Restrictive cardiomyopathy Flashcards
What is primary restrictive cardiomyopathy
When the heart develops restrictive cardiomyopathy by itself
What is secondary restrictive cardiomyopathy
From other condition such as hypertenstion/valve disease
What is restrictive cardiomyopathy
Stiffening of the myocardium
What effect does it have on stroke volume
Decreases stroke volume
Is it a systolic or diastolic heart failure
Diastolic
What are the main causes (LASHER)
Loffler syndrome, amyloidosis, sarcoidosis, haemochromotosis, endocardial fibroelastosis and radiation
What is amyloidosis
Deposits of amyloid proteins, in this case the deposits are in the heart
What is an amyloid protein
Misfolded protein and are therefore insoluble
What is familial amyloid cardiomyopathy
Heredity mutant TTR protein (normally transports thyroxine and retinol) deposits in the heart. More common in the black population
What is senile cardiac amyloidosis
Deposits of normal TTR in heart that normally occur in elderly
How does sarcoidosis cause restrictive cardiomyopathy
Granulomas (collection of immune cells) deposit into the heart wall
What is endocardial fibroelastosis
Fibrosis of endocardium abd subendocardium normally present in children. Often caused by infection and nutritional deficiencies.
What is loffler syndrome
Eosinophilic deposits in lungs. Loffler endo(myo)carditis is eosinophils in the heart wall
What is haemochromatosis
Iron overload and causes it by iron deposits in heart wall
How does radiation cause restrictive cardiomyopathy
Reactive oxygen species in heart wall that cause inflammation and fibrosis
