Respiratory Failure Flashcards

(56 cards)

1
Q

What is adult respiratory distress syndrome

A

Fluid accumulation in alveoli due to increased permeability

Non cardiac pulmonary oedema

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2
Q

What are pulmonary causes of adult respiratory distress

A
Pneumonia
Direct lung injury 
Smoke inhalation
Vasculitis
Aspiration
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3
Q

What are other causes of RDS

A
Sepsis
Shock
Massive haemorrhage
Blood transfusion - within 6 hours usually known as TRALI
Trauma
Head injury = sympathetic = pulmonary hypertension
DIC
Pancreatitis
Liver failure
Bypass
Drugs / toxins
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4
Q

What are symptoms of RDS

A
Acute + severe
SOB
Tachycardia
Tachypnoea
Cyanosis
Bilateral crackles - fine
Low sats
Hyperaemia
Multi-organ failure
Signs of hypercapnia if rises
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5
Q

What are symptoms if on ventilatory

A

Rising ventilatory pressure

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6
Q

What is the criteria for diagnosing RDS

A

Within 1 week of trigger
Pulmonary oedema on CXR (not explained by collapse or effusion)
Non-cardiogenic cause
PaO2 <40kPa

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7
Q

How do you treat RDS

A
ITU
Oxygen
Negative fluid balance - diuretic / haemodialysis 
Ventilation - low TV 
CPAP but most need ventilation
Organ support 
Vasopressor to maintain CO 
Nutrition
Treat cause
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8
Q

What are complications of RDS

A

Scarring

Decreased lung function

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9
Q

What causes atelectasis (collapse)

A

Post-op
Obstructed airway - COPD / asthma
Basal alveolar collapse

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10
Q

When should you consider atelectasis post op

A

72 hours

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11
Q

What are the symptoms

A
SOB
Hypoxaemia
Resp difficulty 
Decreased expansion
Decreased breath sounds
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12
Q

How do you treat

A

Chest physio

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13
Q

What is type 1 respiratory failure

A

PaO2 <8

PaCo2 normal

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14
Q

What causes type 1 respiratory failure

A

V/Q mismatch
Hypoventilation
Abnormal diffusion
R-L shunt

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15
Q

What can cause a V/Q mismatch (poor perfusion due to barrier to gas exchange)

A
Pneumonia
Pulmonary oedema
PE
Asthma
Emphysema
Fibroids
RDS
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16
Q

What are the symptoms of type 1

A
Features of cause 
Features of hypoxia
Restless
SOB
Agitated
Confusion
Cyanosis
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17
Q

What happens in long standing type 1

A

Polycythaemia
Hypertension
Cor pulmonale

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18
Q

How do you Dx

A
FBC, U+E, CRP
ABG
CXR
Sputum and blood 
Spirometry
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19
Q

How do you treat type 1

A
Treat cause 
Oxygen 
Monitor O2 with ABG and increase if CO2 stable
Assisted ventilation if PaO2 <8
CPAP
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20
Q

Why do you want to control O2 delivery even in type 1

A

As want to be able to see if condition worsens and sats drop

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21
Q

Why is CPAP only indicated in type 1

A

Decreases ventilation as no pressure differenece
Can’t be used in type 2 which is due to decreased ventilation
Useful for pulmonary oedema as pushes fluid out

