Respiratory Core Conditions Flashcards

1
Q

What are the different types of pneumothoraces?

A

Tension: Life threatening
Open: Defect in chest wall
Primary/Spont: No underlying pathology.
Secondary: Trauma/underlying lung disease (COPD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Who most commonly has a primary spontaneous pneumothorax?

A

Tall, thin young men due to ruptured pleural bleb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the clinical features of a tension pneumothorax

A
Pleuritic chest pain
Breathlessness
Reduced breath sounds
Hyper-resonant percussion
Tracheal deviation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the features of a tension pneumothorax on a CXR?

A

Tracheal deviation AWAY from the pneumothorax

Obvious lung collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is a tension pneumothorax life-threatening?

A

Continuing increase in volume
Due to formation of one way valve allowing air into pleural space on inspiration but not out on expiration
Causes rapid increase in intra-thoracic pressure
Reduces venous return & dec CO leading to cardiac arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How is a pneumothorax investigated?

A

Tension should be diagnosed on clinical findings NOT CXR!!
CXR
CT if uncertainty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How is a pneumothorax treated?

A

Small: <2cm resolves with conservative treatment, no strenuous exercise, reassess 2weekly until air reabsorbed
Primary: SOB & >2cm on CXR, attempt aspiration, can be repeated
Secondary: SOB & >2cm on CXR, chest pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How is a tension pneumothorax treated?

A

Large bore needle decompression 2nd intercostal space midclavicular
Chest drain: 5th intercostal space midaxillary
If at 48hours PT still remains or recurrence: Pleurectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the RFs of a pneumothorax?

A
Smoking
Marfan's
Homocystinuria
FHx
Lung disease: COPD, acute s. asthma, TB, CF
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the different types of emboli?

A

Blood
Fat
Air
Amniotic fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the pathophysiology of a PE?

A

Usually complication of VTE from another source (Calf, pelvis) that becomes dislodged and flows via the bloodstream through the R side of the heart and lodges in the pulmonary circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the signs & symptoms of a PE?

A
Pyrexia
Cyanosis
Tachypnoea &amp; SOB RR >16
Tachycardia
HypoT
Raised JVP
Pleural rub
Pleural effusion
Previous DVT signs 
Pleuritic chest pain
Cough (+/- haemoptysis)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is a PE investigated?

A
PERC score
Well's score
D-Dimer: -ve can rule out but +ve not necessarily due to PE
CXR: Exclude other causes
ECG: Mostly normal, can be sinus tachy, sometimes T-wave inversion (lead 3)
CTPA
ABG: Metabolic acidosis
ECHO: R heart strain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does a PERC Score contain?

A
Rule out PE in low risk
All factors must be -ve for a -ve PERC score. +ve factor = work up (Well's Score)
Age >50
HR >100
O2 sats on room air <95%
Unilateral leg swelling
Haemoptysis
Rx surgery/trauma
Prev PE/DVT
Exogenous OE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does the Well’s Score contain?

A
Stratify pts as low or high risk
High risk = imaging
Low risk = D-dimer
Clinically suspect DVT
PE most likely diagnosis
Tachycardia >100
Immobilisation >3days OR surgery last 4weeks
Malignancy
Haemoptysis
Hx of DVT/PE in past
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How is a PE treated?

A
LMWH: Dalteparin &amp;
Warfarin 10mg 
Stop LMWH when INR >2 but continue Warfarin
Vena Cava filter
Thrombolysis: Alteplase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What 3 factors make up Virchows triad?

A

Venostasis (Immobility, paralysis, AF, congestive HF)
Hypercoagulability (Malignancy, pregnancy, protein C&S deficiency, antithrombin deficiency)
Vessel wall inflammation (trauma, surgery, indwelling catheter)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the pathophysiology of pulmonary oedema?

A

Fluid leaks from pulmonary capillaries into lung interstitium & alveoli
Filtration of fluid exceeds capacity of lymphatics to clear the fluid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the 2 types of pulmonary oedema?

A

Cardiogenic/hydrostatic: Elevated pulmonary capillary pressure from LVHF
Non-cardiogenic: Minimal elevation of pulmonary pressure caused by altered membrane permeability- ARDS

20
Q

What are the causes of pulmonary oedema?

A

Raised pressure: CHD, ACS, valvular, PE, tamponade, dissection
Renal: AKI, CKD, RA stenosis
Iatrogenic fluid overload
High output HF: anaemia, sepsis, thyrotoxic crisis
Acute/chronic URT obstruction
Inc pulmonary capillary permeability: ARDS, altitude, radiation, emboli

21
Q

What are the signs & symptoms of pulmonary oedema?

A
Severe SOB
PND/orthopnoea
Cyanosis
Congested neck veins
Raised JVP
Basal/widespread rales/fine crackles 
O2 sats <90% room air
Cardiogenic shock: HypoT, Low CO, Oliguria
22
Q

How is pulmonary oedema investigated?

A

Bloods: LFTs, clotting, U&Es, Cardiac enzymes, brain natriuretic peptides
ABG
CXR

23
Q

How is pulmonary oedema managed?

A
O2
Nitrates/ GTN infusion
Furosemide 20-40mg IV
Opiates: Diamorphine 2.5-5g IV
CPAP, ET tubing
Ultrafiltration

Arrhythmia related: DC cardioversion
Acute HF: Furosemide, High-flow O2, VTE prophylaxis, opiates, inotropes, vasodilators

24
Q

What components make up croup?

