURB65 score of 0 or 1 - low risk (less than 3% mortality risk) consider hospital-based care for patients with a CURB65 score of 2 or more - intermediate risk (3-15% mortality risk) consider intensive care assessment for patients with a CURB65 score of 3 or more - high risk (more than 15% mortality risk)
31
What are investigations for pneumonia?
chest x-ray in intermediate or high-risk patients NICE recommend blood and sputum cultures, pneumococcal and legionella urinary antigen tests CRP monitoring is recommend for admitted patients to help determine response to treatment
32
What is the management of low-severity community acquired pneumonia?
amoxicillin is first-line if penicillin allergic then use a macrolide e.g Clarithromycin or tetracycline eg doxycycline NICE now recommend a 5 day course of antibiotics for patients with low severity community acquired pneumonia
33
What is the management of moderate and high-severity community acquired pneumonia?
dual antibiotic therapy is recommended with amoxicillin and a macrolide a 7-10 day course is recommended NICE recommend considering a beta-lactamase stable penicillin such as co-amoxiclav, ceftriaxone or piperacillin with tazobactam and a macrolide in high-severity community acquired pneumonia
34
What is the Discharge criteria for pneumonia?
NICE recommend that patients are not routinely discharged if in the past 24 hours they have had 2 or more of the following findings: temperature higher than 37.5°C respiratory rate 24 breaths per minute or more heart rate over 100 beats per minute systolic blood pressure 90 mmHg or less oxygen saturation under 90% on room air abnormal mental status inability to eat without assistance. They also recommend delaying discharge if the temperature is higher than 37.5°C.
35
What advice should be given to patients with pneumonia in terms of how quickly their symptoms should symptoms should resolve?
NICE recommend that the following information is given to patients with pneumonia in terms of how quickly their symptoms should symptoms should resolve: Time Progress 1 week Fever should have resolved 4 weeks Chest pain and sputum production should have substantially reduced 6 weeks Cough and breathlessness should have substantially reduced 3 months Most symptoms should have resolved but fatigue may still be present 6 months Most people will feel back to normal.
36
All cases of pneumonia should have a repeat chest X-ray at ...
6 weeks after clinical resolution to ensure that the consolidation has resolved and there is no underlying secondary abnormalities (e.g. a lung tumour).
37
Parotid gland involvement occurs in approximately 6% of patients with sarcoidosis and is part of a triad known as
Heerfordt's syndrome (uveoparotid fever), which includes parotid enlargement, uveitis, and facial nerve palsy.
38
What finding on a blood test would support lung cancer?
Raised platelets
39
What are the Investigations of suspected asthma in adults
First-line investigations NICE measure the eosinophil count OR fractional nitric oxide (FeNO) diagnose asthma, without further investigations, if: eosinophil is above the reference range FeNO is ≥ 50 ppb If asthma is not confirmed by the eosinophil count or FeNO measure bronchodilator reversibility (BDR) with spirometry diagnose asthma if: the FEV1 increase is ≥ 12% and 200 ml or more from the pre-bronchodilator measurement, or the FEV1 increase is ≥ 10% of the predicted normal FEV1 if spirometry is not available or it is delayed, measure peak expiratory flow (PEF) twice daily for 2 weeks diagnose asthma if: PEF variability (expressed as amplitude percentage mean) is ≥ 20% If asthma is not confirmed by eosinophil count, FeNO, BDR or PEF variability but still suspected on clinical grounds: refer for consideration of a bronchial challenge test diagnose asthma if bronchial hyper-responsiveness is present
40
What are the Investigations of suspected asthma in children aged 5 to 16
First-line investigation NICE measure the fractional nitric oxide (FeNO) diagnose asthma if: FeNO is ≥ 35 ppb If the FeNO level is not raised, or if FeNO testing is not available: measure bronchodilator reversibility (BDR) with spirometry diagnose asthma if: the FEV1 increase is ≥ 12% from the pre-bronchodilator measurement, or the FEV1 increase is ≥ 10% of the predicted normal FEV1 if spirometry is not available or it is delayed, measure peak expiratory flow (PEF) twice daily for 2 weeks diagnose asthma if: PEF variability (expressed as amplitude percentage mean) is ≥ 20% If asthma is not confirmed by FeNO, BDR or PEF variability but still suspected on clinical grounds: perform skin prick testing to house dust mite OR measure total IgE level and blood eosinophil count exclude asthma if there is no evidence of sensitisation to house dust mite on skin prick testing OR if the total serum IgE is not raised diagnose asthma if there is evidence of sensitisation OR a raised total IgE level and the eosinophil count is > 0.5 x 109/L If there is still doubt about the diagnosis refer to a paediatric specialist for a second opinion, including consideration of a bronchial challenge test
41
What are the Investigations of suspected asthma in children aged under 5?
