Respiratory Flashcards

(96 cards)

1
Q

Define Asthma

A

Chronic inflammation disease of the lung airways characterised by reversible airflow obstruction and bronchospasm?

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2
Q

What are the 3 defining features of asthma?

A

Reversible airflow limitation
Airway hyper-responsiveness
Bronchial inflammation

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3
Q

Who gets/has asthma?

A

2 peaks

  1. 5-15 (more males than females)
  2. 55-64 (more females than males)
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4
Q

Difference between atopic asthma and non atopic?

A

Non atopic - causative organism found - often starts middle age but often Hx resp illness
Atopic - no causative organism found. Frequent in allergic individuals

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5
Q

What is the allergic triad?

A

Asthma
Eczema
Rhinitis (hayfever)

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6
Q

What are the biological causes of asthma? (3)

A

Atopic - circulating allergen specific IgE
Genetic- no specific gene but several seem to play a part in development avec environment
Environment - allergen exposure, maternal smoking, viruses, hygeine

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7
Q

What are the triggers of asthma? (7)

A
Cold air
Exercise 
Emotion
Drugs - NSAIDs, Asthma
Allergens
Irritants
Viruses - HSV,RSV, Parainfluenza
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8
Q

What is the pathophysiology process of asthma?

1. IgE hypersensitivity reaction casusing…

A
  1. Bronchoconstriction
  2. Inflammation - caused my mast cells, eoisinphils, dendritic cells, lymphocytes
  3. Increased mucous production
  4. Airway remodelling
    - loss cilliated columnar cells due to epithelial damage
    - thickened basement membrane due to deposition repair collagens
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9
Q

Symptoms of asthma?

A
Wheeze
Nocturnal dysnoea
COugh (normally noctunal)
Chest tightness
SOB
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10
Q

Signs of asthma?

A

Hyperinfaltion, hyper resonance
Wheeze
decrease ae
Tacypnoeic

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11
Q

What are features of severe acute asthma?

A

HR >110, RR >25, PEFR 33-55%, Cant speak full sentences

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12
Q

What are the features of life threatening asthma?

A

PEFR <33%, o2 sats <92%

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13
Q

What are the features of near fatal asthma?

A

paCO2 >6kpa

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14
Q

DDX of asthma include?

A
Pulmonary Oedema
COPD
Pneumothorax
Bronchiectasis
SVC obstruction
Large airway obstruction
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15
Q

IX asthma?

A

Peak flow - monitor and management
Spirometry - if FEV1 increases after bronchodilator = asthma
X ray - rule out other problems
(exercise testing, prednisiloen trial)

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16
Q

Treatment of asthma?

A
Salbutamol
Budesonide
Salmeterol
(adding up each time)
Severe uncontrolled symtoms = high does corticosteroids, long term b2 agonist, +LRTA/theophyline
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17
Q

Define COPD

A

Progressive disease that includes chronic bronchitis and emphysema

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18
Q

What is chronic Bronchitis?

A

Chronic bronchitis is a cough with sputum production on most days for 3 months for 2 years

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19
Q

What is Emphysema?

A

Enlarged air spaces distal to terminal bronchioles due to destruction of alveoli walls

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20
Q

Centri - acinar emphysema?

A

Most common

damage around bronchioles but bronchioles not actually involved

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21
Q

Pan acinar emphysema?

A

whole acinus destruction

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22
Q

Irregular emphysema?

A

patchy

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23
Q

What does emphysema result in? (2)