A

Harsh barking cough
Hoarse voice
Acute inspiratory stridor

25
Q

What is the cause of croup?

A
PARAINFLUENZA
Adenovirus
RSV
Measles
Coxsackie
Rhinovirus
Echovirus
Reovirus
Influenza A&amp;B
26
Q

How is croup investigated?

A

Clinical diagnosis

ABG & CXR helpful in assessing severity

27
Q

How is croup managed?

A

O2 if sats <92% on room air
Corticosteroids: Oral Dexamethasone
Severe/life-threatening: Nebulised Adrenaline 1:1000

28
Q

What are the clinical features of croup?

A
Seal-like barking cough
Worse at night
Hoarse voice
Inspiratory stridor
Severe: Tracheal tug, struggling to breathe, drinking <50% than normal, dry nappies
29
Q

Which cells are implicated in airway inflammation?

A
Eosinophils
Mast cells
Leukotrienes
Prostaglandins
T-Lymphocytes
Macrophages
Adhesion molecules
30
Q

How can an asthma attack cause a cardiac arrest?

A
  • Mucous plugging causing asphyxia COMMONEST
  • Prolonged hypoxia = arrhythmia = cardiac arrest
  • BronchoC inc airway pressures leading to breath stacking causing inc intrathoracic pressure = pneumothorax or dec venous return = circulatory collapse
31
Q

What clinical features make asthma more likely in adults?

A
  • > 1: Wheeze, cough, tightness, difficulty breathing
  • Worse at night/early morning
  • Triggered by Aspirin/Beta-blockers
  • Occur in absence of a cold
  • FHx including atopy
  • Widespread wheeze on auscultation
  • Unexplained low FEV1/PEFR
  • Unexplained peripheral blood eosinophilia
32
Q

How is asthma investigated?

A

Clinical
Spirometry: FEV1/FVC <0.7
Reversibility trial: 400ml improvement in FEV1

33
Q

How is acute asthma treated?

A

Oxygen: Sats <94%
Salbutamol: 2.5-5mg Nebs back to back, takes 15-30mins for effect
Hydrocortisone/Pred: 100mg IV when PEFR <50% of best
Ipratropium: 500mcg Nebs, max 4hourly
Theophylline/ aminophylline infusion: 1g/1L saline usually in ICU (daily U&Es, cardiac monitor)
Magnesium Sulphate: 2g in 100mls saline IV/20mins one off dose
Escalate Care

34
Q

What are the side effects of:
Salbutamol
Ipratropium

A

S: Tremor, Tachycardia
I: Dry mouth & eyes, blurred vision, tachycardia, flushing, confusion, urinary retention

35
Q

What monitoring should be done for a patient having an asthma attack in A&E?

A
OBS
PEFT: 15-30mins after Tx
Stable: Reassess 1-2hourly
O2 sats: Goal 94-98%
Bloods: U&amp;E (for K+)
ABG: <1hour of Tx
36
Q

When can a patient having an asthma attack be discharged? Not discharged?

A

Yes: PEFR >75% 1hour post-Tx
NO: Pregnant, Night presentation, Prev ICU admission, lives alone, learning disability, psych, exacerbation despite steroid tablets

37
Q

How is the severity of an asthma attack established?

A

Mild/Mod: PEFR 50-75%
Severe: PEFR 33-50% RR >25, HR>110
Life-threatening: PEFR <33%, SpO2 <92%

38
Q

How is an exacerbation of COPD treated?

A
Oxygen
Salbutamol 2.5-5mg news
Hydrocortisone 100mg IV
Prednisolone 30mg 7-14days
Ipratropium 500mcg news
Theophylline 1g/1L saline
Abx: Doxycycline 100mg
Chest physic
Consider within 60mins of admission with persistent acidosis if Tx is unsuccessful (BiPAP)
39
Q

How is an exacerbation of COPD investigated?

A

ABG 15mins after oxygen administered
CXR: Underlying pathology
Bloods: U&E, FBC, WCC

40
Q

How are asthma & COPD differentiated by different factors

A

(ex)Smoker: COPD nearly all, asthma possible
<35: COPD rare, Asthma often
Chronic productive cough: COPD common, asthma uncommon
SOB: COPD persistent & progressive, asthma variable
Night waking w/SOB: COPD uncommon, asthma common
Diurnal variation: COPD uncommon, asthma common

41
Q

What is Cor Pulmonale?

A

Right sided HF
Result of pulmonary hypertension
Signs: Cyanosis, fluid retention, severe SOB, may have a diastolic murmur

42
Q

How is HAP defined?

A

Pneumonia developing 48hours after admission

Usually gram -ve bacilli, Staph Aureus

43
Q

What are the most common causes of CAP?

A

Strep Pneumoniae
H.Influenzae
Anaerobes (rare)

44
Q

How is CAP diagnosed?

A
CXR
Bloods: FBC, WCC, ESR, CRP
Pleural fluid aspiration
CURB 65: 
Confusion <8
Urea >7
RR >30
BP <90s/ <60d
>65
>3= severe
>2=Hospitalisation
45
Q

How is pneumonia treated?

A

Rest
Fluids
Abx: Amoxicillin/Clarithromycin 500mg PO TDS 1week
Severe: Co-Amoxiclav 1.2g & Clarithromycin 500mg 7-10days