The guidelines acknowledge the difficulty of performing tests in such young children. They suggest: NICE treating with inhaled corticosteroids as per the management guidelines with regular review if they still have symptoms at age 5 then attempt objective tests refer to a specialist respiratory paediatrician any preschool child with an admission to hospital, or 2 or more admissions to an emergency department, with wheeze in a 12-month period.
42
What are the key indications for NIV?
NIV should be considered in all patients with an acute exacerbation of COPD in whom a respiratory acidosis (PaCO2>6kPa, pH <7.35 ≥7.26) persists despite immediate maximum standard medical treatment COPD with respiratory acidosis pH 7.25-7.35 the BTS guidelines state that NIV can be used in patients who are more acidotic (i.e. pH < 7.25) but that a greater degree of monitoring is required (e.g. HDU) and a lower threshold for intubation and ventilation should be used type II respiratory failure secondary to chest wall deformity, neuromuscular disease or obstructive sleep apnoea cardiogenic pulmonary oedema unresponsive to CPAP weaning from tracheal intubation
43
Recommended initial settings for bi-level pressure support in COPD
Expiratory Positive Airway Pressure (EPAP): 4-5 cm H2O Inspiratory Positive Airway Pressure (IPAP): RCP advocate 10 cm H20 whilst BTS suggest 12-15 cm H2O back up rate: 15 breaths/min back up inspiration:expiration ratio: 1:3
44
What is the management for occupational asthma?
Serial measurements of peak expiratory flow are recommended at work and away from work. Referral should be made to a respiratory specialist for patients with suspected occupational asthma.
45
Exposure to the following chemicals is associated with occupational asthma:
isocyanates - the most common cause example occupations include spray painting and foam moulding using adhesives platinum salts soldering flux resin glutaraldehyde flour epoxy resins proteolytic enzymes
46
What are the features of small cell lung cancer?
usually central arise from APUD* cells associated with ectopic ADH, ACTH secretion ADH → hyponatraemia ACTH → Cushing's syndrome ACTH secretion can cause bilateral adrenal hyperplasia, the high levels of cortisol can lead to hypokalaemic alkalosis Lambert-Eaton syndrome: antibodies to voltage gated calcium channels causing myasthenic like syndrome
47
Risk factors for the development of aspiration pneumonia include:
Poor dental hygiene Swallowing difficulties Prolonged hospitalization or surgical procedures Impaired consciousness Impaired mucociliary clearance
48
What are the most common sites affected in aspiration pneumonia?
The right middle and lower lung lobes are the most common sites affected, due to the larger calibre and more vertical orientation of the right main bronchus.
49
The bacteria implicated in aspiration pneumonia may be aerobic or anaerobic. Examples of aerobic bacteria include:
Streptococcus pneumoniae Staphylococcus aureus Haemophilus influenzae Pseudomonas aeruginosa Klebsiella: often seen in aspiration lobar pneumonia in alcoholics
50
The bacteria implicated in aspiration pneumonia may be aerobic or anaerobic. Examples of anaerobic bacteria include:
Bacteroides Prevotella Fusobacterium Peptostreptococcus
51
Management of pneumothhorax
The first step is assessing whether the patient is symptomatic the BTS define minimal symptoms as 'no significant pain or breathlessness and no physiological compromise' no or minimal symptoms → conservative care, regardless of pneumothorax size symptomatic → assess for high-risk characteristics If a pneumothorax is symptomatic, the next step is assessment for high-risk characteristics high-risk characteristics are defined as follows: haemodynamic compromise (suggesting a tension pneumothorax) significant hypoxia bilateral pneumothorax underlying lung disease ≥ 50 years of age with significant smoking history haemothorax if no high-risk characteristics are present, and it is safe to intervene, then there is a choice of intervention: conservative care ambulatory device needle aspiration if high-risk characteristics are present, and it is safe to intervene → chest drain How is safety or intervention determined? before a needle aspiration/chest drain insertion, the safety of intervention should be assessed this depends on the clinical context, but is usually: 2cm laterally or apically on chest x-ray, or any size on CT scan which can be safely accessed with radiological support Management options Conservative care patients with a primary spontaneous pneumothorax that is managed conservatively should be reviewed every 2-4 days as an outpatient patients with a secondary spontaneous pneumothorax that is managed conservatively should be monitored as an inpatient if stable, follow-up in the outpatients department in 2-4 weeks Needle aspiration a chest drain should be inserted if needle aspiration of a pneumothorax is unsuccessful if resolved, discharge and follow-up in the outpatients department in 2-4 weeks Chest drain insertion daily review as an inpatient remove drain when resolved discharge and follow-up in the outpatients department in 2-4 weeks
52
Management of Persistentent / recurrent pneumothorax
If a patient has a persistent air leak or insufficient lung reexpansion despite chest drain insertion, or the patient has recurrent pneumothoraces, then video-assisted thoracoscopic surgery (VATS) should be considered to allow for mechanical/chemical pleurodesis +/- bullectomy.
