Resting Membrane Potential

Question 1

What is the purpose of equilibrium and membrane potential?

Answer 1

determine direction and magnitude of ion movement

Question 2

What is the equation for resting membrane potential?

Answer 2

I = G(Em-Ex)

(Em-Ex) > 0 outward current (-)
(Em-Ex) < 0 inward current (+)
Em = Ex current is 0

Question 3

What is the current-voltage relationship?

Answer 3

Current on y-axis and V on x-axis
- slope = conductance (G) — rise/run
- x-intercept = equilibrium potential (Ex)

Question 4

What is the Goldman Equation?

Answer 4

E = RT ln (P[Na] + P[K] + P[Cl]) out
F (P[Na] + P[K] + P[Cl]) in

• membrane potential depends on 3 ions permeabilities