A

Air trapping and increase TLC due to loss of elastic recoil

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24
Q

3 mechanisms to COPD limiation of airflow

A
  1. Loss elastic recoil
    Reduced recoid causes airways to collapse during expiration.
    LEss alveoli means less gas exchange can occur
  2. increase mucous - increase goblet cells in bronchial mucosa
  3. inflammation
    epithelial cells get damaged and ulcerated - cuboidal cells get replaced with squamous cells
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25
Risk factors of COPD? (4)
Smoking 90% A1 trypsin deficiency Age air pollution/occupational dusst
26
What are the symptoms of copd? (5)
``` SOB Chronic Cough Chest pain Wheeze Recurrent chest infections ```
27
What are the signs of COPD?
``` Hyperinflation, hyperresonant tachypnoeic accessory muscles pursed lip breathing Co2 flap/ cyanosis if severe ```
28
Some of the ddx COPD?
``` Asthma Pneumonia Lung cancer Bronchiectasis TV CHF ```
29
IX of COPD?
``` CXR - flattened hemidiaphragms and hyperinflation Spirometry ABG FBC - polycythaemia ECG - cor pulmonale ```
30
Treatment of COPD?
Salbutamol, Ipatropium Bromide Salmeterol, Tiotropium bromide (longer acting) Inhaled steroids Oral steroids Mucolytics for chronic cough eg carbocysteine Doxycycline for acute exacerbatins (infections)
31
What is a pneumothorax?
Air in pleura resulting in lung collapse on the affected side?
32
What are the 3 different types of pneumothorax?
primary sponty secondary sponty tension
33
What is cause of primary sponty?
Sponty rupture of a sub plural bullae
34
Causes of secondary sponty?
These are caused by underlying lung conditiosn including: Asthma, COPD, TB, CF
35
Causes of tension pneumothorax?
Trauma and creation of the one way valve. MEDICAL EMERGENCY
36
Risk factors for spontaneous pneumothorax?
``` White, blonde, skinny, tall Lung disease Marfans Smoking Fam hx ```
37
Symptoms of pneumothorax?
Acute pluritic chest pain SOB Dyspnoea
38
Signs of pneumothorax?
``` small can = asymptomatic Hyperesonant unilateral Decrease voacal resonance Decrease ae tenstion - Tracheal deviation away, HR up ```
39
Ix of pneumothorax?
Chest x ray but dont wait if think tension.
40
Treatement of tension pneumothorax?
2nd intercostal space wide bore cannula mid clavicular line
41
Treatment of sponty pneumothorax?
Insertion of chest drain in safe triangle (cba to learn borders)
42
Prognosis of pneumothorax?
Good but recurrence high 54 %
43
What are the two main categories of bronchial carcinoma?
Small-cell | Non-small cell
44
What are the features of small-cell carcinoma?
Also called out cell carcinoma Highly malignant and often inoperable the presentation Originate from kulchitsky cells
45
What percentage do non-small cell lung carcinoma is account for?
85%
46
What are the features of squamous cell lung carcinoma?
Arise from epithelium cells Cause obstructive lesions of the bronchus Local spread common metastasises late
47
What are the features of lung adenocarcinoma?
Increased risk smokers Arise from mucus cells in Bronchus epithelium Often metastasised to brain and bone
48
What are the features of large cell lung carcinoma?
Just less differentiated types of large cell and squamous cell
49
What are carcinoid lung tumours?
Slow growing neuroendocrine tumour | Arise from kulchitsky cells
50
What are the risk factors of lung cancer?
Smoking asbestos radiation age history of cancer
51
What are the symptoms of lung cancer?
``` Cough, haemoptysis Weight loss Chest pain Dyspnoea Lethargy ```
52
All the signs of lung cancer?
Cache is Anaemia Supraclavicular or axillary lymph adenopathy Bone/liver problems
53
What are the investigations of lung cancer?
Triple screen Chest x-ray for cancer causing symptoms Pet scan looking for mets CT looking for lymphadenopathy/spread (Bronchoscope, bloods - anemia, lft
54
What is the management of large cell lung carcinoma?
Can try chemotherapy but often palliative radio therapy and chemotherapy with analgesia
55
What is the treatment for non-small cell lung carcinoma is?
Surgical reception Radiotherapy/chemotherapy Gefitinib if EGFR TK mutation
56
What type of long tumour can cause Horners syndrome?
Pancoast tumour
57
Where does lung cancer and norms metastasise?
Brain bone liver
58
Define pneumonia?
Severe chest infection with x-ray changes and associated fever and chest symptoms
59
What are the two different types of pneumonia?
Lobar | Diffuse
60
What are the common causes of community acquired pneumonia?
Streptococcus pneumonia Haemophilia influenza Moxarella catarrhalis
61
What are the common causes of hospital acquired pneumonia?
Gram negative organisms Staphylococcus aureus Viruses
62
What is the definition of hospital-acquired Pneumonia ?