53
Discharge advice post pneumpthorax
Smoking patients should be advised to avoid smoking to reduce the risk of further episodes - the lifetime risk of developing a pneumothorax in healthy smoking men is around 10% compared with around 0.1% in non-smoking men Fitness to fly absolute contraindication, the CAA suggest patients may travel 2 weeks after successful drainage if there is no residual air. The British Thoracic Society used to recommend not travelling by air for a period of 6 weeks but this has now been changed to 1 week post check x-ray Scuba diving the BTS guidelines state: 'Diving should be permanently avoided unless the patient has undergone bilateral surgical pleurectomy and has normal lung function and chest CT scan postoperatively.'
54
What is recommended in COPD patients who meet certain criteria and who continue to have exacerbations
Azithromycin prophylaxis
55
What is criteria for oral antibiotic prophylaxis in COPD patients?
patients should not smoke, have optimised standard treatments and continue to have exacerbations other prerequisites include a CT thorax (to exclude bronchiectasis) and sputum culture (to exclude atypical infections and tuberculosis) LFTs and an ECG to exclude QT prolongation should also be done as azithromycin can prolong the QT interval
56
COPD stable management
General management >smoking cessation advice: including offering nicotine replacement therapy, varenicline or bupropion annual influenza vaccination one-off pneumococcal vaccination pulmonary rehabilitation to all people who view themselves as functionally disabled by COPD (usually Medical Research Council [MRC] grade 3 and above) Bronchodilator therapy a short-acting beta2-agonist (SABA) or short-acting muscarinic antagonist (SAMA) is first-line treatment for patients who remain breathless or have exacerbations despite using short-acting bronchodilators the next step is determined by whether the patient has 'asthmatic features/features suggesting steroid responsiveness' There are a number of criteria NICE suggest to determine whether a patient has asthmatic/steroid responsive features: any previous, secure diagnosis of asthma or of atopy a higher blood eosinophil count - note that NICE recommend a full blood count for all patients as part of the work-up substantial variation in FEV1 over time (at least 400 ml) substantial diurnal variation in peak expiratory flow (at least 20%) No asthmatic features/features suggesting steroid responsiveness add a long-acting beta2-agonist (LABA) + long-acting muscarinic antagonist (LAMA) if already taking a SAMA, discontinue and switch to a SABA Asthmatic features/features suggesting steroid responsiveness LABA + inhaled corticosteroid (ICS) if patients remain breathless or have exacerbations offer triple therapy i.e. LAMA + LABA + ICS if already taking a SAMA, discontinue and switch to a SABA NICE recommend the use of combined inhalers where possible Oral theophylline NICE only recommends theophylline after trials of short and long-acting bronchodilators or to people who cannot used inhaled therapy the dose should be reduced if macrolide or fluoroquinolone antibiotics are co-prescribed
57
COPD Standby medication: NICE recommend offering a short course of oral corticosteroids and oral antibiotics to keep at home if:
have had an exacerbation within the last year understand how to take the medication, and are aware of associated risks and benefits know to when to seek help and when to ask for replacements once medication has been used
58
Factors which may improve survival in patients with stable COPD
smoking cessation - the single most important intervention in patients who are still smoking long term oxygen therapy in patients who fit criteria lung volume reduction surgery in selected patients
59
Features and management of cor pulmonale?
