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Principles of Pharmacology > Respiratory Medications > Flashcards

Respiratory Medications Flashcards

1
Q

albuterol sulfate (Proventil)

A

a BRONCHODILATOR BETA AGONIST that binds and stimulates beta2 receptors, resulting in the relaxation of bronchial smooth muscle.

Onset - 5-15 minutes after inhalation
Duration - 3-4 hours after inhalation

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2
Q

albuterol sulfate (Proventil) Indications

A

Asthma, bronchitis with bronchospasm, and COPD.
Known or suspected hyperkalemia with EKG changes such as peaked T waves and QRS widening.

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3
Q

albuterol sulfate (Proventil) Contraindications

A

Sensitivity to albuterol or levalbuterol.
Severe tachycardia (relative)

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4
Q

albuterol sulfate (Proventil) Adverse Effects

A

Tachycardia, palpitations, and dysrhythmias.

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5
Q

albuterol sulfate (Proventil) Drug Interactions

A

Sympathomimetics may exacerbate adverse cardiovascular effects. Beta Blockers may antagonize albuterol.

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6
Q

albuterol sulfate (Proventil) Dosage and Administration

A

Single Neb:
One 2.5 mg/3 mL dose at a flow rate of 6-8 liters per minute was delivered over 5 to 15 minutes. May be repeated 2 times for a total of 3 administrations.

Continuous Neb:
3 2.5 mg/3 mL bullets for a total of 7.5 mg/9 mL at a flow rate of 6-8 liters per minute

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7
Q

albuterol sulfate (Proventil) Special Considerations

A

Use with caution in lactating patients, patients with cardiac dysrhythmias, suspected or known coronary disease, diabetes, hyperthyroidism, prostatic hypertrophy, or seizure disorders.

May precipitate angina and dysrhythmias.

Wheezing associated with anaphylaxis should first be treated with epinephrine IM.

Consider inline nebs for patients requiring endotracheal intubation or CPAP.

Pregnancy Class C.

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8
Q

epinephrine (Adrenalin)

A

An INOTROPIC ADRENERGIC catecholamine alpha, beta1 and beta2 adrenergic receptor agonist.

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9
Q

epinephrine (Adrenalin) Indications

A

Pulseless Arrest
Anaphylaxis
ASTHMA
Bradycardia with poor perfusion

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10
Q

epinephrine (Adrenalin) Adverse Reactions

A

Tachycardia and tachydysrhythmia
Hypertension
Anxiety
May precipitate angina pectoris

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11
Q

epinephrine (Adrenalin) Dosage for Asthma

A

Adult: 0.3 mg (0.3 mL of 1:1000) IM. May repeat dose 1 time.

Pediatric: 1 to 12 years old - 0.01 mg/kg (0.01 mL/kg of 1:1000) IM. May repeat dose one time after 5 minutes.

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12
Q

ipratropium bromide (Atrovent)

A

An ANTICHOLINERGIC BRONCHODILATOR that is chemically related to atropine, meaning it competes with acetylcholine at the site of the muscarinic receptor.

Onset - 5-15 minutes
Duration - 6-8 hours

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13
Q

ipratropium bromide (Atrovent) Indications

A

Bronchospasm

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14
Q

ipratropium bromide (Atrovent) Contraindications

A

Children under the age of 2
Soy or peanut allergy (MDI)

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15
Q

ipratropium bromide (Atrovent) Adverse Reactions

A

Palpitations
Tremors
Dry Mouth

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16
Q

ipratropium bromide (Atrovent) Dosage and Administration

A

Adult: 0.5 mg/2.5 mL along with albuterol in a nebulizer.

Pediatric: 2-12 years old - 0.5 mg/2.5 mL along with albuterol.
1-2 years - 0.25 mg with albuterol in a nebulizer.

Not indicated for repetitive dose or continuous neb use.

Pregnancy Class B.

17
Q

magnesium sulfate

A

An ELECTROLYTE that reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. It may act as a bronchodilator in acute bronchospasm due to asthma or other bronchospastic diseases.