Pneumonia 48 hours after hospital admission
63
What type of pneumonia does klebsiella course?
Cavitating pneumonia
64
What are the risk factors of pneumonia (lots)?
``` Age Viral infection is Smoking Immunocompromised Hospitalised Alcohol IVD staphylococcus aureus ```
65
Symptoms of pneumonia?
``` Cough Fever/ anorexia/ rigor Shortness of breath Dyspnoea Pleuritic pain ```
66
What does curb 65 stand for?
``` Confusion Urea above seven Respect for you rate above 30 Blood pressure below 90 Age > 65 ```
67
What are the signs on examination of pneumonia?
``` Pyrexial Cyanosis Confusion Consolidation - dull, increase vocal resonance Tachycardia tachypnoeic Fine crackles if pleural effusion Hypotension ```
68
What are the differences of pneumonia?
Plural effusion Simple day Asthma Bronchiectasis
69
What are the investigations for pneumonia??
Chest x-ray - consolidation +- effusion Bloods - wcc up, crp esr cultures if think sepsis Sputum MC and s
70
What to do with the results of curb?
0-1 treat at home 2 - treat at hospital More than 3 treat in ICU ( it's outta 5)
71
What is the treatment for pneumonia?
Amoxicillin clarithromycin doxycycline co a,oxiclavTazocin
72
What makes up Tazocin?
Pipperocillin and tazobactam
73
What is bronchiectasis?
Long-term condition were weight of the long become widened and leads to build up an excess mucus and therefore increased risk of infection. Often an endpoint of various condition because airway inflammation.
74
What is the definition of a plural effusion?
Fluid in the plural space more than 500 mils to be symptomatic
75
What are the two different types of pleural effusion?
Transudate and exudate
76
What is transudate pleural effusion?
Less than 25 g/L of protein Normally due to Venus leakage Due to stuff like heart failure, pericarditis, fluid overload Can be due to hypoproteinaemia from liver problems
77
What is exudate pleural effusion?
More than 25 g/L of protein Normally due to leaky capillaries in information Can because by pneumonia TB, pe
78
What are the symptoms of plural effusion?
Often asymptomatic Dyspnoe Pleuritic chest pain
79
Signs on examination of pleural effusion?
``` Fine crackles the lung bases Stony Delph to pick us Decreased vocal resonance D crease Chest expansion If v big - tracheal deviation, mediastinal shift ```
80
Investigations for plural affusion?
X Ray- meniscus, costophrenic angles lost Water dense shadow Diagnostic aspiration Go two intercostal space above the border of effusion and suck some out
81
What is the characteristics needed for empyema?
Effusion has pH less than 7.2
82
What is the treatment for pleural effusion?
Treat underlying cause obviously Drain if symptomatic If it keeps happening do pleurodesis which is basically where are you a obliterate the pleural space
83
What is a PE?
Obstruction of a vessel within the pulmonary tree usually caused by a DVT
84
What is the biological cause?
``` Usually caused by DVT Can be caused by a different type of embolism Amniotic fluid From central line Fat from surgery Embolism from endocarditis vegetation ```
85
What is verchows triad?
Blood constituent Blood vessels Blood flow
86
What is the pathophysiological effect of a PE?
Causes a VQ miss match and there is ventilation but no perfusion therefore increase of dead space and Decrease gas exchange After a few hours lung stops producing lung surfactant and collapse ensues Pulmonary htn causes cardiovascular difficulty
87
What are the symptoms of a PE?
Pleuritic chest pain Coughing up blood Syncope Dyspnoea
88
Are the signs of PE?
``` Tachypnoea Tachycardia Hypotension Right ventricular heave Raised JVP Hypoxia Gallop pulse ```
89
Investigations for PE?
Pulmonary coronary angiogram D dimer Ultrasound to look for clots ABGECG
90
Treatment for PE?
``` Low molecular weight heparin e.g. tinzaparin Consider thrombolysis (streptokinase/alteplase) ```
91
What is the rapid treatment for PE?
ABCDE assessment 02 15L non rebreathe Invasive/non invasive ventilation if required Morphine 5mg plus anti-emetic 10mg metoclopramide IV access to Widebore cannulas Low molecular weight heparin
92
What is pulmonary fibrosis?
Fibrosis and loss of elasticities of the lungs due to lung damage
93
Only fibrosis restrictive or obstructive lung disease?
Restrictive
94
What are the four types?
Replacement due to long damage Extrinsic alveolitis due to hypersensitivity Granulomatous disease e.g. sarcoidosis Radio active exposure
95
Discuss blue bloater?
``` Cyanosed not breathless Alveoli the hypoperfused Low oxygen high CO2 Rely on hypoxia drive to breathe and keep going May develop cor pulmonary ```
96
Discuss pink puffer?
Alveoli hyperperfused Not cyanosed but breathless May progress to type 1 reps failure