features include peripheral oedema, raised jugular venous pressure, systolic parasternal heave, loud P2 use a loop diuretic for oedema, consider long-term oxygen therapy ACE-inhibitors, calcium channel blockers and alpha blockers are not recommended by NICE
60
When are Phosphodiesterase-4 (PDE-4) inhibitors recomended in COPD?
oral PDE-4 inhibitors such as roflumilast reduce the risk of COPD exacerbations in patients with severe COPD and a history of frequent COPD exacerbations NICE recommend if: the disease is severe, defined as a forced expiratory volume in 1 second (FEV1) after a bronchodilator of less than 50% of predicted normal, and the person has had 2 or more exacerbations in the previous 12 months despite triple inhaled therapy with a long-acting muscarinic antagonist, a long-acting beta-2 agonist and an inhaled corticosteroid
61
When should mucolytics be considered in COPD?
should be 'considered' in patients with a chronic productive cough and continued if symptoms improve
62
Causes of a raised TLCO
asthma pulmonary haemorrhage (e.g. granulomatosis with polyangiitis, Goodpasture's) left-to-right cardiac shunts polycythaemia hyperkinetic states male gender, exercise More blood, more hemoglobin, more surface area = higher TLCO
63
Causes of a lower TLCO
pulmonary fibrosis pneumonia pulmonary emboli pulmonary oedema emphysema anaemia low cardiac output
64
KCO also tends to increase with age. Some conditions may cause an increased KCO with a normal or reduced TLCO
Quick way to remember: KCO = gas transfer efficiency per lung volume. TLCO = total gas transfer across all lungs. 📈 High KCO can happen when: Lungs are smaller but functioning very well (e.g., lung collapse, lobectomy) — "what lung is left is working overtime." Pulmonary hemorrhage (lots of hemoglobin around, even if lung size is normal) 📉 Low KCO can happen when: Lung tissue is damaged (e.g., emphysema — destroyed alveoli and capillaries) Severe pulmonary fibrosis Sometimes the TLCO might be low just because the lung size is small (e.g., after lung surgery or collapse), not because the lung tissue itself is bad. KCO helps separate whether the issue is small lung size or poor gas exchange. pneumonectomy/lobectomy scoliosis/kyphosis neuromuscular weakness ankylosis of costovertebral joints e.g. ankylosing spondylitis
65
What picture is alpha 1 antitrypsin on spirometry?
obstructive
66
What is the management of alpha 1 anti tripsin deficiency?
no smoking supportive: bronchodilators, physiotherapy intravenous alpha1-antitrypsin protein concentrates surgery: lung volume reduction surgery, lung transplantation
67
Features of alpha 1 anti tripsin deficiency?
patients who manifest disease usually have PiZZ genotype lungs: panacinar emphysema, most marked in lower lobes liver: cirrhosis and hepatocellular carcinoma in adults, cholestasis in children
68
Obstructive lung disease
FEV1 - significantly reduced FVC - reduced or normal FEV1% (FEV1/FVC) - reduced Asthma COPD Bronchiectasis Bronchiolitis obliterans
69
Restrictive lung disease
FEV1 - reduced FVC - significantly reduced FEV1% (FEV1/FVC) - normal or increased Pulmonary fibrosis Asbestosis Sarcoidosis Acute respiratory distress syndrome Infant respiratory distress syndrome Kyphoscoliosis e.g. ankylosing spondylitis Neuromuscular disorders Severe obesity
70
Acute asthma management
Management admission all patients with life-threatening should be admitted in hospital patients with features of severe acute asthma should also be admitted if they fail to respond to initial treatment. other admission criteria include a previous near-fatal asthma attack, pregnancy, an attack occurring despite already using oral corticosteroid and presentation at night oxygen if patients are hypoxaemic, it is important to start them on supplemental oxygen therapy if patients are acutely unwell they should be started on 15L of supplemental via a non-rebreathe mask, which can then be titrated down to a flow rate where they are able to maintain a SpO‚‚ 94-98%. bronchodilation with short-acting beta‚‚-agonists (SABA) high-dose inhaled SABA e.g. salbutamol, terbutaline in patients without features of life-threatening or near-fatal asthma, this can be given by a standard pressurised metered-dose inhaler (pMDI) or by an oxygen-driven nebulizer in patients with features of a life-threatening exacerbation of asthma, nebulised SABA is recommended corticosteroid all patients should be given 40-50mg of prednisolone orally (PO) daily, which should be continued for at least five days or until the patient recovers from the attack during this time, patients should continue their normal medication routine including inhaled corticosteroids. ipratropium bromide: in patients with severe or life-threatening asthma, or in patients who have not responded to beta‚‚-agonist and corticosteroid treatment, nebulised ipratropium bromide, a short-acting muscarinic antagonist IV magnesium sulphate the BTS notes that the evidence base is mixed for this treatment that is now commonly given for severe/life-threatening asthma IV aminophylline may be considered following consultation with senior medical staff patients who fail to respond require senior critical care support and should be treated in an appropriate ITU/HDU setting. Treatment options include: intubation and ventilation extracorporeal membrane oxygenation (ECMO)
71
What is the Criteria for discharge for acute asthma attack?