18
Q

magnesium sulfate Indications

A

Severe bronchospasm unresponsive to continuous albuterol, ipratropium, and IM epinephrine.

19
Q

magnesium sulfate Precautions and Adverse Reactions

A

Bradycardia
Hypotension
Respiratory depression

20
Q

magnesium sulfate Dosage and Administration

A

2 g IV bolus

Not indicated for pediatrics

21
Q

methylprednisolone (Solu-Medrol)

A

A CORTICOSTEROID that suppresses acute and chronic inflammation and may alter the immune response. It potentiates vascular smooth muscle relaxation by beta-adrenergic agonists and may alter airway hyperactivity.

22
Q

methylprednisolone (Solu-Medrol) Indications

A

Anaphylaxis
Severe Asthma
COPD
Suspected Addisonian crisis (cardiovascular collapse in patient at risk for adrenal insufficiency)

23
Q

methylprednisolone (Solu-Medrol) Contraindications

A

Evidence of GI bleed

24
Q

methylprednisolone (Solu-Medrol) Adverse Reactions

A

Gastrointestinal bleeding
Hypertension
Hyperglycemia
(all typically results of long-term therapy)

25
Q

methylprednisolone (Solu-Medrol) Dosage and Administraton

A

125 mg IV bolus, slowly over 2 minutes

Pediatric: 2 mg/kg IV bolus, slowly over 2 minutes, max of 125 mg.

26
Q

methylprednisolone (Solu-Medrol) Special Considerations

A

Must be reconstituted and used immediately.
The effect is generally delayed for several hours.
Not considered a first-line drug. Be sure to attend to the patient’s primary treatment priority.
Do not delay transport to administer this drug. Administer during transport if there is time.

27
Q

nitroglycerin

A

An ANTIAGINAL that relaxes vascular smooth muscle, dilating peripheral arteries and veins causing pooling of venus blood and decreased venous return to the heart which decreases preload. Reduces left ventricular systolic wall tension which decreases afterload.

Onset - 1-3 minutes
Duration - 20-30 minutes

28
Q

nitroglycerin Indications

A

Pain or discomfort due to suspected acute coronary syndrome.
Pulmonary Edema due to congestive heart failure.

29
Q

nitroglycerin Contraindications

A

Suspected right ventricular ST-segment elevation MI (Inferior STEMI pattern plus ST elevation in right-sided precordial leads).
Hypotension, systolic less than 100
Recent use of erectile dysfunction medications

30
Q

nitorglycerin Adverse Reactions

A

Hypotension
Headache
Syncope

31
Q

nitroglycerin Dosage and Administration

A

Pulmonary Edema: 0.4 mg sublingually or spray every 5 minutes as needed, titrated to symptoms and blood pressure…or
1 inch of Nitropaste on the patient’s left anterior chest.

Pregnancy Class C.

32
Q

racepinephrine

A

An ADRENERGIC BRONCHODILATOR that stimulates both alpha and beta receptors, causing vasoconstriction, reduced mucosal edema, and bronchodilation.

Onset - 1-5 minutes
Duration - 1-3 hours

33
Q

racepinephrine Indications

A

Stridor at rest

34
Q

racepinephrine Side Effects

A

Tachycardia
Palpitations
Muscle Tremors

35
Q

racepinephrine Dosage and Administration

A

0.5 mL racemic epinephrine (acceptable dose for all ages) mixed in 3 mL saline, via nebulizer at 6-8 liters per minute over 15 minutes.

36
Q

racepinephrine Special Considerations

A

Heat and photosensitive.
Stable at room temperature until the expiration date set on the package.
Do not confuse the side effects with respiratory failure or imminent respiratory arrest.
If no racemic epinephrine is available, consider 5 mL of 1:1000 epinephrine via nebulizer at 6-8 liters per minute over 15 minutes.
.

Principles of Pharmacology (11 decks)

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