Restrictive Lung Diseases Flashcards
(26 cards)
Give 2 complications of RESTRICTIVE lung diseases
~ SECONDARY PULMONARY HPN —> Cor pulmonale
~ “HONEYCOMB LUNG”
3 common interstitial lung diseases
~ FIBROSING diseases
~ GRANULOMATOUS disease
~ SMOKING-related diseases
Histologic pattern of fibrosis: USUAL INTERSTITIAL PNEUMONIA (UIP)
Early lesion: (+) FIBSROBLASTIC FOCUS
Late lesion: (+) HONEYCOMB fibrosis
IDIOPATHIC PULMONARY FIBROSIS (IPF)
Cellular pattern:CHRONIC INFLAMMATION
Fibrosing pattern: INTERSTITIAL FIBROSIS
It has BETTER PROGNOSIS than IPF
(+) FEMALE NONSMOKERS 60 Y/O
NONSPECIFIC INTERSTITIAL PNEUMONIA
(+) MASSON BODIES
CRYPTOGENIC ORGANIZING PNEUMONIA
MASSON bodies — polypoid plugs of LOOSE ORGANIZING CONNECTIVE TISSUE within airways and alveoli
Most common indication for LUNG TRANSPLANTATION
IPF/ IDIOPATHIC PULMONARY FIBROSIS
Followed by COPD
NONNEOPLASTIC lung reaction to inhalation of MINERAL DUSTS encountered in the workplace
PNEUMOCONIOSIS
Common pathogenesis:
~ Particles phagocytized by pulmonary macrophages —> inflammation —> fibrosis
Carbon-laden macrophages
Coal MACULES (1-2 mm) — seen in SIMPLE COAL WORKERS’ PNEUMOCONIOSIS (CWP)
Carbon-laden MACROPHAGES + COLLAGEN fiber network
Coal NODULES
— seen in SIMPLE COAL WORKERS’ PNEUMOCONIOSIS (CWP)
MOST PREVALENT CHRONIC OCCUPATIONAL DISEASE
SILICOSIS
— Increased susceptibility to TB
— Increased risk of lung CA
CXR:
~ UPPER lobes
~ “EGGSHELL CALCIFICATIONS”: Lymph nodes
Morphology
~ (+) HARD COLLAGENOUS SCARS: central whorled collagen + rim of dust-laden macrophages
SILICOSIS
More PATHIGENIC form which causes Asbestos-related. Diseases
AMPHIBOLE form
Risk of BRONCHOGENIC CA > risk ofmesothelioma
CXR:
~ “IVORY WHITE” calcified supradiaphragmatic and pleural plaques
~ Recurrent pleural effusions
ASBESTOS-RELATED DISEASES
These are golden-brown, rods with translucent center consisting of ASBESTOS fibers coated with an iron-containing proteinaceous material
ASBESTOS bodies
These are other INORGANIC (Non-asbestos) particulates coated with similar IRON-protein complexes
FERRUGINOUS bodies
(+) Calcified pleural plaques, shipbuilding, ROOF insulation, tiling
ASBESTOSIS
(+) EGGSHELL calcification, stone blasting, sandblasting, quarrying
SILICOSIS
(+) Nodules along SEPTAL line, high-tech industries
BERYLLOSIS
(+) Hilar adenopathy, cotton
BYSSINOSIS
Diagnostic histologic finding:
NON-caseating GRANULOMAS with GIANT cells that may contain SCHAUMANN bodies and ASTEROID bodies
SARCOIDOSIS
What are the most common organs (2) involved in Sarcoidosis?
Lymph nodes and Lung
These are LAMINATED concretions composed of CALCIUM and PROTEINS
SCHAUMANN bodies
— seen in SARCOIDOSIS
These are STELLATE inclusions
ASTEROID bodies
— seen in SARCOIDOSIS
DUSTY BROWN PIGMENT-laden macrophages and may contain SURFACTANT-derived bodies due to phagocytosis pf necrotic TYPE 2 PNEUMOCYTES
SMOKERS’ MACROPHAGES