been stable on their discharge medication (i.e. no nebulisers or oxygen) for 12-24 hours inhaler technique checked and recorded PEF >75% of best or predicted
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Accounts for 80% of cases Particularly associated with high fever, rapid onset and herpes labialis
Streptococcus pneumoniae (pneumococcus)
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Often occurs in patient following influenza infection what is the causative organism of pneumonia?
Staphylococcus aureus
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One of the atypical pneumonias, which often present a dry cough and atypical chest signs/x-ray findings Autoimmune haemolytic anaemia and erythema multiforme may be seen causative organism of pneumonia?
Mycoplasma pneumoniae
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Another one of the atypical pneumonias Hyponatraemia and lymphopenia common Classically seen secondary to infected air conditioning units causative organism of pneumonia?
Legionella pneumophilia
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Classically seen in alcoholics causative organism of pneumonia?
Klebsiella pneumoniae
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Typically seen in patients with HIV Presents with a dry cough, exercise-induced desaturations and the absence of chest signs causative organism of pneumonia?
Pneumocystis jiroveci
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Idiopathic interstitial pneumonia
is a group of non-infective causes of pneumonia. Examples include cryptogenic organizing pneumonia which describes a form of bronchiolitis that may develop as a complication of rheumatoid arthritis or amiodarone therapy.
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Allergic bronchopulmonary aspergillosis
Allergic bronchopulmonary aspergillosis results from an allergy to Aspergillus spores. In the exam questions often give a history of bronchiectasis and eosinophilia.
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What investigations for Allergic bronchopulmonary aspergillosis?
eosinophilia flitting CXR changes positive radioallergosorbent (RAST) test to Aspergillus positive IgG precipitins (not as positive as in aspergilloma) raised IgE
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What is the management for Allergic bronchopulmonary aspergillosis??
oral glucocorticoids itraconazole is sometimes introduced as a second-line agent
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What are the features of Allergic bronchopulmonary aspergillosis??
bronchoconstriction: wheeze, cough, dyspnoea. Patients may have a previous label of asthma bronchiectasis (proximal)
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Whilst mesothelioma is in some ways synonymous with asbestos, lung cancer is actually the most common form of cancer associated with asbestos exposure.
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What is Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)?
Eosinophilic Granulomatosis with Polyangiitis (EGPA)—formerly called Churg-Strauss syndrome—is a rare form of ANCA-associated vasculitis that affects small- to medium-sized blood vessels, with eosinophilic infiltration and granuloma formation.
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What are the three phases of Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)?
Key Characteristics Triad: Asthma Eosinophilia Systemic vasculitis It classically progresses in three phases: Allergic phase – asthma, allergic rhinitis, sinusitis. Eosinophilic phase – marked peripheral eosinophilia, eosinophilic infiltration of lungs and GI tract. Vasculitic phase – systemic necrotizing vasculitis affecting multiple organs (esp. nerves, skin, kidneys). Features asthma blood eosinophilia (e.g. > 10%) paranasal sinusitis mononeuritis multiplex renal involvement occurs in around 20% pANCA positive in 60%
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A positive ANCA (anti-neutrophil cytoplasmic antibody)
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
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What amay precipitate Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)?
Leukotriene receptor antagonists may precipitate the disease.
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Features of Klebsiella pneumonia
more common in alcoholic and diabetics may occur following aspiration 'red-currant jelly' sputum often affects upper lobes Prognosis commonly causes lung abscess formation and empyema mortality is 30-50% A chest X-ray is carried out which shows bilateral cavitating opacities in the upper lobe.
