Respiratory Flashcards
(38 cards)
Pulmonary compliance?
Ability of pulmonary surfactant to greatly reduce surface tension, allowing easier expansion/stretching and shrinking of alveoli during respiration and the resulting changes in pressure.
What is COPD ?
EMpysema (narrowing of small airways) + Chronic bronchitis (inflammatory condition)
REstrictive lung diseases?
Loss or restriction of complete lung expansion.
Panacinar emphysema?
A-1-antitrypsin deficiency.
Inhibits neutrophil elastase and matrix metalloproteases -> limits damage to respiratory structures.
Neutrophil elastase destroys harmful stuff for the lungs
What is the rate limiting step of O2 saturation in the lungs?
Perfusion limited.
NOT DIFFUSION LIMITED.
What are pulmonary surfactants made of?
- Lecithin+myelin
- 90% are half DPPC (Dipalmitoylphosphatidylcholine) with smaller amounts of phosphatidylglycerol.
They are amphiphilic.
Reduce surface tension.
Pulmonary compliance?
THe ability of pulmonary surfactant to greatly reduce surface tension, allowing easier expansion/stretching and shrinking of alveoli during respiration and the resulting changes in pressure.
IRDS? Infant Respirtory Distress syndrome?
-Preemies (<32wks) are in trouble.
-Respiratory system develops only partially during pregnancy and becomes fully functional only after birth. Only partially formed pulmonary surfactants.
Steroids prompt surfactant production.
What does Carbonic Anhydrase do for CO2 transport?
Increases the rate of reaction about a million fold.
Most of the CO2 carried back to the lungs is as Bi-carbs.
What is the normal blood pH?
7.35-7.45
WHat is responsible for maintaining the acid base balance?
Lungs, kidneys, blood, and even the pancreas, are responsible for maintaining proper levels of H+
What is the henderson hasselbach equation?
Ph= pka+logbase/acid.
What is the HH equation in english?
Buffers are mixtures of weak acids and their conjugate bases.
If the levels of acid and base are the same then what is the ph?
Since log of 1 is 0 then ph=pka
Acute Respiratory acidosis?
Short-term decrease in respiratory function
HYPOVENTILATION
Less CO2 exhaled build up of pCO2 which is a build up of bicarb and H which makes a build up ACID!
Chronic Respiratory Acidosis
Caused by chronic respiratory problems such as chronic obstructive pulmonary disease (COPD), interstitial lung diseases, respiratory muscle fatigue
Longer term hypoventilation increases blood pCO2 leads to higher H.
Respiratory Alkalosis ?
Acute or chronic increases in exhalation of CO2 hyperventilation/hypernea -> removes bicard and H from tissues lowers H.
Can result from
- pneumonia and fever with increased rate of breathing.
- Psychiatric
- Neuro
- Prego
- Liver
- Overusing aspiring/caffeine
- altitude.
Acid/Base compensation?
- Our body can compensate.
- TIssues take or release bicarb.
BAND 3 anion exchanger protein exchanges of chlodie for bicarb.
Obstructive lung diseases?
Airflow is impaired
Centroacinar emphysema?
Affects at end of bronchioles.
-effect of nicotine on neutrophils and neutrophil elastase enzyme.
Acute bronchitis?
-Temporary irritant.
From infective agent such as virus (90%) or bacteria or environmental irritants
-cough w/ excessive mucus resolves when irritant is eliminated
Chronic bronchitis?
Long-standing disorder diagnosed for cough productive of sputum that lasts for three months or longer per year for at least 2 years
- can lead to bronchospasms
- Smoking/environmental/occupational irritants are predominant cause of this medical condition.
Asthma?
- Chronic inflammatory condition of the bronchi.
- Intermittent and partly reversible constriction of bronchi known as bronchospasm and airway obstruction.
Inflammatory cytokines, iGe.
Eosinophils, mast cells, and cd4 cells represent predominant cell types in the inflammatory process.
LARGLY REVERSIBLE UNLIKE COPD.
Effect of Basophil Degranulation?
Blocks Beta2 receptors on bronchi smooth muscle cells.
Dilation of blood vessels in the lung and smooth muscle contraction.
Parasympathetic nerves are also stimulated which release acetylcholine.