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22
Q

What does CPAP do

A

Stops lungs collapsing so increases O2 delivery

Can be delivered through high flow nasal cannula - 40l

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23
Q

What is O2 a good marker of

A

Diffusion i.e. in oedema / infection

24
Q

What is CO2 a good marker of

A

Poor ventilation

Very soluble so shouldn’t be affected by diffusion issues

25
What is type 2 resp failure
PaO2 <8 | PaCO2 >6
26
What causes type 2 respiratory failure
``` Alveolar hypoventilation with or without V/Q mismatch Ventilation issue Asthma COPD OSA Fibrosis Drugs CNS tumour Trauma Neuromuscular Thoracic wall disease ```
27
How does type 2 present
``` Hypercapnia Headache Peripheral vasodilation Tachycardia Bounding pulse Tremor Papilloedema Confusion Drowsy Coma ```
28
How do you treat type 2
``` Treat underlying cause Beware of hypoxic drive Controlled O2 Check ABG regularly Consider NIPPV if CO2 rising Bipap Intubation if this fails ECMO ```
29
What do you start at
24%
30
What do you aim sats to be
88-92%
31
Consequences
Acidosis
32
What is cor pulmonale
RHF due to pulmonary hypertension caused by respiratory disease
33
What causes cor pulmonale
Chronic lung disease - COPD = most common - Fibrosis - Severe asthma - Bronchiectasis - CF ``` Pulmonary vascular - PE - Vasculitis - PPH - ARDS - Sickle Neuromuscular - MS / MG Chest deformity / scoliosis Hypoventilation - OSA / adenoids Cerebrovascular ```
34
What are symptoms of cor pulmonate
``` Asymptomatic Dyspnoea = main Sx Fatigue Syncope CYanosis Tachycardia Raised JVP RV heave Loud P2 Pansystolic murmur - tricuspid regurgitation Hepatomegaly Peripheral oedema ```
35
How do you investigate
FBC - polycythaemia ABG CXR ECG - RAD / RVH
36
Wha will CXR show
Enlarged RA and RV | Prominent pulmonary arteries
37
How do you treat cor pulmonale
``` Treat cause Treat res failure Treat cardiac failure LTOT often needed Venesection if haemocrit >55% Heart and lung transplant in the young ```
38
What causes chronic ventilatory failure
``` Extreme OSA COPD Bronchiectasis Chest wall abnormality Resp muscle weakness e.g. MND Central hypoventilation ```
39
What are the symptoms of chronic ventilatory failure
``` SOB Orthopnoea Oedema 2 cor pulmonale Morning headache due to rise in CO2 Chest infection Disturbed sleep ```
40
What does blood gas show
Elevated CO2 | Decreased O2
41
How do you investigate chronic ventilatory failure
Lung function test Overnight oximetry CO2 monitoring Spirometry
42
Spirometry shows
Restrictive | Drop in vital capacity lying flat
43
How do you treat
Non-invasive ventilation Oxygen Tracheostomy if pH <7.25
44
Indications for non-invasive ventilation
COPD with pH 7.25-7.35 Type 2 res failure Cardiopulmonary oedema resistant to CPAP Weaning from tracheostomy
45
What excludes cardiac cause for ARDS
Normal capillary wedge pressure
46
When is ventilation indicated
pH <7.25
47
What is CPAP
Continuous +Ve airway pressure | Keeps airway expanded so air can move in and out
48
What are indications for CPAP
OSA CCF Acute pulmonary oedema
49
What is BiPAP
Bilevel +Ve airway pressure | Involves high or low pressures to correspond to ventilation
50
When is it used
Type 2 resp failure Usually due to COPD If pH <7.35 despite medical therapy
51
What does non-invasive ventilation mean?
* Non-invasive ventilation (NIV) delivers ventilatory support to improve respiratory failure via an inter- face that does not cross the larynx.
52
What is CPAP?
* CPAP applies a constant pressure throughout the respiratory cycle and works by splinting open and recruiting collapsed alveoli, thus reducing pulmonary circulatory shunting and improving lung compli- ance. * This improves oxygenation and reduces the work of breathing. * CPAP is often included under NIV, technically it does not provide ventilatory support as there is no assistance with inspiration.
53
Indications for CPAP [3]
* Worsening Type 1 respiratory failure by either bridging to or avoiding intubation. * Acute cardiogenic pulmonary oedema by improving lung compliance and oxygenation when drug treatment has been optimised. CPAP also assists in the translocation of interstitial fluid to the alveolar capillaries surrounding the alveoli, further improving gas exchange. * In the domiciliary setting, CPAP can be used as a treatment of obstructive sleep apnoea/ hypoapnoea syndrome (OSAHS) by splinting open the airways and improving oxygenation.
54
Indications for NIV [3]
* Acute exacerbation of COPD * Decompensated OSA * Respiratory failure secondary to neuromuscular weakness or chest wall deformity.
55
Patient monitoring on non-invasive ventilation or CPAP [2]
* For both CPAP and NIV, there should be continuous pulse oximetry and ECG monitoring for the first 2 hours, and regular RR, pulse, BP measurements and assessments of consciousness. * ABG should be taken as a minimum at 1, 4 and 12 hours after the initiation of NIV. This will guide changes in settings, escalation plans to intubation and ceilings of treatment.
56
Contraindications for non-invasive ventilation [7]
1. Impaired consciousness or confusion – the patient will not be able to trigger sufficient breaths and should be assessed for intubation immediately. 2. Life-threatening hypoxaemia. 3. Haemodynamic instability or arrest. NIV reduces preload so can lower blood pressure further, so patients should be considered for admission to ICU. 4. Facial surgery or burns. 5. Undrained pneumothorax: the positive pressure ventilation may convert a simple pneumothorax to a tension pneumothorax. 6. Vomiting. 7. Inability to protect airway, e.g. GCS < 8.