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Pseudomonas aeruginosa
Pseudomonas aeruginosa is a common pathogen in bronchiectasis and cystic fibrosis. It is a common cause of hospital-acquired pneumonia, especially in those patients in the ITU on a ventilator. It doesn't cause the X-ray changes seen in this scenario. Instead, 'ground-glass' attenuation can often be noticed on a CT scan.
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Mycoplasma pneumoniae
Mycoplasma pneumoniae causes flu-like symptoms such as a headache, arthralgia and myalgia followed by a dry cough which are not seen in this case. Chest X-ray often shows patchy consolidation of one lower lobe.
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Legionella pneumophilia
Legionella pneumophilia also causes flu-like symptoms such as fever, myalgia. It can also cause extra-pulmonary symptoms such as hepatitis, diarrhea and vomiting. Bi-basal consolidation can be seen on chest X-ray.
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Staphylococcus aureus
Staphylococcus aureus is often seen in intravenous drug users (IVDU), young, elderly or people with an underlying disease such as leukemia or cystic fibrosis. The patient's history of alcoholism points more towards Klebsiella
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Renal cell carcinoma can metastasise to the lungs, causing 'cannonball metastases' although they can also be seen with other malignancies such as choriocarcinoma or endometrial cancer.
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Azithromycin prophylaxis is recommended in COPD patients who meet certain criteria and who continue to have exacerbations:
NICE guidelines suggest a prescription of 250mg azithromycin three times per week if: The patient no longer smokes. Has optimised non-pharmacological management & inhaled therapies. Referred to pulmonary rehab (if appropriate). 4 acute exacerbations in the last year (producing sputum), requiring hospital admission at least once.
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Steps to determine correct Nasogastric tube insertion
Nasogastric tubes are safe to use if pH <5.5 on aspirate If aspirate >5.5, request a chest x-ray to confirm the position of the NG tube. If no aspirate can be obtained, the following manoeuvres can be used: Turn the patient on to their left side Inject 10-20ml air Offer a drink (if safe swallow) or mouth care (if nil by mouth) and re-check aspirate in 15-20 minutes Advance or withdraw the NG tube by 10-20 cm If an aspirate can still not be obtained, request a chest x-ray to confirm the position of the NG tube.
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Steroids are only indicated in patients with stage 2/3 disease who are symptomatic, have hypercalcaemia, or who have heart, eye, or neuro involvement. As this patient has none of these features, treatment is not indicated.
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A chest x-ray may show the following changes in sarcoidosis: stage 0 = normal stage 1 = bilateral hilar lymphadenopathy (BHL) stage 2 = BHL + interstitial infiltrates stage 3 = diffuse interstitial infiltrates only stage 4 = diffuse fibrosis
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Bupropion should not be used in a patient with epilepsy as it reduces seizure threshold
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Insertion of a chest drain is relatively contraindicated in patients with any of the following:
INR > 1.3 Platelet count < 75 Pulmonary bullae Pleural adhesions Please note, all of the above represent only relative contraindications, addressing respiratory compromise in an emergency situation should always be on an individual case basis.
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Complications that may occur and which the patient should be advised of in the process of obtaining consent:
Failure of insertion - the drain may be abutting the apical pleura, in which case it should be pulled back, or may be subcutaneous or in rare cases could enter the abdominal cavity. In both latter cases, the drain should be removed and re-sited. Bleeding - around the site of the drain or into the pleural space Infection Penetration of the lung Re-expansion pulmonary oedema Re-expansion pulmonary oedema may be preceded by the onset of a cough and/or shortness of breath. In the event of concerns regarding re-expansion pulmonary oedema, the chest drain should be clamped and an urgent chest x-ray should be obtained. To avoid re-expansion pulmonary oedema, it is recommended that the drain tubing should be clamped regularly in the event of rapid fluid output i.e. drain output should not exceed 1L of fluid over a short period of time (less than 6 hours).
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Removal of the chest drain is dependent upon the indication for insertion:
In cases of fluid drainage from the pleural cavity, the drain should be removed when there has been no output for > 24 hours and imaging shows resolution of the fluid collection. In cases of pneumothorax, the drain should be removed when it is no longer bubbling spontaneously or when the patient coughs and ideally when imaging shows resolution of the pneumothorax. Drains inserted in cases of penetrating chest injury should be reviewed by the specialist to confirm an appropriate time for removal.